We seek to enhance understanding of virus biology spanning from the molecular level to the disease caused in the animal. We have extensive experience in studying animal viruses and continue to use this knowledge to develop improved control measures for the diseases including vaccines.

In a recent study we found large differences in the viral dynamics, pathogenesis and viral shedding in pigs infected with human and swine adapted influenza A viruses. https://doi.org/10.1371/journal.ppat.1011838  

In another study we characterized the pathological and virological findings in seals infected with HPAI viruses.  https://doi.org/10.1111/irv.13208 

We also recently identified the release of high levels of cellular DNA into the blood of ASFV-infected pigs, presumably reflecting large amounts of cell death caused by the virus.  https://doi.org/10.3390/v15102133 

Redskaber til kontrol af virusinfektioner i danske kalve

Samarbejde: Tobias Volhøj, Dyrlæge og Ko 

Formål: At undersøge smittedynamikken og den kliniske betydning af Influenza D virus i danske kalve.

Bevillingsgiver: Kvægafgiftsfonden 1.1.2024-31.12.2024. kr. 749.000.

Redskaber til kontrol af virusinfektioner i danske svin

SEGES Innovation har/har planlagt at indsamle prøver i 2-3 besætninger med henblik på at undersøge effekten af en række management tiltag på reduktion af smittetrykket i farestalden. KU gennemfører de tilknyttede virusundersøgelser.

Sponsor: Svineafgiftsfonden, 1.1.2024-31.12.2024

Avian influenza: Vaccination and molecular biological characterization
The aim of the project is to make research on the efficacy and application of vaccines against highly pathogenic avian influenza viruses (HPAIV). Furthermore, based on viruses sequenced in relation to the passive and active surveillance program for HPAIV in Denmark, detailed phylogenetic analyses will be performed. Furthermore, the project participants will assist in the evaluation of outbreaks in poultry and mammals

Grant: Veterinary contingency program. 2024-25. 4.8 million DKK.

Surveillance of Influenza A virus in Danish pigs

FluZooMark: Viral and Host Factors of Zoonotic and Pandemic Influenza A Viruses
Researchers in virology and immunology in animals and humans will work together to characterize human and animal influenza viruses to find out why some influenza viruses can transmit from swine to humans. The project is expected to generate groundbreaking new tools for preventing future influenza pandemics in humans and provide knowledge that can be used in the future to design improved vaccines for humans and animals.

Funding: Novo Nordisk Foundation Challenge program 2019. 60 mill. DKK.

PIGIE - Understanding the dynamics and evolution of swine influenza viruses in Europe

Researchers from Denmark, France, Germany, Italy, Spain and United Kingdom will perform a longitudinal that will provide essential knowledge for improved intervention and sustainable pig production, and will also be important for further development of more accurate diagnostic tools and relevant vaccines.

Funding: ICRAD; 1,353,000 DKK (1,375,00 EURO in total)

The Biology of Insect-borne Flaviviruses.

These RNA viruses (e.g. West Nile virus) can replicate in insect, avian and mammalian hosts. Infections by these flaviviruses can cause disease and mortality in birds and in a range of different “dead-end” mammalian hosts including horses. Such viruses are spreading across Europe. Currently, there is limited understanding of the basis of host specificity for these viruses, and a lack of tools to follow the adaptation of the virus. In addition, current serological assays for these viruses are hampered by cross-reactivities between them. This project, in close collaboration with SSI, will seek to address some of these issues.

Funding: FVST from the Research Reserve Initiative. 2024-27. ca. 3 mill. DKK

EU Partnership for Animal Health and Welfare (EUP AH&W)- Joint Internal Project OO3-Action 1. 
Basic knowledge on priority pathogens and infectious diseases. The aim is to gain basic knowledge on priority swine pathogens, specifically for us on African swine fever virus. We are performing analyses of gene expression in ASFV-infected cells. 

Funding: 220.000 Euros. 2024-25.

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