Ernst Stefan Seemann

Ernst Stefan Seemann

Associate Professor

Member of:


    1. 2023
    2. Published

      Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3

      Haukedal, H., Syshøj Lorenzen, S., Westi, Emil Winther, Corsi, G., Gadekar, V. P., McQuade, A., Davtyan, H., Doncheva, Nadezhda Tsankova, Schmid, B., Chandrasekaran, Abinaya, Seemann, Ernst Stefan, Cirera, Susanna, Blurton-Jones, M., Meyer, M., Gorodkin, Jan, Aldana, Blanca & Freude, Kristine, 2023, In: Brain, Behavior, and Immunity. 113, p. 353-373

      Research output: Contribution to journalJournal articlepeer-review

    3. Published

      CRISPRi screen for enhancing heterologous alpha-amylase yield in Bacillus subtilis

      Geissler, Adrian Sven, Fehler, A. O., Poulsen, L. D., Gonzalez-Tortuero, E., Kallehauge, T. B., Alkan, F., Anthon, Christian, Seemann, Ernst Stefan, Rasmussen, M. D., Breuener, A., Hjort, C., Vinther, Jeppe & Gorodkin, Jan, 2023, In: Journal of Industrial Microbiology and Biotechnology. 50, 1, 16 p., kuac028.

      Research output: Contribution to journalJournal articlepeer-review

    4. Published

      Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi

      Cavazza, A., Hendel, A., Bak, R. O., Rio, P., Güell, M., Lainšček, D., Arechavala-Gomeza, V., Peng, L., Hapil, F. Z., Harvey, J., Ortega, F. G., Gonzalez-Martinez, C., Lederer, C. W., Mikkelsen, K., Gasiunas, G., Kalter, N., Gonçalves, M. A. F. V., Petersen, J., Garanto, A., Montoliu, L. & 20 others, Maresca, M., Seemann, Ernst Stefan, Gorodkin, Jan, Mazini, L., Sanchez, R., Rodriguez-Madoz, J. R., Maldonado-Pérez, N., Laura, T., Schmueck-Henneresse, M., Maccalli, C., Grünewald, J., Carmona, G., Kachamakova-Trojanowska, N., Miccio, A., Martin, F., Turchiano, G., Cathomen, T., Luo, Y., Tsai, S. Q. & Benabdellah, K., 2023, In: Molecular Therapy Nucleic Acids. 34, 14 p., 102066.

      Research output: Contribution to journalReviewpeer-review

    5. Published

      RNA-Seq Study on the Longissimus thoracis Muscle of Italian Large White Pigs Fed Extruded Linseed with or without Antioxidants and Polyphenols

      Vegni, J., Sun, Y., Seemann, Ernst Stefan, Zappaterra, M., Davoli, R., Dall’Olio, S., Gorodkin, Jan & Zambonelli, P., 2023, In: Animals. 13, 7, 1187.

      Research output: Contribution to journalJournal articlepeer-review

    6. Published

      The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression

      Corsi, G. I., Gadekar, V. P., Haukedal, H., Doncheva, Nadezhda Tsankova, Anthon, Christian, Ambardar, S., Palakodeti, D., Hyttel, P., Freude, Kristine, Seemann, Ernst Stefan & Gorodkin, Jan, 2023, In: Neurobiology of Disease. 178, 17 p., 105980.

      Research output: Contribution to journalJournal articlepeer-review

    7. 2022
    8. Published
    9. Published

      CRISPRroots: On-and off-target assessment of RNA-seq data in CRISPR-Cas9 edited cells

      Corsi, G. I., Gadekar, V. P., Gorodkin, Jan & Seemann, Ernst Stefan, 2022, In: Nucleic Acids Research. 50, 4, 12 p., E20.

      Research output: Contribution to journalJournal articlepeer-review

    10. Published

      Does rapid sequence divergence preclude RNA structure conservation in vertebrates?

      Seemann, Ernst Stefan, Mirza, A. H., Bang-Berthelsen, C. H., Garde, C., Christensen-Dalsgaard, M., Workman, C. T., Pociot, Flemming, Tommerup, Niels, Gorodkin, Jan & Ruzzo, W. L., 2022, In: Nucleic Acids Research. 50, 5, p. 2452-2463 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    11. Published

      Flagella disruption in Bacillus subtilis increases amylase production yield

      Fehler, A. O., Kallehauge, T. B., Geissler, Adrian Sven, González-Tortuero, E., Seemann, Ernst Stefan, Gorodkin, Jan & Vinther, Jeppe, 2022, In: Microbial Cell Factories. 21, 11 p., 131.

