Anatomy, Biochemistry and Physiology – University of Copenhagen

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Anatomy, Biochemistry and Physiology

Anatomy - Biochemistry- Physiology

Our research encompasses stem cells, embryology and cytogenetics, biomechanics and cartilage biology. Induced pluripotent stem cells (iPSC), embryonic stem cells and nerve stem cells from humans (http://www.stemmad.eu, www.brainstem.dk, www.neurostem.dk), dogs and pigs are studied in order e.g. to develop cellular models to study neurodegenerative diseases and other neurological diseases. As the most prominent action in this area, the Section is the home of the stem cell center BrainStem, supported by Innovation Fund Denmark.

Our projects in the field of embryology are aiming to contribute to precisely understand foetal development in the pig including epigenetics, which are foreseen to ultimately improve fertility. In addition, we do cytogenetic analysis of selected cases of congenital malformations, primarily of reproductive organs. We also pursue the application of in vitro fertilization in cattle as a potential future breeding technology where quantitative genetics can be used for the selection of the superior egg donors, embryos and recipients. Research in cartilage biology is primarily focused on the horse and at the moment we are investigating into the best possible cell source for cell therapy in orthopaedic disorders of horses.

Within biomechanics the main focus is on the importance of connective tissue layers and tendon durability in mobility disorders, while projects within cartilage are aiming at a deeper understanding of the inflammatory process and its importance in repair of joint cartilage.

The research within the general area of physiology include molecular physiology, cardiovascular physiology, lactational physiology, metabolic physiology and nutrition, physiology of skeletal muscles, paleo-biomedicine, metabolism of nutrients, need and use of nutrient and energy to foetal development, growth, reproduction and lactation, clinical nutrition.

The section has the following research groups:

Centres and consortia, in which members of the section participate: