Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Because of the extremely polarized morphology, the proper functioning of neurons largely relies on the efficient cargo transport along the axon. Axonal transport defects have been reported in multiple neurodegenerative diseases as an early pathological feature. The discovery of mutations in human genes involved in the transport machinery provide a direct causative relationship between axonal transport defects and neurodegeneration. Here, we summarize the current genetic findings related to axonal transport in neurodegenerative diseases, and we discuss the relationship between axonal transport defects and other pathological changes observed in neurodegeneration. In addition, we summarize the therapeutic approaches targeting the axonal transport machinery in studies of neurodegenerative diseases. Finally, we review the technical advances in tracking axonal transport both in vivo and in vitro.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Seminars in Cell and Developmental Biology |
Vol/bind | 99 |
Sider (fra-til) | 133-150 |
Antal sider | 18 |
ISSN | 1084-9521 |
DOI | |
Status | Udgivet - 2020 |
Eksternt udgivet | Ja |
Bibliografisk note
Funding Information:
Work of the authors was supported by the VIB, the KU Leuven (C1 and “Opening the Future” Fund) , the “Fund for Scientific Research Flanders” (FWO-Vlaanderen) , the Agency for Innovation by Science and Technology (IWT; SBO-iPSCAF) , the Belgian Government (Interuniversity Attraction Poles Programme P7/16 initiated by the Belgian Federal Science Policy Office) , the Thierry Latran Foundation , the “Association Belge contre les Maladies neuro-Musculaires” (ABMM) and the ALS Liga België (A Cure for ALS) . W.G. is supported by a postdoctoral mandate (PDM) fellowship from KU Leuven.
Publisher Copyright:
© 2019 The Authors
ID: 368623300