Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses. / Carstensen, Helena; Hesselkilde, Eva Z.; Fenner, Merle; Loft-Andersen, Ameli V.; Flethøj, Mette; Kanters, Jørgen K.; Sattler, Stefan M.; Tfelt-Hansen, Jacob; Pehrson, Steen; Jespersen, Thomas; Buhl, Rikke.

I: Journal of Veterinary Internal Medicine, Bind 32, Nr. 5, 2018, s. 1708-1717.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Carstensen, H, Hesselkilde, EZ, Fenner, M, Loft-Andersen, AV, Flethøj, M, Kanters, JK, Sattler, SM, Tfelt-Hansen, J, Pehrson, S, Jespersen, T & Buhl, R 2018, 'Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses', Journal of Veterinary Internal Medicine, bind 32, nr. 5, s. 1708-1717. https://doi.org/10.1111/jvim.15287

APA

Carstensen, H., Hesselkilde, E. Z., Fenner, M., Loft-Andersen, A. V., Flethøj, M., Kanters, J. K., Sattler, S. M., Tfelt-Hansen, J., Pehrson, S., Jespersen, T., & Buhl, R. (2018). Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses. Journal of Veterinary Internal Medicine, 32(5), 1708-1717. https://doi.org/10.1111/jvim.15287

Vancouver

Carstensen H, Hesselkilde EZ, Fenner M, Loft-Andersen AV, Flethøj M, Kanters JK o.a. Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses. Journal of Veterinary Internal Medicine. 2018;32(5):1708-1717. https://doi.org/10.1111/jvim.15287

Author

Carstensen, Helena ; Hesselkilde, Eva Z. ; Fenner, Merle ; Loft-Andersen, Ameli V. ; Flethøj, Mette ; Kanters, Jørgen K. ; Sattler, Stefan M. ; Tfelt-Hansen, Jacob ; Pehrson, Steen ; Jespersen, Thomas ; Buhl, Rikke. / Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses. I: Journal of Veterinary Internal Medicine. 2018 ; Bind 32, Nr. 5. s. 1708-1717.

Bibtex

@article{8b634a0155864f2c9c7c99199168ad41,
title = "Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses",
abstract = "BACKGROUND: Pharmacological treatment of atrial fibrillation (AF) in horses can be challenging because of low efficacy and adverse effects. Flecainide has been tested with variable efficacy.OBJECTIVE: To test whether the efficacy of flecainide is dependent on AF duration.ANIMALS: Nine Standardbred mares.METHODS: Factorial study design. All horses were instrumented with a pacemaker and assigned to a control or an AF group. On day 0, all horses were in sinus rhythm and received 2 mg/kg flecainide IV. Atrial fibrillation subsequently was induced in the AF group by pacemaker stimulation. On days 3, 9, 27, and 55, flecainide was administered to all horses, regardless of heart rhythm.RESULTS: All horses in AF cardioverted to sinus rhythm on days 3 and 9. On day 27, 5/6 horses cardioverted, whereas only 2/6 cardioverted on day 55. The time from the start of flecainide infusion to cardioversion (range, 3-185 min, log transformed) showed linear correlation with the cumulative duration of AF (r 2  = .80, P < .0001). Flecainide induced abnormal QRS complexes in 4/6 AF horses and 1/3 controls. A positive correlation was found between heart rate before flecainide infusion and number of abnormal QRS complexes (0.14, P < .05). One horse suffered from cardiac arrest and died after flecainide infusion. CONCLUSIONS AND CLINICAL IMPORTANCE: Flecainide is effective for cardioversion of short-term induced AF, but the effect decreases with AF duration. Controlling heart rate may minimize adverse effects caused by flecainide, but the drug should be used with great caution.",
keywords = "arrhythmia, atria, cardioversion, electrocardiography, heart, wide QRS tachycardia",
author = "Helena Carstensen and Hesselkilde, {Eva Z.} and Merle Fenner and Loft-Andersen, {Ameli V.} and Mette Fleth{\o}j and Kanters, {J{\o}rgen K.} and Sattler, {Stefan M.} and Jacob Tfelt-Hansen and Steen Pehrson and Thomas Jespersen and Rikke Buhl",
year = "2018",
doi = "10.1111/jvim.15287",
language = "English",
volume = "32",
pages = "1708--1717",
journal = "Journal of Veterinary Internal Medicine",
issn = "0891-6640",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Time-dependent antiarrhythmic effects of flecainide on induced atrial fibrillation in horses

AU - Carstensen, Helena

AU - Hesselkilde, Eva Z.

