Oxidative stress in cardiovascular disease, obesity and diabetes

graph illustrating oxidative stress

These projects involve development and validation of biomarkers of oxidative stress in the vasculature in a variety of species (mice, rats, guinea pigs, dogs, pigs, humans) as well as testing drugs and drug candidates in animal models of disease.

Particular emphasis is on oxidative stress in conditions related to the metabolic syndrome cluster and diabetes. Again, both animal models and human studies are carried out with special focus on translational aspects including characterization of model validity.