BIOCHILD: a joint Danish-Indian strategic research collaboration project – Københavns Universitet

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01. januar 2012

BIOCHILD: a joint Danish-Indian strategic research collaboration project

Professor Haja Kadarmideen and his Indian colleague receive nearly 13.5 million Danish Kroner funding from The Danish Agency for Science, Technology and Innovation (9.5 millions Danish Kroner) and from the Indian Ministry of Science and Technology (4 million Danish Kroner) for a joint Danish-Indian strategic research collaboration project titled, Genetics and Systems Biology of Childhood Obesity in India and Denmark (BIOCHILD).

Professor Haja Kadarmideen receives nearly 9.5 million Danish Kroner from the Programme Commission on Individuals, Disease and Society under the Danish Council for Strategic Research and his Indian partner, Dr. Dwaipayan Bharadwaj, nearly 4 million Danish Kroner from the Department of Biotechnology of Ministry of Science and Technology for a joint Danish-Indian research collaboration project.

Professor Haja Kadarmideen, head of quantitative and systems genetics group at IBHV leads the BIOCHILD consortium that consists of partnership with Novo Nordisk Foundation Center for Basic Metabolic Research and The Children Obesity Clinics at the Holbaek and Ringsted Hospitals in Denmark and Institute of Genomics & Integrative Biology (CSIR) and All India Institute of Medical Sciences (AIIMS), both in New Delhi, India.

Childhood obesity could increase the risk of developing type 2 diabetes and cardiovascular diseases and could lead to high mortality and co-morbidity. In this large strategic research project, around 25 scientific staff from Denmark and India will investigate what genes and DNA variants causes obesity and related metabolic diseases in children from two countries and provide diagnostic genetic markers, prognostic biomarkers, insights into underlying systems biology and mechanisms of gene-based therapy based on individuals genetic make-up.

They will use state-of-the-art Exome Chip to look at one quarter million of DNA variants on the human genome and their relationship with obesity and obesity related biochemical compounds in blood in about 6000 children from India and Denmark. Further, in order, to understand the systems biology and pathogenesis of human obesity and related metabolic syndrome, they will use specifically designed pig obesity model for human obesity that consists of 600 pigs, range of phenotypes, 60,000 DNA markers, gene expression profiles from various tissues. In order to achieve these goals, the project team will develop and apply cutting-edge quantitative-genetics, statistical genetics and systems biology methods and tools.

The research is part of ongoing strategic research collaboration initiatives between Denmark and India, focusing on individual human health and life style diseases.

Main Contact and Principal Investigator: Professor Haja Kadarmideen

Read more about the project here