AU - Fenner, Merle

AU - Loft-Andersen, Ameli V.

AU - Flethøj, Mette

AU - Kanters, Jørgen K.

AU - Sattler, Stefan M.

AU - Tfelt-Hansen, Jacob

AU - Pehrson, Steen

AU - Jespersen, Thomas

AU - Buhl, Rikke

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Pharmacological treatment of atrial fibrillation (AF) in horses can be challenging because of low efficacy and adverse effects. Flecainide has been tested with variable efficacy.OBJECTIVE: To test whether the efficacy of flecainide is dependent on AF duration.ANIMALS: Nine Standardbred mares.METHODS: Factorial study design. All horses were instrumented with a pacemaker and assigned to a control or an AF group. On day 0, all horses were in sinus rhythm and received 2 mg/kg flecainide IV. Atrial fibrillation subsequently was induced in the AF group by pacemaker stimulation. On days 3, 9, 27, and 55, flecainide was administered to all horses, regardless of heart rhythm.RESULTS: All horses in AF cardioverted to sinus rhythm on days 3 and 9. On day 27, 5/6 horses cardioverted, whereas only 2/6 cardioverted on day 55. The time from the start of flecainide infusion to cardioversion (range, 3-185 min, log transformed) showed linear correlation with the cumulative duration of AF (r 2  = .80, P < .0001). Flecainide induced abnormal QRS complexes in 4/6 AF horses and 1/3 controls. A positive correlation was found between heart rate before flecainide infusion and number of abnormal QRS complexes (0.14, P < .05). One horse suffered from cardiac arrest and died after flecainide infusion. CONCLUSIONS AND CLINICAL IMPORTANCE: Flecainide is effective for cardioversion of short-term induced AF, but the effect decreases with AF duration. Controlling heart rate may minimize adverse effects caused by flecainide, but the drug should be used with great caution.

AB - BACKGROUND: Pharmacological treatment of atrial fibrillation (AF) in horses can be challenging because of low efficacy and adverse effects. Flecainide has been tested with variable efficacy.OBJECTIVE: To test whether the efficacy of flecainide is dependent on AF duration.ANIMALS: Nine Standardbred mares.METHODS: Factorial study design. All horses were instrumented with a pacemaker and assigned to a control or an AF group. On day 0, all horses were in sinus rhythm and received 2 mg/kg flecainide IV. Atrial fibrillation subsequently was induced in the AF group by pacemaker stimulation. On days 3, 9, 27, and 55, flecainide was administered to all horses, regardless of heart rhythm.RESULTS: All horses in AF cardioverted to sinus rhythm on days 3 and 9. On day 27, 5/6 horses cardioverted, whereas only 2/6 cardioverted on day 55. The time from the start of flecainide infusion to cardioversion (range, 3-185 min, log transformed) showed linear correlation with the cumulative duration of AF (r 2  = .80, P < .0001). Flecainide induced abnormal QRS complexes in 4/6 AF horses and 1/3 controls. A positive correlation was found between heart rate before flecainide infusion and number of abnormal QRS complexes (0.14, P < .05). One horse suffered from cardiac arrest and died after flecainide infusion. CONCLUSIONS AND CLINICAL IMPORTANCE: Flecainide is effective for cardioversion of short-term induced AF, but the effect decreases with AF duration. Controlling heart rate may minimize adverse effects caused by flecainide, but the drug should be used with great caution.

KW - arrhythmia

KW - atria

KW - cardioversion

KW - electrocardiography

KW - heart

KW - wide QRS tachycardia

U2 - 10.1111/jvim.15287

DO - 10.1111/jvim.15287

M3 - Journal article

C2 - 30133839

AN - SCOPUS:85052431811

VL - 32

SP - 1708

EP - 1717

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 5

ER -

ID: 203562916