High reinfection rate after preventive chemotherapy for fishborne zoonotic trematodes in Vietnam
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High reinfection rate after preventive chemotherapy for fishborne zoonotic trematodes in Vietnam. / Lier, Tore; Do, Dung Trung; Johansen, Maria Vang; Nguyen, Thi Hop; Dalsgaard, Anders; Asfeldt, Anne Mette.
I: P L o S Neglected Tropical Diseases (Online), Bind 8, Nr. 6, e2958, 2014.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - High reinfection rate after preventive chemotherapy for fishborne zoonotic trematodes in Vietnam
AU - Lier, Tore
AU - Do, Dung Trung
AU - Johansen, Maria Vang
AU - Nguyen, Thi Hop
AU - Dalsgaard, Anders
AU - Asfeldt, Anne Mette
PY - 2014
Y1 - 2014
N2 - BACKGROUND: The World Health Organization aims for complete morbidity control of fishborne zoonotic trematodes (FZT) in endemic areas by 2020. The main intervention tool for achieving this goal is regular use of preventive chemotherapy by offering praziquantel to those at risk in endemic areas. The purpose of this study was to investigate the effectiveness of preventive chemotherapy to control FZT in an endemic area in Northern Vietnam.METHODOLOGY AND PRINCIPLE FINDINGS: We followed a cohort of 396 people who fulfilled the criteria for receiving preventive chemotherapy. Stool samples were examined by Kato-Katz technique for the presence of trematode eggs before, and two, 16, 29 and 60 weeks after preventive chemotherapy. The prevalence of trematode eggs in stool was 40.2% before, 2.3% two weeks after and increased to a cumulative prevalence of 29.8% sixty weeks after preventive chemotherapy.CONCLUSIONS: The effectiveness of preventive chemotherapy as a main component in control of FZT is not well documented in most endemic areas. We found a high reinfection rate within the first year after preventive chemotherapy. Since these trematodes are zoonoses, preventive chemotherapy may not have sufficient impact alone on the transmission to have a lasting effect on the prevalence. Animal reservoirs and farm management practices must be targeted to achieve sustainable control of fishborne zoonotic trematode infections, hence control programs should consider a One Health approach.
AB - BACKGROUND: The World Health Organization aims for complete morbidity control of fishborne zoonotic trematodes (FZT) in endemic areas by 2020. The main intervention tool for achieving this goal is regular use of preventive chemotherapy by offering praziquantel to those at risk in endemic areas. The purpose of this study was to investigate the effectiveness of preventive chemotherapy to control FZT in an endemic area in Northern Vietnam.METHODOLOGY AND PRINCIPLE FINDINGS: We followed a cohort of 396 people who fulfilled the criteria for receiving preventive chemotherapy. Stool samples were examined by Kato-Katz technique for the presence of trematode eggs before, and two, 16, 29 and 60 weeks after preventive chemotherapy. The prevalence of trematode eggs in stool was 40.2% before, 2.3% two weeks after and increased to a cumulative prevalence of 29.8% sixty weeks after preventive chemotherapy.CONCLUSIONS: The effectiveness of preventive chemotherapy as a main component in control of FZT is not well documented in most endemic areas. We found a high reinfection rate within the first year after preventive chemotherapy. Since these trematodes are zoonoses, preventive chemotherapy may not have sufficient impact alone on the transmission to have a lasting effect on the prevalence. Animal reservoirs and farm management practices must be targeted to achieve sustainable control of fishborne zoonotic trematode infections, hence control programs should consider a One Health approach.
U2 - 10.1371/journal.pntd.0002958
DO - 10.1371/journal.pntd.0002958
M3 - Journal article
C2 - 24945411
VL - 8
JO - P L o S Neglected Tropical Diseases (Online)
JF - P L o S Neglected Tropical Diseases (Online)
SN - 1935-2735
IS - 6
M1 - e2958
ER -
ID: 123673979