New strategies against antimicrobial and disinfectant resistance

Antimicrobial resistance and reduced efficacy of disinfection are major health and production problems. Our research optimizes use of antibiotics, quantify disinfection problems and investigate synthetic peptides as alternatives to antibiotics.

The research aims to understand how treatment of diseases in production animals, mainly in pigs, influence resistance levels and diversity of selected parts of the microbiota in pigs. The goal is to develop treatment protocols that have high efficacy with minimal influence on resistance levels and diversity of the flora, and which can contribute to overall reduction in the amount of antibiotics used for production of food animals.

Use of disinfectants is postulated to cause selection for antibiotic resistant bacteria. With this in mind, we study tolerance to disinfectants using Salmonella from slaughterhouses as model, and we investigate how adaptation to higher concentration of disinfectant is taking place. Finally, we study the antimicrobial activity of synthetic peptides, and in particular how such peptides affect the target bacteria on a molecular level.

Scientists and students involved in this research are  John E. Olsen, Line E. Thomsen, Camilla Zachariasen Ana H. Fresno.