Molecular studies of Salmonella interaction with the host

Salmonella enterica causes disease ranging from self-limiting gastroenteritis to systemic and life-threatening infections in both animals and humans. We aim to understand how S. enterica interacts with the host on a molecular level.

We have several ongoing activities within this field:

  1. We determine why S. Typhimruium clone ST313, which is a major disease problem in humans especially in South Sahara Africa is so virulent
  2. We try to understand why some types are host specific, for example S. Gallinarum in chicken
  3. We determine the role of polyamines in Salmonella virulence
  4. We perform detailed studies of Salmonella metabolism during infection with a focus on redundancy as novel targets for antibiotics, and
  5. We try to understand the difference between an acute and a chronic infection with respect to Salmonella-host interactions.

To investigate these topics we use genetics, molecular biology, bioinformatics, mathematical modeling, transcriptomics, proteomics, genomics, mammalian cell-cultures and animal models of infection.

For further information, please contact John E. Olsen, Lotte Jelsbak or Ana H. Fresno.