Cellular mechanisms behind microbial stimulation of APCs

Dependent on specific molecular structures different microbes induce specific immune responses in antigen presenting cells (APCs).

Depending on the specific properties of microorganisms these stimulate APCs such as dendritic cells (DCs) differently, in turn leading to distinct immune responses that efficiently stimulate anti-viral and adaptive immune responses or conversely, lead to a poor immune response, from which the microbe can escape.

Increased knowledge of the cellular and biochemical mechanisms behind an immune response against a microorganism may provide basis for development of new vaccines, treatment of various bacterial infections as well as increased understanding of how probiotics act on the immune system.

We are currently studying the cellular mechanisms induced in DCs upon encounter of different probiotic strains and staphylococci.