Metabolism of uropathogenic Escherichia coli and Salmonella during infection

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Metabolic enzymes in bacteria are largely ignored as targets for new antibiotics. Through a detailed characterization of the metabolism of infecting bacteria, we find novel targets for antibiotics.

Bacteria often have several ways to carry out the same metabolic reactions (redundancy). This makes it difficult to identify novel targets for antibiotics in the metabolic network.

To overcome this problem, we determine which metabolic enzymes that form redundant pairs during growth in the animal, and we demonstrate that combined blocking of such pairs is a suitable strategy to block infection.

To do this, we collaborate with scientists at University of Southern Denmark and Brookes University, Oxford, UK in order to model the metabolism based on proteomics of infecting bacteria, and we use the models to predict suitable targets for antibiotics.

Scientists involved in this research are  John Elmerdahl Olsen, Ana Herero-Fresno, Sisse Mortensen, Priscila Guerra and Andreas Eske Johansen.

For more information contact John Elmerdahl Olsen.