TY - JOUR

T1 - Selected pharmacokinetic parameters for cefovecin in hens and green iguanas

AU - Thuesen, Line Risager

AU - Bertelsen, Mads Frost

AU - Brimer, Leon

AU - Skaanild, Mette Tingleff

PY - 2009

Y1 - 2009

N2 - The third generation cephalosporin cefovecin has been shown to have an exceptionally long elimination half-life in dogs and cats, making it suitable for antibacterial treatment with a 14-day dosing interval in these species. Pharmacokinetic parameters for cefovecin were investigated in juvenile hens and green iguanas, following subcutaneous injections with 10 mg cefovecin / kg bodyweight. Preliminary studies in eight additional species of birds and reptiles were performed and results were compared with the parameters found in hens and green iguanas. The kinetics were characterized by rapid absorption with peak plasma concentration of 6 ± 2 lg / mL in hens and 35 ± 12 lg / mL in green iguanas. The mean plasma half-life for cefovecin was 0.9 ± 0.3 h for hens and 3.9 h in green iguanas. Volume of distribution was 1.6 ± 0.5 L / kg for hens and 0.3 L / kg for green iguanas and clearance was 1252 ± 185 mLÆh/ kg for hens and 53 mLÆh/ kg for green iguanas. Results from preliminary studies did not differ notably from those seen in hens and green iguanas. Cefovecin is not suitable for the treatment of bacterial infections with a 14-day dosing interval in hens or green iguanas and seems not to be in a number of other bird and retile species either.

AB - The third generation cephalosporin cefovecin has been shown to have an exceptionally long elimination half-life in dogs and cats, making it suitable for antibacterial treatment with a 14-day dosing interval in these species. Pharmacokinetic parameters for cefovecin were investigated in juvenile hens and green iguanas, following subcutaneous injections with 10 mg cefovecin / kg bodyweight. Preliminary studies in eight additional species of birds and reptiles were performed and results were compared with the parameters found in hens and green iguanas. The kinetics were characterized by rapid absorption with peak plasma concentration of 6 ± 2 lg / mL in hens and 35 ± 12 lg / mL in green iguanas. The mean plasma half-life for cefovecin was 0.9 ± 0.3 h for hens and 3.9 h in green iguanas. Volume of distribution was 1.6 ± 0.5 L / kg for hens and 0.3 L / kg for green iguanas and clearance was 1252 ± 185 mLÆh/ kg for hens and 53 mLÆh/ kg for green iguanas. Results from preliminary studies did not differ notably from those seen in hens and green iguanas. Cefovecin is not suitable for the treatment of bacterial infections with a 14-day dosing interval in hens or green iguanas and seems not to be in a number of other bird and retile species either.

KW - Former LIFE faculty

U2 - 10.1111/j.1365-2885.2009.01083.x

DO - 10.1111/j.1365-2885.2009.01083.x

M3 - Journal article

C2 - 20444017

VL - 32

SP - 613

EP - 617

JO - Journal of Veterinary Pharmacology and Therapeutics

JF - Journal of Veterinary Pharmacology and Therapeutics

SN - 0140-7783

IS - 6

ER -