Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species

Research output: Contribution to journal › Journal article › Research

Standard

Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species. / Bampidis, Vasileios; Azimonti, Giovanna; Bastos, Maria de Lourdes; Christensen, Henrik; Dusemund, Birgit; Durjava, Mojca Fašmon; Kouba, Maryline; López-Alonso, Marta; López Puente, Secundino; Marcon, Francesca; Mayo, Baltasar; Pechová, Alena; Petkova, Mariana; Ramos, Fernando; Sanz, Yolanda; Villa, Roberto Edoardo; Woutersen, Ruud; Cocconcelli, Pier Sandro; Glandorf, Boet; Herman, Lieve; Prieto Maradona, Miguel; Saarela, Maria; Anguita, Montserrat; Galobart, Jaume; Holczknecht, Orsolya; Manini, Paola; Pizzo, Fabiola; Tarrés-Call, Jordi; Pettenati, Elisa; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP).

In: EFSA Journal, Vol. 18, No. 12, e06334, 2020.

Research output: Contribution to journal › Journal article › Research

Harvard

Bampidis, V, Azimonti, G, Bastos, MDL, Christensen, H, Dusemund, B, Durjava, MF, Kouba, M, López-Alonso, M, López Puente, S, Marcon, F, Mayo, B, Pechová, A, Petkova, M, Ramos, F, Sanz, Y, Villa, RE, Woutersen, R, Cocconcelli, PS, Glandorf, B, Herman, L, Prieto Maradona, M, Saarela, M, Anguita, M, Galobart, J, Holczknecht, O, Manini, P, Pizzo, F, Tarrés-Call, J, Pettenati, E & EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) 2020, 'Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species', EFSA Journal, vol. 18, no. 12, e06334. https://doi.org/10.2903/j.efsa.2020.6334

APA

Bampidis, V., Azimonti, G., Bastos, M. D. L., Christensen, H., Dusemund, B., Durjava, M. F., Kouba, M., López-Alonso, M., López Puente, S., Marcon, F., Mayo, B., Pechová, A., Petkova, M., Ramos, F., Sanz, Y., Villa, R. E., Woutersen, R., Cocconcelli, P. S., Glandorf, B., ... EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) (2020). Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species. EFSA Journal, 18(12), [e06334]. https://doi.org/10.2903/j.efsa.2020.6334

Vancouver

Bampidis V, Azimonti G, Bastos MDL, Christensen H, Dusemund B, Durjava MF et al. Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species. EFSA Journal. 2020;18(12). e06334. https://doi.org/10.2903/j.efsa.2020.6334

Author

Bampidis, Vasileios ; Azimonti, Giovanna ; Bastos, Maria de Lourdes ; Christensen, Henrik ; Dusemund, Birgit ; Durjava, Mojca Fašmon ; Kouba, Maryline ; López-Alonso, Marta ; López Puente, Secundino ; Marcon, Francesca ; Mayo, Baltasar ; Pechová, Alena ; Petkova, Mariana ; Ramos, Fernando ; Sanz, Yolanda ; Villa, Roberto Edoardo ; Woutersen, Ruud ; Cocconcelli, Pier Sandro ; Glandorf, Boet ; Herman, Lieve ; Prieto Maradona, Miguel ; Saarela, Maria ; Anguita, Montserrat ; Galobart, Jaume ; Holczknecht, Orsolya ; Manini, Paola ; Pizzo, Fabiola ; Tarrés-Call, Jordi ; Pettenati, Elisa ; EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP). / Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species. In: EFSA Journal. 2020 ; Vol. 18, No. 12.

