Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis
Research output: Contribution to journal › Journal article › peer-review
Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.
Original language | English |
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Journal | Gut |
Volume | 49 |
Issue number | 3 |
Pages (from-to) | 387-94 |
Number of pages | 8 |
ISSN | 0017-5749 |
Publication status | Published - 2001 |
- Adult, Aged, Arginine, Blotting, Western, Body Fluids, Case-Control Studies, Colitis, Ulcerative, Confidence Intervals, Female, Humans, Intestinal Absorption, Male, Middle Aged, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type I, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, Statistics, Nonparametric, Tyrosine, Up-Regulation, omega-N-Methylarginine
Research areas
ID: 35922714