Temperate Phages of Staphylococcus aureus
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Temperate Phages of Staphylococcus aureus. / Ingmer, Hanne; Gerlach, David; Wolz, Christiane.
In: Microbiology Spectrum, Vol. 7, No. 5, 2019, p. 1-18.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Temperate Phages of Staphylococcus aureus
AU - Ingmer, Hanne
AU - Gerlach, David
AU - Wolz, Christiane
PY - 2019
Y1 - 2019
N2 - Most Staphylococcus aureus isolates carry multiple bacteriophages in their genome, which provide the pathogen with traits important for niche adaptation. Such temperate S. aureus phages often encode a variety of accessory factors that influence virulence, immune evasion and host preference of the bacterial lysogen. Moreover, transducing phages are primary vehicles for horizontal gene transfer. Wall teichoic acid (WTA) acts as a common phage receptor for staphylococcal phages and structural variations of WTA govern phage-host specificity thereby shaping gene transfer across clonal lineages and even species. Thus, bacteriophages are central for the success of S. aureus as a human pathogen.
AB - Most Staphylococcus aureus isolates carry multiple bacteriophages in their genome, which provide the pathogen with traits important for niche adaptation. Such temperate S. aureus phages often encode a variety of accessory factors that influence virulence, immune evasion and host preference of the bacterial lysogen. Moreover, transducing phages are primary vehicles for horizontal gene transfer. Wall teichoic acid (WTA) acts as a common phage receptor for staphylococcal phages and structural variations of WTA govern phage-host specificity thereby shaping gene transfer across clonal lineages and even species. Thus, bacteriophages are central for the success of S. aureus as a human pathogen.
U2 - 10.1128/microbiolspec.GPP3-0058-2018
DO - 10.1128/microbiolspec.GPP3-0058-2018
M3 - Journal article
C2 - 31562736
AN - SCOPUS:85072694301
VL - 7
SP - 1
EP - 18
JO - Microbiology spectrum
JF - Microbiology spectrum
SN - 2165-0497
IS - 5
ER -
ID: 228489955