      Research output: Contribution to journalJournal articlepeer-review

    12. Published

      Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

      Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, Hall, Vanessa Jane, 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.

      Research output: Contribution to journalJournal articlepeer-review

    13. Published

      The Bacillaceae-1 RNA motif comprises two distinct classes

      González-Tortuero, E., Anthon, Christian, Havgaard, Jakob Hull, Geissler, Adrian Sven, Breüner, A., Hjort, C., Gorodkin, Jan & Seemann, Ernst Stefan, 2022, In: Gene. 841, 146756.

      Research output: Contribution to journalJournal articlepeer-review

    14. Published

      The impact of PrsA over-expression on the Bacillus subtilis transcriptome during fed-batch fermentation of alpha-amylase production

      Geissler, Adrian Sven, Poulsen, L. D., Doncheva, Nadezhda Tsankova, Anthon, Christian, Seemann, Ernst Stefan, González-Tortuero, E., Breüner, A., Jensen, Lars Juhl, Hjort, C., Vinther, Jeppe & Gorodkin, Jan, 2022, In: Frontiers in Microbiology. 13, 17 p., 909493.

      Research output: Contribution to journalJournal articlepeer-review

    15. 2021
    16. Published

      Bsgatlas: A unified bacillus subtilis genome and transcriptome annotation atlas with enhanced information access

      Geissler, Adrian Sven, Anthon, Christian, Alkan, F., González-Tortuero, E., Poulsen, L. D., Kallehauge, T. B., Breüner, A., Seemann, Ernst Stefan, Vinther, Jeppe & Gorodkin, Jan, 2021, In: Microbial Genomics. 7, 2, 17 p., 000524.

      Research output: Contribution to journalJournal articlepeer-review

    17. Published

      Development of the entorhinal cortex occurs via parallel lamination during neurogenesis

      Liu, Y., Bergmann, T., Mori, Yuki, Peralvo Vidal, Juan Miguel, Pihl, M., Vasistha, Navneet A, Thomsen, Preben Dybdahl, Seemann, Ernst Stefan, Gorodkin, Jan, Hyttel, P., Khodosevich, Konstantin, Witter, M. P. & Hall, Vanessa Jane, 2021, In: Frontiers in Neuroanatomy. 15, 19 p., 663667.

      Research output: Contribution to journalJournal articlepeer-review

    18. Published
    19. Published

      RNAcentral 2021: Secondary structure integration, improved sequence search and new member databases

      Sweeney, B. A., Petrov, A. I., Ribas, C. E., Finn, R. D., Bateman, A., Szymanski, M., Karlowski, W. M., Seemann, S. E., Gorodkin, J., Cannone, J. J., Gutell, R. R., Kay, S., Marygold, S., Dos Santos, G., Frankish, A., Mudge, J. M., Barshir, R., Fishilevich, S., Chan, P. P., Lowe, T. M. & 26 others, Seal, R., Bruford, E., Panni, S., Porras, P., Karagkouni, D., Hatzigeorgiou, A. G., Ma, L., Zhang, Z., Volders, P. J., Mestdagh, P., Griffiths-Jones, S., Fromm, B., Peterson, K. J., Kalvari, I., Nawrocki, E. P., Petrov, A. S., Weng, S., Bouchard-Bourelle, P., Scott, M., Lui, L. M., Hoksza, D., Lovering, R. C., Kramarz, B., Mani, P., Ramachandran, S. & Weinberg, Z., 2021, In: Nucleic Acids Research. 49, D1, p. D212-D220

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      The canine activated platelet secretome (CAPS): A translational model of thrombin-evoked platelet activation response

      Cremer, Signe Emilie, Catalfamo, J. L., Goggs, R., Seemann, Ernst Stefan, Kristensen, Annemarie T., Szklanna, P. B., Maguire, P. B. & Brooks, M. B., 2021, In: Research and Practice in Thrombosis and Haemostasis. 5, 1, p. 55-68