Bibtex

@article{6a61565589fc4272a9cce6db797319a9,
title = "Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species",
abstract = "Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of concentrated liquid l-lysine (base, minimum 50%) and l-lysine monohydrochloride (HCl, minimum 99%) produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80216) as nutritional additives for all animal species. Neither the production strain nor its recombinant DNA was detected in the final products. The additives do not pose any safety concern associated with the genetic modification of the production strain. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. glutamicumKCCM 80216 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. The concentrated liquid l-lysine (base) and the l-lysine HCl are not irritant to skin or eyes or skin sensitiser. l-lysine HCl is not hazardous by inhalation. l-lysine HCl and concentrated liquid l-lysine (base) are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.",
keywords = "concentrated liquid l-lysine (base), Corynebacterium glutamicum, efficacy, lysine monohydrochloride, nutritional additive, safety, their salts and analogues{\textquoteright}, {\textquoteleft}amino acids",
author = "Vasileios Bampidis and Giovanna Azimonti and Bastos, {Maria de Lourdes} and Henrik Christensen and Birgit Dusemund and Durjava, {Mojca Fa{\v s}mon} and Maryline Kouba and Marta L{\'o}pez-Alonso and {L{\'o}pez Puente}, Secundino and Francesca Marcon and Baltasar Mayo and Alena Pechov{\'a} and Mariana Petkova and Fernando Ramos and Yolanda Sanz and Villa, {Roberto Edoardo} and Ruud Woutersen and Cocconcelli, {Pier Sandro} and Boet Glandorf and Lieve Herman and {Prieto Maradona}, Miguel and Maria Saarela and Montserrat Anguita and Jaume Galobart and Orsolya Holczknecht and Paola Manini and Fabiola Pizzo and Jordi Tarr{\'e}s-Call and Elisa Pettenati and {EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)}",
year = "2020",
doi = "10.2903/j.efsa.2020.6334",
language = "English",
volume = "18",
journal = "E F S A Journal",
issn = "1831-4732",
publisher = "European Food Safety Authority (E F S A)",
number = "12",

}

RIS

TY - JOUR

T1 - Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation with Corynebacterium glutamicum KCCM 80216 as feed additive for all animal species

AU - Bampidis, Vasileios

AU - Azimonti, Giovanna

AU - Bastos, Maria de Lourdes

AU - Christensen, Henrik

AU - Dusemund, Birgit

AU - Durjava, Mojca Fašmon

AU - Kouba, Maryline

AU - López-Alonso, Marta

AU - López Puente, Secundino

AU - Marcon, Francesca

AU - Mayo, Baltasar

AU - Pechová, Alena

AU - Petkova, Mariana

AU - Ramos, Fernando

AU - Sanz, Yolanda

AU - Villa, Roberto Edoardo

AU - Woutersen, Ruud

AU - Cocconcelli, Pier Sandro

AU - Glandorf, Boet

AU - Herman, Lieve

AU - Prieto Maradona, Miguel

AU - Saarela, Maria

AU - Anguita, Montserrat

AU - Galobart, Jaume

AU - Holczknecht, Orsolya

AU - Manini, Paola

AU - Pizzo, Fabiola

AU - Tarrés-Call, Jordi

AU - Pettenati, Elisa

AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)

PY - 2020

Y1 - 2020

N2 - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of concentrated liquid l-lysine (base, minimum 50%) and l-lysine monohydrochloride (HCl, minimum 99%) produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80216) as nutritional additives for all animal species. Neither the production strain nor its recombinant DNA was detected in the final products. The additives do not pose any safety concern associated with the genetic modification of the production strain. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. glutamicumKCCM 80216 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. The concentrated liquid l-lysine (base) and the l-lysine HCl are not irritant to skin or eyes or skin sensitiser. l-lysine HCl is not hazardous by inhalation. l-lysine HCl and concentrated liquid l-lysine (base) are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of concentrated liquid l-lysine (base, minimum 50%) and l-lysine monohydrochloride (HCl, minimum 99%) produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80216) as nutritional additives for all animal species. Neither the production strain nor its recombinant DNA was detected in the final products. The additives do not pose any safety concern associated with the genetic modification of the production strain. Concentrated liquid l-lysine (base) and l-lysine HCl produced by C. glutamicumKCCM 80216 do not represent a risk for the target species, the consumer and the environment. From the results of studies on the safety for the user of concentrated liquid l-lysine (base) and l-lysine HCl produced by a different production strain, it was possible to conclude on the safety for the user of the products under assessment. The concentrated liquid l-lysine (base) and the l-lysine HCl are not irritant to skin or eyes or skin sensitiser. l-lysine HCl is not hazardous by inhalation. l-lysine HCl and concentrated liquid l-lysine (base) are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

KW - concentrated liquid l-lysine (base)

KW - Corynebacterium glutamicum

KW - efficacy

KW - lysine monohydrochloride

KW - nutritional additive

KW - safety

KW - their salts and analogues’

KW - ‘amino acids

U2 - 10.2903/j.efsa.2020.6334

DO - 10.2903/j.efsa.2020.6334

M3 - Journal article

C2 - 33343731

AN - SCOPUS:85098236349

VL - 18

JO - E F S A Journal

JF - E F S A Journal

SN - 1831-4732

IS - 12

M1 - e06334

ER -

ID: 259989545