The heart as a pump: Disease mechanisms and pharmacological interventions

Myxomatous mitral valve disease (MMVD) is a chronic heart disease that leads to degeneration of the mitral valve and chronic mitral regurgitation. The consequences on heart function are deleterious and quality of life is greatly diminished once heart failure is present.

The disease is common in the human population and it is the most common heart disease in dogs. Currently, there is no known therapy capable of halting the progression of the degenerative process.

The research group study disease mechanisms with focus on advanced in vivo imaging, circulating biomarkers and pathology, and possibilities of new treatment options in pigs with experimental induced disease and dogs with naturally occurring disease.