A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS

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Standard

A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS. / Karlskov-Mortensen, Peter.

2009. Poster session presented at The plant and animal genome conference, San Diego, CA, United States.

Research output: Contribution to conference › Poster › Research › peer-review

Harvard

Karlskov-Mortensen, P 2009, 'A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS', The plant and animal genome conference, San Diego, CA, United States, 10/05/2009 - 14/05/2013.

APA

Karlskov-Mortensen, P. (2009). A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS. Poster session presented at The plant and animal genome conference, San Diego, CA, United States.

Vancouver

Karlskov-Mortensen P. A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS. 2009. Poster session presented at The plant and animal genome conference, San Diego, CA, United States.

Author

Karlskov-Mortensen, Peter. / A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS. Poster session presented at The plant and animal genome conference, San Diego, CA, United States.

Bibtex

@conference{f5ba54aaa1264a9db2dc9debaceb9cc1,
title = "A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS",
abstract = "Post-weaning multisystemic wasting syndrome (PMWS) has spread dramatically among pigs over the last years with devastating consequences for animal welfare and great economic losses for farmers. Porcine circovirus 2 (PCV2) is the necessary causal infectious agent of PMWS, but other factors are needed for full development of the disease. Among such factors genetics or breed of pigs have been speculated to play a role and by now several studies have confirmed that breed or boar line is of importance. A linkage study in 14 litters, lead us to the hypothesis that a locus in a region close to microsatellite markers KVL3525 and KVL3526 on porcine chromosome 13 is associated with PMWS development. This was subsequently confirmed by an association study in which KVL3525 was found to be associated with development of PMWS. KVL3525 is located in the middle of the MyRIP gene. This gene encodes a protein involved in transport of vesicles in the cytosol. It is an interesting candidate gene because a number of studies have shown that impaired transport and accumulation of PCV2 in cells of the innate immune system may be an important factor in PMWS pathogenesis. We sequenced MyRIP in PMWS affected and unaffected pigs and identified several single nucleotide polymorphisms (SNPs). However, none of the SNPs were associated with PMWS status.",
author = "Peter Karlskov-Mortensen",
year = "2009",
language = "English",
note = "null ; Conference date: 10-05-2009 Through 14-05-2013",

}

RIS

TY - CONF

T1 - A locus on porcine chromosome 13 harboring the MyRIP gene is associated with development of PMWS

AU - Karlskov-Mortensen, Peter

PY - 2009

Y1 - 2009

N2 - Post-weaning multisystemic wasting syndrome (PMWS) has spread dramatically among pigs over the last years with devastating consequences for animal welfare and great economic losses for farmers. Porcine circovirus 2 (PCV2) is the necessary causal infectious agent of PMWS, but other factors are needed for full development of the disease. Among such factors genetics or breed of pigs have been speculated to play a role and by now several studies have confirmed that breed or boar line is of importance. A linkage study in 14 litters, lead us to the hypothesis that a locus in a region close to microsatellite markers KVL3525 and KVL3526 on porcine chromosome 13 is associated with PMWS development. This was subsequently confirmed by an association study in which KVL3525 was found to be associated with development of PMWS. KVL3525 is located in the middle of the MyRIP gene. This gene encodes a protein involved in transport of vesicles in the cytosol. It is an interesting candidate gene because a number of studies have shown that impaired transport and accumulation of PCV2 in cells of the innate immune system may be an important factor in PMWS pathogenesis. We sequenced MyRIP in PMWS affected and unaffected pigs and identified several single nucleotide polymorphisms (SNPs). However, none of the SNPs were associated with PMWS status.

AB - Post-weaning multisystemic wasting syndrome (PMWS) has spread dramatically among pigs over the last years with devastating consequences for animal welfare and great economic losses for farmers. Porcine circovirus 2 (PCV2) is the necessary causal infectious agent of PMWS, but other factors are needed for full development of the disease. Among such factors genetics or breed of pigs have been speculated to play a role and by now several studies have confirmed that breed or boar line is of importance. A linkage study in 14 litters, lead us to the hypothesis that a locus in a region close to microsatellite markers KVL3525 and KVL3526 on porcine chromosome 13 is associated with PMWS development. This was subsequently confirmed by an association study in which KVL3525 was found to be associated with development of PMWS. KVL3525 is located in the middle of the MyRIP gene. This gene encodes a protein involved in transport of vesicles in the cytosol. It is an interesting candidate gene because a number of studies have shown that impaired transport and accumulation of PCV2 in cells of the innate immune system may be an important factor in PMWS pathogenesis. We sequenced MyRIP in PMWS affected and unaffected pigs and identified several single nucleotide polymorphisms (SNPs). However, none of the SNPs were associated with PMWS status.

M3 - Poster

Y2 - 10 May 2009 through 14 May 2013

ER -

ID: 45680181