      Research output: Contribution to journalJournal articlepeer-review

    21. 2019
    22. Published

      The developing Entorhinal cortex - a cellular map

      Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Handfield, L., Asenjo Martinez, A., Seemann, Ernst Stefan, Witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Hemberg, M., Pers, Tune H & Hall, Vanessa Jane, 25 Nov 2019. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceCommunication

    23. Published

      Production of stellate cells from induced pluripotent stem cells to study Alzheimer's disease pathology

      Mogus, L., Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Handfield, L., Asenjo Martinez, A., Seemann, Ernst Stefan, Witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Hemberg, M., Pers, Tune H & Hall, Vanessa Jane, 2019. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceCommunication

    24. Published

      Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)

      Cremer, Signe Emilie, Catalfamo, J. L., Goggs, R., Seemann, Ernst Stefan, Kristensen, Annemarie T. & Brooks, M. B., 2019, In: PLoS ONE. 14, 11, e0224891.

      Research output: Contribution to journalJournal articlepeer-review

    25. Published

      RNAcentral: a hub of information for non-coding RNA sequences

      The RNAcentral Constortium , T., Gorodkin, Jan & Seemann, Ernst Stefan, 2019, In: Nucleic Acids Research. 47, D1, p. D221–D229

      Research output: Contribution to journalJournal articlepeer-review

    26. Published

      Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system

      Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, Pers, Tune H & Hall, Vanessa Jane, 2019. 45 p.

      Research output: Contribution to conferencePaperCommunication

    27. Published

      The developing Entorhinal Cortex – a cellular map

      Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Asenjo Martinez, A., Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Pers, Tune H & Hall, Vanessa Jane, 2019.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    28. Published

      Uncovering the anatomical and molecular landscape of the starting point of Alzheimer’s disease in the brain

      Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Asenjo Martinez, A., Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Pers, Tune H & Hall, Vanessa Jane, 2019.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    29. 2018
    30. Published

      Multiple Sequence Alignments Enhance Boundary Definition of RNA Structures

      Sabarinathan, R., Anthon, Christian, Gorodkin, Jan & Seemann, Ernst Stefan, 4 Dec 2018, In: Genes. 9, 12, 17 p., 604.

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Identification and characterization of novel conserved RNA structures in Drosophila

      Kirsch, Rebecca, Seemann, Ernst Stefan, Ruzzo, W. L., Cohen, S. M., Stadler, P. F. & Gorodkin, Jan, 2018, In: BMC Genomics. 19, 20 p., 899.

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      The developmental neurogenic niche of the Entorhinal cortex revealed by single-cell transcriptomics.

      Bergmann, T. B., Liu, Y., Lee, J., Peralvo Vidal, Juan Miguel, Mori, Yuki, Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Gorodkin, Jan, Hall, Vanessa Jane & Pers, Tune H, 2018.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    33. Published

      Uncovering the anatomical and molecular landscape of the developing entorhinal cortex.

      Liu, Y., Bergmann, T. B., Peralvo Vidal, Juan Miguel, Lee, J., Mori, Yuki, Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Gorodkin, Jan, Hyttel, P., Pers, Tune H, witter, M. & Hall, Vanessa Jane, 2018.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    34. 2017
    35. Published

      DotAligner: Identification and clustering of RNA structure motifs

      Smith, M. A., Seemann, Ernst Stefan, Quek, X. C. & Mattick, J. S., Dec 2017, In: Genome Biology. 18, 1, 12 p., 244.

      Research output: Contribution to journalJournal articlepeer-review

    36. Published

      Associating transcription factors and conserved RNA structures with gene regulation in the human brain

      Hecker, N., Seemann, Ernst Stefan, Silahtaroglu, Asli, Ruzzo, W. L. & Gorodkin, Jan, 2017, In: Scientific Reports. 7, 1, 16 p., 5776.

