Molecular studies of Salmonella interaction with the host
Salmonella enterica causes disease ranging from self-limiting gastroenteritis to systemic and life-threatening infections in both animals and humans. We aim to understand how S. enterica interacts with the host on a molecular level.
We have several ongoing activities within this field:
- We determine why S. Typhimruium clone ST313, which is a major disease problem in humans especially in South Sahara Africa is so virulent
- We try to understand why some types are host specific, for example S. Gallinarum in chicken
- We determine the role of polyamines in Salmonella virulence
- We perform detailed studies of Salmonella metabolism during infection with a focus on redundancy as novel targets for antibiotics, and
- We try to understand the difference between an acute and a chronic infection with respect to Salmonella-host interactions.
To investigate these topics we use genetics, molecular biology, bioinformatics, mathematical modeling, transcriptomics, proteomics, genomics, mammalian cell-cultures and animal models of infection.
For further information, please contact John E. Olsen, Lotte Jelsbak or Ana H. Fresno.