Efficacy and safety of anthelmintics tested against Taenia solium cysticercosis in pigs
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Standard
Efficacy and safety of anthelmintics tested against Taenia solium cysticercosis in pigs. / Mkupasi, Ernatus Martin; Sikasunge, Chummy Sikalizyo; Ngowi, Helena Aminiel; Johansen, Maria Vang.
I: P L o S Neglected Tropical Diseases (Online), Bind 7, Nr. 7, e2200, 2013.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Efficacy and safety of anthelmintics tested against Taenia solium cysticercosis in pigs
AU - Mkupasi, Ernatus Martin
AU - Sikasunge, Chummy Sikalizyo
AU - Ngowi, Helena Aminiel
AU - Johansen, Maria Vang
PY - 2013
Y1 - 2013
N2 - Porcine cysticercosis, an infection caused by Taenia solium metacestodes, is continuously being reported in low-income countries of Latin America, Asia, and sub-Saharan Africa. The disease was declared eradicable by the International Task Force for Diseases Eradication (ITFDE) in 1993, and it is listed among the 17 WHO Neglected Tropical Diseases and Neglected Zoonoses that are potentially eradicable. In view of that, WHO has proposed a step-wise approach to its elimination, including chemotherapy of infected pigs. Different drugs have been tested on porcine cysticercosis with varying efficacies. These include flubendazole, fenbendazole, albendazole, albendazole sulphoxide, oxfendazole, praziquantel, and nitazoxanide. This review summarises available information on the efficacies and adverse effects shown by these drugs in pigs. Oxfendazole has shown to be effective for the control of porcine cysticercosis; however, it needs to be integrated with other control approaches. There is a need for standardised guidelines for evaluating the efficacy of anthelmintics against porcine cysticercosis, and more efficacy studies are needed since the conclusions so far are based on a limited number of studies using few infected pigs.
AB - Porcine cysticercosis, an infection caused by Taenia solium metacestodes, is continuously being reported in low-income countries of Latin America, Asia, and sub-Saharan Africa. The disease was declared eradicable by the International Task Force for Diseases Eradication (ITFDE) in 1993, and it is listed among the 17 WHO Neglected Tropical Diseases and Neglected Zoonoses that are potentially eradicable. In view of that, WHO has proposed a step-wise approach to its elimination, including chemotherapy of infected pigs. Different drugs have been tested on porcine cysticercosis with varying efficacies. These include flubendazole, fenbendazole, albendazole, albendazole sulphoxide, oxfendazole, praziquantel, and nitazoxanide. This review summarises available information on the efficacies and adverse effects shown by these drugs in pigs. Oxfendazole has shown to be effective for the control of porcine cysticercosis; however, it needs to be integrated with other control approaches. There is a need for standardised guidelines for evaluating the efficacy of anthelmintics against porcine cysticercosis, and more efficacy studies are needed since the conclusions so far are based on a limited number of studies using few infected pigs.
U2 - 10.1371/journal.pntd.0002200
DO - 10.1371/journal.pntd.0002200
M3 - Journal article
C2 - 23936558
VL - 7
JO - P L o S Neglected Tropical Diseases (Online)
JF - P L o S Neglected Tropical Diseases (Online)
SN - 1935-2735
IS - 7
M1 - e2200
ER -
ID: 49458918