Modulation of KCNQ4 channel activity by changes in cell volume.
Research output: Contribution to journal › Journal article › Research › peer-review
KCNQ4 channels expressed in HEK 293 cells are sensitive to cell volume changes, being activated by swelling and inhibited by shrinkage, respectively. The KCNQ4 channels contribute significantly to the regulatory volume decrease (RVD) process following cell swelling. Under isoosmotic conditions, the KCNQ4 channel activity is modulated by protein kinases A and C, G protein activation, and a reduction in the intracellular Ca2+ concentration, but these signalling pathways are not responsible for the increased channel activity during cell swelling.
| Original language | English |
|---|---|
| Journal | BBA General Subjects |
| Volume | 1660 |
| Issue number | 1-2 |
| Pages (from-to) | 1-6 |
| Number of pages | 5 |
| ISSN | 0304-4165 |
| DOIs | |
| Publication status | Published - 2004 |
Bibliographical note
Keywords: Calcium; Carbamates; Cell Line; Cell Size; Cyclic AMP-Dependent Protein Kinases; Humans; Indoles; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Osmolar Concentration; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Kinase C; Pyridines; Signal Transduction
ID: 6768730