Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs

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Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs. / Mkupasi, Ernatus Martin; Sikasunge, Chummy Sikalizyo; Ngowi, Helena Aminiel; Leifsson, Páll S.; Johansen, Maria Vang.

I: Veterinary Parasitology, Bind 197, Nr. 1-2, 2013, s. 360-363.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Mkupasi, EM, Sikasunge, CS, Ngowi, HA, Leifsson, PS & Johansen, MV 2013, 'Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs', Veterinary Parasitology, bind 197, nr. 1-2, s. 360-363. https://doi.org/10.1016/j.vetpar.2013.05.004

APA

Mkupasi, E. M., Sikasunge, C. S., Ngowi, H. A., Leifsson, P. S., & Johansen, M. V. (2013). Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs. Veterinary Parasitology, 197(1-2), 360-363. https://doi.org/10.1016/j.vetpar.2013.05.004

Vancouver

Mkupasi EM, Sikasunge CS, Ngowi HA, Leifsson PS, Johansen MV. Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs. Veterinary Parasitology. 2013;197(1-2):360-363. https://doi.org/10.1016/j.vetpar.2013.05.004

Author

Mkupasi, Ernatus Martin ; Sikasunge, Chummy Sikalizyo ; Ngowi, Helena Aminiel ; Leifsson, Páll S. ; Johansen, Maria Vang. / Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs. I: Veterinary Parasitology. 2013 ; Bind 197, Nr. 1-2. s. 360-363.

Bibtex

@article{81363f8572e944fa86af1277308b9bc8,
title = "Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs",
abstract = "In order to further characterize the immune response around the viable or degenerating Taenia solium cysts in the pig brain, the involvement of cysteine protease in the immune evasion was assessed. Brain tissues from 30 adult pigs naturally infected with T. solium cysticercosis were subjected to histopathology using hematoxylin and eosin stain, and immunohistochemistry using caspase-3 antibodies. Histopathological evaluation revealed lesions of stage I which was characterized by presence of viable parasite surrounded with minimal to moderate inflammatory cells and stage III characterized by the presence of a disintegrating parasite surrounded with high inflammatory cells. The results of immunohistochemistry indicated caspase-3 positive cells interspaced between inflammatory infiltrate mainly in stage I lesions, indicating the presence of cysteine protease. This result confirms the earlier hypothesis that cysteine protease may play a role in inducing immune evasion through apoptosis around viable T. solium cysts.",
author = "Mkupasi, {Ernatus Martin} and Sikasunge, {Chummy Sikalizyo} and Ngowi, {Helena Aminiel} and Leifsson, {P{\'a}ll S.} and Johansen, {Maria Vang}",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
doi = "10.1016/j.vetpar.2013.05.004",
language = "English",
volume = "197",
pages = "360--363",
journal = "Veterinary Parasitology",
issn = "0304-4017",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Detection of cysteine protease in Taenia solium-induced brain granulomas in naturally infected pigs

AU - Mkupasi, Ernatus Martin

AU - Sikasunge, Chummy Sikalizyo

AU - Ngowi, Helena Aminiel

AU - Leifsson, Páll S.

AU - Johansen, Maria Vang

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013

Y1 - 2013

N2 - In order to further characterize the immune response around the viable or degenerating Taenia solium cysts in the pig brain, the involvement of cysteine protease in the immune evasion was assessed. Brain tissues from 30 adult pigs naturally infected with T. solium cysticercosis were subjected to histopathology using hematoxylin and eosin stain, and immunohistochemistry using caspase-3 antibodies. Histopathological evaluation revealed lesions of stage I which was characterized by presence of viable parasite surrounded with minimal to moderate inflammatory cells and stage III characterized by the presence of a disintegrating parasite surrounded with high inflammatory cells. The results of immunohistochemistry indicated caspase-3 positive cells interspaced between inflammatory infiltrate mainly in stage I lesions, indicating the presence of cysteine protease. This result confirms the earlier hypothesis that cysteine protease may play a role in inducing immune evasion through apoptosis around viable T. solium cysts.

AB - In order to further characterize the immune response around the viable or degenerating Taenia solium cysts in the pig brain, the involvement of cysteine protease in the immune evasion was assessed. Brain tissues from 30 adult pigs naturally infected with T. solium cysticercosis were subjected to histopathology using hematoxylin and eosin stain, and immunohistochemistry using caspase-3 antibodies. Histopathological evaluation revealed lesions of stage I which was characterized by presence of viable parasite surrounded with minimal to moderate inflammatory cells and stage III characterized by the presence of a disintegrating parasite surrounded with high inflammatory cells. The results of immunohistochemistry indicated caspase-3 positive cells interspaced between inflammatory infiltrate mainly in stage I lesions, indicating the presence of cysteine protease. This result confirms the earlier hypothesis that cysteine protease may play a role in inducing immune evasion through apoptosis around viable T. solium cysts.

U2 - 10.1016/j.vetpar.2013.05.004

DO - 10.1016/j.vetpar.2013.05.004

M3 - Journal article

C2 - 23726797

VL - 197

SP - 360

EP - 363

JO - Veterinary Parasitology

JF - Veterinary Parasitology

SN - 0304-4017

IS - 1-2

ER -

ID: 98162488