Phage-bacterial interactions

In order to design efficient phage therapy, knowledge of how phages recognize the bacterial host is required. We therefore work towards finding phage receptors and their phage receptor-binding counterparts.

So far we have identified the first phage receptor in Campylobacter, which is a specific modification of the highly diverse capsular polysaccharides covering the surface of this bacterium. Furthermore, we have shown that other Campylobacter phages are dependent on motile flagella for infection. Receptors of phages infecting Salmonella and E. coli are also currently being identified. Finally, we also study the phage resistance mechanism employed by all of the above bacteria. 

For more information please contact Lone Brøndsted (lobr@sund.ku.dk).