HYPHE: Hybrid Phage Enzybiotics

In HYPHE we explore the huge potential of both known and undiscovered enzymes of phages to redesign these to specifically combat the food borne pathogenic bacteria Campylobacter, Salmonella and E. coli, a concept referred to as enzybiotics.

We identify novel antimicrobial phage enzymes and proteins and their bacterial targets to investigate and use these enzymes for understanding their role in the phage life cycle, and to explore their antimicrobial activities to target gram-negative pathogenic bacteria relevant for food safety.

The project is funded by the Danish Council for Independent Research by 5.9 million Danish Kroner and in this project we collaborate with food consultants for testing our solutions in food. For more information see the homepage of the Danish Research Council.