Alaskan Malamute

Photo: Karsten Bidstrup

Polyneuropathy (PN) – is caused by degeneration of peripheral nerves. This degeneration causes a progressive deterioration of muscles.

In Alaskan Malamute it is a specific mutation in the NDRG1 gene that causes the disease.

The mutation is found in research described in the article:

Bruun, C.S.; Jäderlund, K.H.; Berendt, M.; Jensen, K.B.; Spodsberg, E.H.; Gredal, H.; Shelton, G.D.; Mickelson, J.R:; Minor, K.M.; Lohi, H.; Bjerkås, I.; Stigen, Ø.; Espenes, A.; Rohdin, C.; Edlund, R.; Ohlsson, J.; Cizinauskas, S.; Leifsson, P.S:; Drögemüller, C.; Moe, L.; Cirera, S. and Fredholm, M. (2013): A Gly98Val mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with Polyneuropathy. PLoS One 8(2): e54547. doi: 10.1371

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