It is important to identify ways of maintaining high productivity in pig production while keeping antimicrobial use low. The aim of this study was to explore the joint effects between biosecurity, production, vaccine and antimicrobial use. A factor analysis was conducted on biosecurity data collected via computer-assisted telephone interviews and data on a production parameter, purchased vaccines and antimicrobials prescribed in 152 Danish sow herds. Four factors were identified. Factor 1 implied herd type, productivity and antimicrobial use. Factor 2 covered biosecurity. Factor 3 represented focus on foreign employees, cross-fostering and export. Lastly, Factor 4 covered health status and vaccine use. Productivity was positively correlated with antimicrobial use in Factor 1 but did not correlate with vaccination or biosecurity. Thus, when considering future pig production without zinc oxide and a continued focus on reducing antimicrobial use, it is important to consider alternative ways of keeping up a sustainable production.