Expression of matrix metalloproteinase-9 and -12 in porcine lung infections

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Expression of matrix metalloproteinase-9 and -12 in porcine lung infections. / Bruun, Camilla Vibeke Sichlau; Leifsson, Páll S.; Johansen, Louise Kruse; Jensen, Henrik Michael Elvang; Nielsen, J.; Fredholm, Merete.

I: Journal of Comparative Pathology, Bind 146, Nr. 2-3, 2012, s. 253-257.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Bruun, CVS, Leifsson, PS, Johansen, LK, Jensen, HME, Nielsen, J & Fredholm, M 2012, 'Expression of matrix metalloproteinase-9 and -12 in porcine lung infections', Journal of Comparative Pathology, bind 146, nr. 2-3, s. 253-257. https://doi.org/10.1016/j.jcpa.2011.05.005

APA

Bruun, C. V. S., Leifsson, P. S., Johansen, L. K., Jensen, H. M. E., Nielsen, J., & Fredholm, M. (2012). Expression of matrix metalloproteinase-9 and -12 in porcine lung infections. Journal of Comparative Pathology, 146(2-3), 253-257. https://doi.org/10.1016/j.jcpa.2011.05.005

Vancouver

Bruun CVS, Leifsson PS, Johansen LK, Jensen HME, Nielsen J, Fredholm M. Expression of matrix metalloproteinase-9 and -12 in porcine lung infections. Journal of Comparative Pathology. 2012;146(2-3):253-257. https://doi.org/10.1016/j.jcpa.2011.05.005

Author

Bruun, Camilla Vibeke Sichlau ; Leifsson, Páll S. ; Johansen, Louise Kruse ; Jensen, Henrik Michael Elvang ; Nielsen, J. ; Fredholm, Merete. / Expression of matrix metalloproteinase-9 and -12 in porcine lung infections. I: Journal of Comparative Pathology. 2012 ; Bind 146, Nr. 2-3. s. 253-257.

Bibtex

@article{714996bec4a948a7b1530857d3aa94a6,
title = "Expression of matrix metalloproteinase-9 and -12 in porcine lung infections",
abstract = "Matrix metalloproteinases (MMPs) play a variety of roles during organogenesis, in the immune response and during acute and chronic diseases as well as in tissue remodelling. During the last decade, the pig has become used increasingly as a model for human diseases; however, studies on the expression of porcine MMPs are limited. In the present study species-specific antibodies were produced to investigate the expression of MMP-9 and MMP-12 immunohistochemically in lungs from pigs infected with Actinobacillus pleuropneumoniae, Pasteurella multocida and Staphylococcus aureus. The immunolabelling of lung tissues (one infected and one control pig representing each infection) was evaluated for cellular distribution and intensity, which was scored semiquantitatively. When compared with healthy, non-infected controls, the expression of both MMP-9 and MMP-12 was higher in infected lungs. The highest expressions were seen in the alveolar epithelium (MMP-9) and alveolar macrophages (MMP-12). These results are in accordance with studies of human lungs.",
keywords = "Former LIFE faculty, immunohistochemistry, MMP-9, MMP-12, pig",
author = "Bruun, {Camilla Vibeke Sichlau} and Leifsson, {P{\'a}ll S.} and Johansen, {Louise Kruse} and Jensen, {Henrik Michael Elvang} and J. Nielsen and Merete Fredholm",
year = "2012",
doi = "10.1016/j.jcpa.2011.05.005",
language = "English",
volume = "146",
pages = "253--257",
journal = "Journal of Comparative Pathology",
issn = "0021-9975",
publisher = "Elsevier",
number = "2-3",

}

RIS

TY - JOUR

T1 - Expression of matrix metalloproteinase-9 and -12 in porcine lung infections

AU - Bruun, Camilla Vibeke Sichlau

AU - Leifsson, Páll S.

AU - Johansen, Louise Kruse

AU - Jensen, Henrik Michael Elvang

AU - Nielsen, J.

AU - Fredholm, Merete

PY - 2012

Y1 - 2012

N2 - Matrix metalloproteinases (MMPs) play a variety of roles during organogenesis, in the immune response and during acute and chronic diseases as well as in tissue remodelling. During the last decade, the pig has become used increasingly as a model for human diseases; however, studies on the expression of porcine MMPs are limited. In the present study species-specific antibodies were produced to investigate the expression of MMP-9 and MMP-12 immunohistochemically in lungs from pigs infected with Actinobacillus pleuropneumoniae, Pasteurella multocida and Staphylococcus aureus. The immunolabelling of lung tissues (one infected and one control pig representing each infection) was evaluated for cellular distribution and intensity, which was scored semiquantitatively. When compared with healthy, non-infected controls, the expression of both MMP-9 and MMP-12 was higher in infected lungs. The highest expressions were seen in the alveolar epithelium (MMP-9) and alveolar macrophages (MMP-12). These results are in accordance with studies of human lungs.

AB - Matrix metalloproteinases (MMPs) play a variety of roles during organogenesis, in the immune response and during acute and chronic diseases as well as in tissue remodelling. During the last decade, the pig has become used increasingly as a model for human diseases; however, studies on the expression of porcine MMPs are limited. In the present study species-specific antibodies were produced to investigate the expression of MMP-9 and MMP-12 immunohistochemically in lungs from pigs infected with Actinobacillus pleuropneumoniae, Pasteurella multocida and Staphylococcus aureus. The immunolabelling of lung tissues (one infected and one control pig representing each infection) was evaluated for cellular distribution and intensity, which was scored semiquantitatively. When compared with healthy, non-infected controls, the expression of both MMP-9 and MMP-12 was higher in infected lungs. The highest expressions were seen in the alveolar epithelium (MMP-9) and alveolar macrophages (MMP-12). These results are in accordance with studies of human lungs.

KW - Former LIFE faculty

KW - immunohistochemistry

KW - MMP-9

KW - MMP-12

KW - pig

U2 - 10.1016/j.jcpa.2011.05.005

DO - 10.1016/j.jcpa.2011.05.005

M3 - Journal article

VL - 146

SP - 253

EP - 257

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

SN - 0021-9975

IS - 2-3

ER -

ID: 35340858