Energy metabolism and nutrient oxidation in young pigs and rats during feeding, starvation and re-feeding
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Energy metabolism and nutrient oxidation in young pigs and rats during feeding, starvation and re-feeding. / Chwalibog, André; Jakobsen, Kirsten; Tauson, Anne-Helene; Thorbek, Grete.
In: Comparative Biochemistry and Physiology A, Vol. 140, No. 3, 2005, p. 299-307.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Energy metabolism and nutrient oxidation in young pigs and rats during feeding, starvation and re-feeding
AU - Chwalibog, André
AU - Jakobsen, Kirsten
AU - Tauson, Anne-Helene
AU - Thorbek, Grete
N1 - Kode for udgivelsesland: 'us' Kode for bibliotekets beholdning: 'modtaget' Ukendte organisationer '\'Ernæring\', \'Ernæring\', \'Danish Institute of Agricultural Science\''
PY - 2005
Y1 - 2005
N2 - The investigation included individual measurements of energy metabolism and oxidation of nutrients in 12 castrated male pigs (Sus scrofa) (20-40 kg) and 12 male rats (Rattus norvegicus) (65-105 g). Measurements were carried out in 5-6 days balance periods with ad libitum feeding, followed by 3-4 days of starvation and 4 days of re-feeding. O2 consumption and CO2 production were measured by open-air-circuit respiration units. In the feeding period, protein retention in relation to metabolic live mass (kg(0.75)) was identical for pigs and rats, while there was a tendency of a higher fat retention in pigs than in rats. A substantial part of digested carbohydrate was not oxidized, but transferred to fat metabolism without significant differences (P > 0.05) between pigs and rats (18% vs. 22%). During starvation, nitrogen excretion in urine decreased to 226 mg/kg(0.75) in pigs and to 429 mg/kg(0.75) in rats, indicating a lower rate of body protein degradation in pigs. Heat production was reduced to 592 and 338 kJ/kg(0.75), while the contribution of heat from oxidation of protein (OXP), carbohydrate (OXCHO) and fat (OXF) showed the same pattern for pigs and rats during all periods. Heat production during feeding and re-feeding was covered by OXP+OXCHO with no OXF and reversibly after 2 days of starvation by OXP+OXF with no OXCHO. The rat may be a suitable model for pigs regarding general patterns of quantitative nutrient partition, but any direct application of results measured with rats to pigs shall be taken cautiously, keeping in mind that modern pigs have been selected for a high growth rate and protein deposition which has not been the case for the laboratory rat.
AB - The investigation included individual measurements of energy metabolism and oxidation of nutrients in 12 castrated male pigs (Sus scrofa) (20-40 kg) and 12 male rats (Rattus norvegicus) (65-105 g). Measurements were carried out in 5-6 days balance periods with ad libitum feeding, followed by 3-4 days of starvation and 4 days of re-feeding. O2 consumption and CO2 production were measured by open-air-circuit respiration units. In the feeding period, protein retention in relation to metabolic live mass (kg(0.75)) was identical for pigs and rats, while there was a tendency of a higher fat retention in pigs than in rats. A substantial part of digested carbohydrate was not oxidized, but transferred to fat metabolism without significant differences (P > 0.05) between pigs and rats (18% vs. 22%). During starvation, nitrogen excretion in urine decreased to 226 mg/kg(0.75) in pigs and to 429 mg/kg(0.75) in rats, indicating a lower rate of body protein degradation in pigs. Heat production was reduced to 592 and 338 kJ/kg(0.75), while the contribution of heat from oxidation of protein (OXP), carbohydrate (OXCHO) and fat (OXF) showed the same pattern for pigs and rats during all periods. Heat production during feeding and re-feeding was covered by OXP+OXCHO with no OXF and reversibly after 2 days of starvation by OXP+OXF with no OXCHO. The rat may be a suitable model for pigs regarding general patterns of quantitative nutrient partition, but any direct application of results measured with rats to pigs shall be taken cautiously, keeping in mind that modern pigs have been selected for a high growth rate and protein deposition which has not been the case for the laboratory rat.
KW - Animal Feed
KW - Animal Nutritional Physiological Phenomena
KW - Animals
KW - Dietary Carbohydrates
KW - Dietary Fats
KW - Eating
KW - Energy Metabolism
KW - Male
KW - Nitrogen
KW - Orchiectomy
KW - Oxidation-Reduction
KW - Proteins
KW - Rats
KW - Rats, Wistar
KW - Starvation
KW - Swine
KW - Thermogenesis
U2 - 10.1016/j.cbpb.2005.01.010
DO - 10.1016/j.cbpb.2005.01.010
M3 - Journal article
C2 - 15792595
VL - 140
SP - 299
EP - 307
JO - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
JF - Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
SN - 1095-6433
IS - 3
ER -
ID: 7947519