High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli. / Sadaka, Carmen; Damborg, Peter; Watts, Jeffrey L.

In: Biomolecules, Vol. 8, No. 4, 166, 2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sadaka, C, Damborg, P & Watts, JL 2018, 'High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli', Biomolecules, vol. 8, no. 4, 166. https://doi.org/10.3390/biom8040166

APA

Sadaka, C., Damborg, P., & Watts, J. L. (2018). High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli. Biomolecules, 8(4), [166]. https://doi.org/10.3390/biom8040166

Vancouver

Sadaka C, Damborg P, Watts JL. High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli. Biomolecules. 2018;8(4). 166. https://doi.org/10.3390/biom8040166

Author

Sadaka, Carmen ; Damborg, Peter ; Watts, Jeffrey L. / High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli. In: Biomolecules. 2018 ; Vol. 8, No. 4.

Bibtex

@article{2bbc05e0c6154cb39929964802b96dea,
title = "High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli",
abstract = "Antibiotic discovery is vital when considering the increasing antimicrobial resistance threat. The aim of this work was to provide a high-throughput screen (HTS) assay using multidrug-resistant Escherichia coli strains to enable further research into antimicrobial lead discovery and identify novel antimicrobials. This study describes a primary HTS of a diverse library of 7884 small molecules against a susceptible E. coli strain. A secondary screening of 112 molecules against four E. coli strains with different susceptibility profiles revealed NSC319726 as a potential antimicrobial lead serving as a novel template. NSC319726 is a good candidate for an analoguing program.",
keywords = "Antifolate, Antimicrobial lead, Drug discovery, Escherichia coli, Multidrug resistance, Sulfonamide resistance",
author = "Carmen Sadaka and Peter Damborg and Watts, {Jeffrey L.}",
year = "2018",
doi = "10.3390/biom8040166",
language = "English",
volume = "8",
journal = "Biomolecules",
issn = "2218-273X",
publisher = "MDPI",
number = "4",

}

RIS

TY - JOUR

T1 - High-throughput screen identifying the thiosemicarbazone NSC319726 compound as a potent antimicrobial lead against resistant strains of Escherichia coli

AU - Sadaka, Carmen

AU - Damborg, Peter

AU - Watts, Jeffrey L.

PY - 2018

Y1 - 2018

N2 - Antibiotic discovery is vital when considering the increasing antimicrobial resistance threat. The aim of this work was to provide a high-throughput screen (HTS) assay using multidrug-resistant Escherichia coli strains to enable further research into antimicrobial lead discovery and identify novel antimicrobials. This study describes a primary HTS of a diverse library of 7884 small molecules against a susceptible E. coli strain. A secondary screening of 112 molecules against four E. coli strains with different susceptibility profiles revealed NSC319726 as a potential antimicrobial lead serving as a novel template. NSC319726 is a good candidate for an analoguing program.

AB - Antibiotic discovery is vital when considering the increasing antimicrobial resistance threat. The aim of this work was to provide a high-throughput screen (HTS) assay using multidrug-resistant Escherichia coli strains to enable further research into antimicrobial lead discovery and identify novel antimicrobials. This study describes a primary HTS of a diverse library of 7884 small molecules against a susceptible E. coli strain. A secondary screening of 112 molecules against four E. coli strains with different susceptibility profiles revealed NSC319726 as a potential antimicrobial lead serving as a novel template. NSC319726 is a good candidate for an analoguing program.

KW - Antifolate

KW - Antimicrobial lead

KW - Drug discovery

KW - Escherichia coli

KW - Multidrug resistance

KW - Sulfonamide resistance

U2 - 10.3390/biom8040166

DO - 10.3390/biom8040166

M3 - Journal article

C2 - 30544635

AN - SCOPUS:85058731442

VL - 8

JO - Biomolecules

JF - Biomolecules

SN - 2218-273X

IS - 4

M1 - 166

ER -

ID: 212860448