The major focus of the lab, involving many both internal and external projects, is the study of the molecular, pathological and functional consequences of marginal (subclinical) vitamin C deficiency (as opposed to chronic severe vitamin C deficiency that inevitably leads to scurvy).
The condition is common in humans but has been given little attention in the literature in spite of overwhelming epidemiological evidence of its consistent association to morbidity. Our two main areas of interest are early brain development and cardiovascular disease.
Our lab is among the leading labs in the world in this particular field. Besides our own research using the guinea pigs as animal model, we participate in many national and international experimental and clinical studies. Other interests within deficiency toxicology include vitamin D deficiency and kwashiorkor.