Expression of nitric oxide synthases and effects of L-arginine and L-NMMA on nitric oxide production and fluid transport in collagenous colitis

Research output: Contribution to journalJournal articlepeer-review

Luminal nitric oxide (NO) is greatly increased in the colon of patients with collagenous and ulcerative colitis. To define the source and consequence of enhanced NO production we have studied expression of NO synthase (NOS) isoforms and nitrotyrosine in mucosal biopsies from these patients. In addition, effects on colonic fluid transfer caused by manipulating the substrate of NOS were studied in patients with collagenous colitis.
Original languageEnglish
JournalGut
Volume49
Issue number3
Pages (from-to)387-94
Number of pages8
ISSN0017-5749
Publication statusPublished - 2001

    Research areas

  • Adult, Aged, Arginine, Blotting, Western, Body Fluids, Case-Control Studies, Colitis, Ulcerative, Confidence Intervals, Female, Humans, Intestinal Absorption, Male, Middle Aged, Nitric Oxide, Nitric Oxide Synthase, Nitric Oxide Synthase Type I, Nitric Oxide Synthase Type II, Nitric Oxide Synthase Type III, Statistics, Nonparametric, Tyrosine, Up-Regulation, omega-N-Methylarginine

ID: 35922714