Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism
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Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. / Lynes, Matthew D.; Shamsi, Farnaz; Sustarsic, Elahu Gosney; Leiria, Luiz O.; Wang, Chih Hao; Su, Sheng Chiang; Huang, Tian Lian; Gao, Fei; Narain, Niven R.; Chen, Emily Y.; Cypess, Aaron M.; Schulz, Tim J.; Gerhart-Hines, Zachary; Kiebish, Michael A.; Tseng, Yu Hua.
I: Cell Reports, Bind 24, Nr. 3, 2018, s. 781-790.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism
AU - Lynes, Matthew D.
AU - Shamsi, Farnaz
AU - Sustarsic, Elahu Gosney
AU - Leiria, Luiz O.
AU - Wang, Chih Hao
AU - Su, Sheng Chiang
AU - Huang, Tian Lian
AU - Gao, Fei
AU - Narain, Niven R.
AU - Chen, Emily Y.
AU - Cypess, Aaron M.
AU - Schulz, Tim J.
AU - Gerhart-Hines, Zachary
AU - Kiebish, Michael A.
AU - Tseng, Yu Hua
PY - 2018
Y1 - 2018
N2 - Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. In this resource, Lynes et al. use a sensitive MS/MSALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.
AB - Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MSALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure. In this resource, Lynes et al. use a sensitive MS/MSALL technique to profile over 1,000 lipid species in the blood and adipose tissue of humans and mice exposed to cold. Using the online viewer they created to view these data, pathways activated by cold exposure can be identified.
KW - brown adipose tissue
KW - cardiolipin
KW - lipidomics
KW - thermogenesis
KW - white adipose tissue
U2 - 10.1016/j.celrep.2018.06.073
DO - 10.1016/j.celrep.2018.06.073
M3 - Journal article
C2 - 30021173
AN - SCOPUS:85049754305
VL - 24
SP - 781
EP - 790
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 3
ER -
ID: 202371058