The microbiome and rodent models of immune mediated diseases
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The microbiome and rodent models of immune mediated diseases. / Hansen, Axel Kornerup; Hansen, Camilla Hartmann Friis.
In: Mammalian Genome, Vol. 32, 2021, p. 251–262.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The microbiome and rodent models of immune mediated diseases
AU - Hansen, Axel Kornerup
AU - Hansen, Camilla Hartmann Friis
PY - 2021
Y1 - 2021
N2 - Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota. Until 10 years ago the impact of the microbiota on the outcome of rodent studies was ignored, but today it is clear that the phenotype of rodent models differs essentially in relation to the environment of origin, i.e. different breeders or different rooms. In this review, we outline the mechanisms behind gut bacterial impact on rodent models of immune mediated diseases, and how differences in environment of origin leads to phenotypic model differences within research areas such as infectious diseases and vaccine development, the metabolic syndrome, gut immunity and inflammation, autoimmunity and allergy. Finally, we sum up some tools to handle this impact to increase reproducibility and translatability of rodent models.
AB - Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota. Until 10 years ago the impact of the microbiota on the outcome of rodent studies was ignored, but today it is clear that the phenotype of rodent models differs essentially in relation to the environment of origin, i.e. different breeders or different rooms. In this review, we outline the mechanisms behind gut bacterial impact on rodent models of immune mediated diseases, and how differences in environment of origin leads to phenotypic model differences within research areas such as infectious diseases and vaccine development, the metabolic syndrome, gut immunity and inflammation, autoimmunity and allergy. Finally, we sum up some tools to handle this impact to increase reproducibility and translatability of rodent models.
U2 - 10.1007/s00335-021-09866-4
DO - 10.1007/s00335-021-09866-4
M3 - Review
C2 - 33792799
AN - SCOPUS:85103386370
VL - 32
SP - 251
EP - 262
JO - Mammalian Genome
JF - Mammalian Genome
SN - 0938-8990
ER -
ID: 259880793