Aeromonas salmonicida – A microscopic cause of a major problem: Improving the current vaccines against the cause of furunculosis in rainbow trout

Furunculosis has emerged as one of the major bacterial problems in modern fish farming, or aquaculture.

We are currently building upon our earlier research on vaccinations against this pathogen in order to compose injection vaccines that offer an improved safety profile for the vaccinated fish. Introducing advanced, low-toxicity adjuvants, candidate vaccine formulations will be investigated with respect to induction of immune mechanisms using an array of techniques, including 3D imaging of various organs to investigate tissue specific immune responses, as well as thorough screening for any side effects.Photo of Aeromonas salmonicida

The project is conducted in collaboration with leading scientists in Denmark and Norway, aiming to reduce vaccine induced side effects, while inducing an immune response that provides optimal protection against infection with A. salmonicida.

The project is funded by Det Frie Forskningsråd

For further information contact: Kasper Rømer Villumsen e-mail: krv@sund.ku.dk

Related publications:

Kasper Rømer Villumsen, , Erling Olaf Koppang,  Dennis Christensen, & Anders Miki Bojesen (2017): Alternatives to mineral oil adjuvants in vaccines against Aeromonas salmonicida subsp. salmonicida in rainbow trout offer reductions in adverse effects.
Nature Scientific Reports:7:5930|DOI:10.1038/s41598-017-06324-7 
For a pdf-version of the publikation.

Kasper Rømer Villumsen, Martin Kristian Raida (2013): Long-lasting protection induced by bath vaccination against Aeromonas salmonicida subsp. salmonicida in rainbow trout, Fish & Shellfish Immunology, Volume 35, Issue 5, , Pages 1649-1653, ISSN 1050-4648

Rømer Villumsen K, Dalsgaard I, Holten-Andersen L, Raida MK (2012:) Potential Role of Specific Antibodies as Important Vaccine Induced Protective Mechanism against Aeromonas salmonicida in Rainbow Trout. PLoS ONE 7(10): e46733. doi:10.1371/journal.pone.0046733