      Research output: Contribution to journalJournal articlepeer-review

    37. Published

      RNAscClust: Clustering RNA sequences using structure conservation and graph based motifs

      Miladi, M., Junge, A., Costa, F., Seemann, Ernst Stefan, Havgaard, Jakob Hull, Gorodkin, Jan & Backofen, R., 2017, In: Bioinformatics. 33, 14, p. 2089-2096 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    38. Published

      The identification and functional annotation of RNA structures conserved in vertebrates

      Seemann, Ernst Stefan, Mirza, A. H., Hansen, C., Bang-Berthelsen, C. H., Garde, C., Christensen-Dalsgaard, M., Torarinsson, E., Yao, Z., Workman, C. T., Pociot, Flemming, Nielsen, Henrik, Tommerup, Niels, Ruzzo, W. L. & Gorodkin, Jan, 2017, In: Genome Research. 27, p. 1371-1383 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    39. 2016
    40. Published

      SNHG5 promotes colorectal cancer cell survival by counteracting STAU1-mediated mRNA destabilization

      Damas, N. D., Marcatti, M., Côme, Christophe Roger Michel, Christensen, L., Nielsen, M. M., Baumgartner, R., Gylling, H. M., Maglieri, G., Friis, Carsten, Seemann, Ernst Stefan, Rapin, N., Thézenas, S., Vang, S., Ørntoft, T., Andersen, C. L., Pedersen, J. S. & Lund, Anders H., 22 Dec 2016, In: Nature Communications. 7, 14 p., 13875.

      Research output: Contribution to journalJournal articlepeer-review

    41. Published

      Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells: [Plus] Corrigendum

      Hölzer, M., Krähling, V., Amman, F., Barth, E., Bernhart, S. H., Carmelo, V. A. O., Collatz, M., Doose, G., Eggenhofer, F., Ewald, J., Fallmann, J., Feldhahn, L. M., Fricke, M., Gebauer, J., Gruber, A. J., Hufsky, F., Indrischek, H., Kanton, S., Linde, J., Mostajo, N. & 19 others, Ochsenreiter, R., Riege, K., Rivarola-Duarte, L., Sahyoun, A. H., Saunders, S. J., Seemann, Ernst Stefan, Tanzer, A., Vogel, B., Wehner, S., Wolfinger, M. T., Backofen, R., Gorodkin, Jan, Grosse, I., Hofacker, I., Hoffmann, S., Kaleta, C., Stadler, P. F., Becker, S. & Marz, M., 7 Oct 2016, In: Scientific Reports. 6, 16 p., 34589.

      Research output: Contribution to journalJournal articlepeer-review

    42. 2015
    43. Published

      Full-length RNA structure prediction of the HIV-1 genome reveals a conserved core domain

      Sükösd, Z., Andersen, E. S., Seemann, Ernst Stefan, Jensen, M. K., Hansen, M., Gorodkin, Jan & Kjems, J., 2 Dec 2015, In: Nucleic Acids Research. 43, 21, p. 10168-79 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    44. Published

      Emerging tools for RNA structure analysis in polymorphic data

      Radhakrishnan, S., Seemann, Ernst Stefan & Gorodkin, Jan, 2015, In: Biozoom. 2, p. 10-13 4 p.

      Research output: Contribution to journalJournal article

    45. Published

      Optimizing RNA structures by sequence extensions using RNAcop

      Hecker, N., Christensen-Dalsgaard, M., Seemann, Ernst Stefan, Havgaard, Jakob Hull, Stadler, P. F., Hofacker, I. L., Nielsen, Henrik & Gorodkin, Jan, 2015, In: Nucleic Acids Research. 43, 17, p. 8135-8145 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    46. Published

      Quality Assessment of Domesticated Animal Genome Assemblies

      Seemann, Ernst Stefan, Anthon, Christian, Palasca, Oana & Gorodkin, Jan, 2015, In: Bioinformatics and Biology Insights. 9, Suppl 4, p. 49-58 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    47. Published

      Transcriptomic landscape of lncRNAs in inflammatory bowel disease

      Mirza, A. H., Bang-Berthelsen, C. H., Seemann, Ernst Stefan, Pan, X., Frederiksen, K. S., Vilien, M., Gorodkin, Jan & Pociot, Flemming, 2015, In: Genome Medicine. 7, 22 p., 39.

      Research output: Contribution to journalJournal articlepeer-review

    48. 2014
    49. Published

      Structured RNAs and synteny regions in the pig genome

      Anthon, Christian, Tafer, H., Havgaard, Jakob Hull, Thomsen, B., Hedegaard, J., Seemann, Ernst Stefan, Pundhir, Sachin, Kehr, S., Bartschat, S., Nielsen, M., Nielsen, R. O., Fredholm, Merete, Stadler, P. F. & Gorodkin, Jan, 2014, In: BMC Genomics. 15, 27 p., 459.

