Age-dependent differences in cytokine and antibody responses after experimental RSV infection in a bovine model
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Respiratory syncytial virus (RSV) causes severe respiratory disease in both infants and calves. As in humans, bovine RSV (BRSV) infections are most severe in the first 6 months of life. In this study, experimental infection with BRSV was performed in calves aged 1-5, 9-16 or 32-37 weeks. Compared to younger animals, older calves showed significantly less fever and lower TNFα levels and less virus-specific IFNγ release. In addition, blood from older animals had more mononuclear cells, more B cells and stronger BRSV-specific IgA and neutralising antibody responses to infection. A strong " inflammatory" but weak humoral antiviral response in very young animals suggests that enhanced inflammation contributes to disease during RSV infection during the early postnatal period.
Originalsprog | Engelsk |
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Tidsskrift | Vaccine |
Vol/bind | 23 |
Udgave nummer | 26 |
Sider (fra-til) | 3412-3423 |
Antal sider | 12 |
ISSN | 0264-410X |
DOI | |
Status | Udgivet - 16 maj 2005 |
Eksternt udgivet | Ja |
ID: 247400350