Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk

Publikation: Bidrag til bog/antologi/rapportKonferenceabstrakt i proceedingsForskning

Standard

Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk. / Okura, Hisako; Nielsen, Søren Saxmose; Toft, Nils.

Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics. Wageningen Academic Publishers, 2012. s. 132.

Publikation: Bidrag til bog/antologi/rapportKonferenceabstrakt i proceedingsForskning

Harvard

Okura, H, Nielsen, SS & Toft, N 2012, Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk. i Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics. Wageningen Academic Publishers, s. 132, 13th International Symposium on Veterinary Epidemiology and Economics, Maastricht, Holland, 20/08/2012. <http://orbit.dtu.dk/fedora/objects/orbit:123085/datastreams/file_85fd15d8-5f16-4fc5-a125-caddfb9009a9/content>

APA

Okura, H., Nielsen, S. S., & Toft, N. (2012). Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk. I Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics (s. 132). Wageningen Academic Publishers. http://orbit.dtu.dk/fedora/objects/orbit:123085/datastreams/file_85fd15d8-5f16-4fc5-a125-caddfb9009a9/content

Vancouver

Okura H, Nielsen SS, Toft N. Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk. I Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics. Wageningen Academic Publishers. 2012. s. 132

Author

Okura, Hisako ; Nielsen, Søren Saxmose ; Toft, Nils. / Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk. Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics. Wageningen Academic Publishers, 2012. s. 132

Bibtex

@inbook{968fd519580441879032a519562996c5,
title = "Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk",
abstract = "Mycobacterium avium subsp. paratuberculosis (MAP) in milk of bovine origin is suspected of being implicated Crohn{\textquoteright}s disease in humans. Pasteurization is considered to reduce the concentration of MAP by at least 4 to 5 log10. This study aimed at estimating the level of MAP in milk at farm level and simulating the effect of different control options at different infection prevalences. The concentration of MAP in milk was estimated using a hierarchical simulation model representing individual cows in a herd while taking both direct and indirect contamination with MAP into account. Parameters included true within-herd infection prevalences with cows in different infection stages, which were used to estimate prevalences of milk and fecal shedders, and subsequently MAP concentrations in milk and feces. Cows in different infection stages were considered with different risks of excreting MAP testing positive. Furthermore, direct MAP contamination of milk was related to infection stages while indirect contamination was associated to within-herd prevalence and distribution of infection stages. Control options implemented included discarding of milk based on diagnostic test results. Median MAP load in farm bulk tank milk at within-herd infection prevalences from 7.5 to 60% were estimated to 0.74-6.81 cfu/ml, of which the contribution of direct contamination was less than 1%. Maximum concentration at the prevalence of 60% could be 1186 cfu/ml caused by shedding of high amounts of MAP in feces from super-shedders. At the prevalence of 15%, discarding milk from test positive cows would result in discarding 11% of milk and reduce the MAP level by 80%. The model was relatively simple yet capable of capturing true infection status and associated contributions from milk and feces. Further knowledge on distribution of fecal excretion from infected cows is required because very few {\textquoteleft}super-shedders{\textquoteright} might play a major role. The results can be used for a formal risk assessment including effects such as pasteurization. ",
author = "Hisako Okura and Nielsen, {S{\o}ren Saxmose} and Nils Toft",
year = "2012",
language = "English",
pages = "132",
booktitle = "Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics",
publisher = "Wageningen Academic Publishers",
address = "Netherlands",
note = "13th International Symposium on Veterinary Epidemiology and Economics, ISVEE ; Conference date: 20-08-2012 Through 24-08-2012",

}

RIS

TY - ABST

T1 - Modeling of Mycobacterium avium subsp. paratuberculosis in farm bulk tank milk

AU - Okura, Hisako

AU - Nielsen, Søren Saxmose

AU - Toft, Nils

N1 - Conference code: 13

PY - 2012

Y1 - 2012

N2 - Mycobacterium avium subsp. paratuberculosis (MAP) in milk of bovine origin is suspected of being implicated Crohn’s disease in humans. Pasteurization is considered to reduce the concentration of MAP by at least 4 to 5 log10. This study aimed at estimating the level of MAP in milk at farm level and simulating the effect of different control options at different infection prevalences. The concentration of MAP in milk was estimated using a hierarchical simulation model representing individual cows in a herd while taking both direct and indirect contamination with MAP into account. Parameters included true within-herd infection prevalences with cows in different infection stages, which were used to estimate prevalences of milk and fecal shedders, and subsequently MAP concentrations in milk and feces. Cows in different infection stages were considered with different risks of excreting MAP testing positive. Furthermore, direct MAP contamination of milk was related to infection stages while indirect contamination was associated to within-herd prevalence and distribution of infection stages. Control options implemented included discarding of milk based on diagnostic test results. Median MAP load in farm bulk tank milk at within-herd infection prevalences from 7.5 to 60% were estimated to 0.74-6.81 cfu/ml, of which the contribution of direct contamination was less than 1%. Maximum concentration at the prevalence of 60% could be 1186 cfu/ml caused by shedding of high amounts of MAP in feces from super-shedders. At the prevalence of 15%, discarding milk from test positive cows would result in discarding 11% of milk and reduce the MAP level by 80%. The model was relatively simple yet capable of capturing true infection status and associated contributions from milk and feces. Further knowledge on distribution of fecal excretion from infected cows is required because very few ‘super-shedders’ might play a major role. The results can be used for a formal risk assessment including effects such as pasteurization.

AB - Mycobacterium avium subsp. paratuberculosis (MAP) in milk of bovine origin is suspected of being implicated Crohn’s disease in humans. Pasteurization is considered to reduce the concentration of MAP by at least 4 to 5 log10. This study aimed at estimating the level of MAP in milk at farm level and simulating the effect of different control options at different infection prevalences. The concentration of MAP in milk was estimated using a hierarchical simulation model representing individual cows in a herd while taking both direct and indirect contamination with MAP into account. Parameters included true within-herd infection prevalences with cows in different infection stages, which were used to estimate prevalences of milk and fecal shedders, and subsequently MAP concentrations in milk and feces. Cows in different infection stages were considered with different risks of excreting MAP testing positive. Furthermore, direct MAP contamination of milk was related to infection stages while indirect contamination was associated to within-herd prevalence and distribution of infection stages. Control options implemented included discarding of milk based on diagnostic test results. Median MAP load in farm bulk tank milk at within-herd infection prevalences from 7.5 to 60% were estimated to 0.74-6.81 cfu/ml, of which the contribution of direct contamination was less than 1%. Maximum concentration at the prevalence of 60% could be 1186 cfu/ml caused by shedding of high amounts of MAP in feces from super-shedders. At the prevalence of 15%, discarding milk from test positive cows would result in discarding 11% of milk and reduce the MAP level by 80%. The model was relatively simple yet capable of capturing true infection status and associated contributions from milk and feces. Further knowledge on distribution of fecal excretion from infected cows is required because very few ‘super-shedders’ might play a major role. The results can be used for a formal risk assessment including effects such as pasteurization.

M3 - Conference abstract in proceedings

SP - 132

BT - Book of Abstracts of the 13th International Symposium on Veterinary Epidemiology and Economics

PB - Wageningen Academic Publishers

T2 - 13th International Symposium on Veterinary Epidemiology and Economics

Y2 - 20 August 2012 through 24 August 2012

ER -

ID: 40503955