Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda

Institut for Veterinær- og Husdyrvidenskab

Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. / Namwanje, Harriet; Kabatereine, Narcis B.; Olsen, Annette.

I: Transactions of the Royal Society of Tropical Medicine and Hygiene, Bind 105, Nr. 10, 2011, s. 586-590.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Namwanje, H, Kabatereine, NB & Olsen, A 2011, 'Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda', Transactions of the Royal Society of Tropical Medicine and Hygiene, bind 105, nr. 10, s. 586-590. https://doi.org/10.1016/j.trstmh.2011.07.009

APA

Namwanje, H., Kabatereine, N. B., & Olsen, A. (2011). Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene, 105(10), 586-590. https://doi.org/10.1016/j.trstmh.2011.07.009

Vancouver

Namwanje H, Kabatereine NB, Olsen A. Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2011;105(10):586-590. https://doi.org/10.1016/j.trstmh.2011.07.009

Author

Namwanje, Harriet ; Kabatereine, Narcis B. ; Olsen, Annette. / Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda. I: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2011 ; Bind 105, Nr. 10. s. 586-590.

Bibtex

@article{c296d184a2fd4d589ae0ee68f0de087f,

title = "Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda",

abstract = "A randomised clinical trial was conducted in Kabale District, southwestern Uganda, to compare the efficacies of single and double doses of a combination of 400mg albendazole (ALB) and 500mg mebendazole (MBZ) with those of single and double doses of each drug given alone in the treatment of Trichuris trichiura. Infected pupils (n=611) were randomised to six treatment groups. Three groups received either a single dose of ALB, MBZ or the combination (ALB+MBZ). The other three groups received either a double dose of ALB (ALB/ALB), MBZ (MBZ/MBZ) or the combination (ALB+MBZ/ALB+MBZ). All double doses were given 8h apart. Children were followed-up weekly for 1 month. Cure rates were significantly higher using double doses compared with single doses (irrespective of drug; z=-4.02, P",

keywords = "Former LIFE faculty, Trichuris trichiura, Albendazole, Mebendazole, Combination drug therapy, Double dose, Uganda",

author = "Harriet Namwanje and Kabatereine, {Narcis B.} and Annette Olsen",

year = "2011",

doi = "10.1016/j.trstmh.2011.07.009",

language = "English",

volume = "105",

pages = "586--590",

journal = "Transactions of the Royal Society of Tropical Medicine and Hygiene",

issn = "0035-9203",

publisher = "Oxford University Press",

number = "10",

}

RIS

TY - JOUR

T1 - Efficacy of single and double doses of albendazole and mebendazole alone and in combination in the treatment of Trichuris trichiura in school-age children in Uganda

AU - Namwanje, Harriet

AU - Kabatereine, Narcis B.

AU - Olsen, Annette

PY - 2011

Y1 - 2011

N2 - A randomised clinical trial was conducted in Kabale District, southwestern Uganda, to compare the efficacies of single and double doses of a combination of 400mg albendazole (ALB) and 500mg mebendazole (MBZ) with those of single and double doses of each drug given alone in the treatment of Trichuris trichiura. Infected pupils (n=611) were randomised to six treatment groups. Three groups received either a single dose of ALB, MBZ or the combination (ALB+MBZ). The other three groups received either a double dose of ALB (ALB/ALB), MBZ (MBZ/MBZ) or the combination (ALB+MBZ/ALB+MBZ). All double doses were given 8h apart. Children were followed-up weekly for 1 month. Cure rates were significantly higher using double doses compared with single doses (irrespective of drug; z=-4.02, P

AB - A randomised clinical trial was conducted in Kabale District, southwestern Uganda, to compare the efficacies of single and double doses of a combination of 400mg albendazole (ALB) and 500mg mebendazole (MBZ) with those of single and double doses of each drug given alone in the treatment of Trichuris trichiura. Infected pupils (n=611) were randomised to six treatment groups. Three groups received either a single dose of ALB, MBZ or the combination (ALB+MBZ). The other three groups received either a double dose of ALB (ALB/ALB), MBZ (MBZ/MBZ) or the combination (ALB+MBZ/ALB+MBZ). All double doses were given 8h apart. Children were followed-up weekly for 1 month. Cure rates were significantly higher using double doses compared with single doses (irrespective of drug; z=-4.02, P

KW - Former LIFE faculty

KW - Trichuris trichiura

KW - Albendazole

KW - Mebendazole

KW - Combination drug therapy

KW - Double dose

KW - Uganda

U2 - 10.1016/j.trstmh.2011.07.009

DO - 10.1016/j.trstmh.2011.07.009

M3 - Journal article

C2 - 21885077

VL - 105

SP - 586

EP - 590

JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

JF - Transactions of the Royal Society of Tropical Medicine and Hygiene

SN - 0035-9203

IS - 10

ER -

ID: 35056163