The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity.
OriginalsprogEngelsk
TidsskriftPlanta Medica
Vol/bind58
Udgave nummer4
Sider (fra-til)334-7
Antal sider4
ISSN0032-0943
DOI
StatusUdgivet - 1992

ID: 43349489