      Research output: Contribution to journalJournal articlepeer-review

    50. 2013
    51. Published

      RNAsnp: efficient detection of local RNA secondary structure changes induced by SNPs: efficient detection of local RNA secondary structure changes induced by SNPs

      Radhakrishnan, S., Tafer, H., Seemann, Ernst Stefan, Hofacker, I. L., Stadler, P. F. & Gorodkin, Jan, 2013, In: Human Mutation. 34, 4, p. 546-556 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    52. Published

      The RNAsnp web server: predicting SNP effects on local RNA secondary structure

      Radhakrishnan, S., Tafer, H., Seemann, Ernst Stefan, Hofacker, I. L., Stadler, P. F. & Gorodkin, Jan, 2013, In: Nucleic Acids Research. 41, p. W475-W479 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    53. 2012
    54. Published

      Sequence and expression analysis of gaps in human chromosome 20

      Minocherhomji, S., Seemann, Ernst Stefan, Mang, Y., Elschich, Z., Bak, M., Hansen, C., Papadopoulos, N., Josefsen, K., Nielsen, Henrik, Gorodkin, Jan, Tommerup, Niels & Silahtaroglu, Asli, Aug 2012, In: Nucleic Acids Research. 40, 14, p. 6660-6672 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    55. Published

      RILogo: visualising RNA-RNA interactions

      Menzel, K. P., Seemann, Ernst Stefan & Gorodkin, Jan, 2012, In: Bioinformatics. 28, 19, p. 2523-2526 4 p.

      Research output: Contribution to journalJournal articlepeer-review

    56. Published

      Transcripts with in silico predicted RNA structure are enriched everywhere in the mouse brain

      Seemann, Ernst Stefan, Sunkin, S. M., Hawrylycz, M. J., Ruzzo, W. L. & Gorodkin, Jan, 2012, In: BMC Genomics. 13, 1, p. 214-227 14 p.

      Research output: Contribution to journalJournal articlepeer-review

    57. 2011
    58. Published

      PETcofold: predicting conserved interactions and structures of two multiple alignments of RNA sequences

      Seemann, Ernst Stefan, Richter, A. S., Gesell, T., Backofen, R. & Gorodkin, Jan, 2011, In: Bioinformatics. 27, 2, p. 211-219 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    59. Published

      The PETfold and PETcofold web servers for intra- and intermolecular structures of multiple RNA sequences

      Seemann, Ernst Stefan, Menzel, K. P., Backofen, R. & Gorodkin, Jan, 2011, In: Nucleic Acids Research. 39, Suppl. 2, p. W107-W111 5 p.

      Research output: Contribution to journalJournal articlepeer-review

    60. 2010
    61. Published

      Hierarchical folding of multiple sequence alignments for the prediction of structures and RNA-RNA interactions

      Seemann, Ernst Stefan, Richter, A. S., Gorodkin, Jan & Backofen, R., 2010, In: Algorithms for Molecular Biology. 5, 22, 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    62. Published

      Prediction of structured non-coding RNAs, RNA-RNA interactions and their (co)-expression in the brain

      Seemann, Ernst Stefan, 2010, Department of Basic Animal and Veterinary Sciences, University of Copenhagen. 195 p.

      Research output: Book/ReportPh.D. thesis

    63. 2008
    64. Published

      Unifying evolutionary and thermodynamic information for RNA folding of multiple alignments

      Seemann, Ernst Stefan, Gorodkin, Jan & Backofen, R., 2008, In: Nucleic Acids Research. 36, 20, p. 6355-6362 8 p.

      Research output: Contribution to journalJournal articlepeer-review

    65. 2007
    66. Published

      Detection of RNA structures in porcine EST data and related mammals

      Seemann, Ernst Stefan, Gilchrist, M. J., Hofacker, I. L., Stadler, P. F. & Gorodkin, Jan, 2007, In: BMC Genomics. 8, 316, 17 p.

      Research output: Contribution to journalJournal articlepeer-review

    ID: 4223622