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Stine Brandt Bering

Stine Brandt Bering

Associate Professor

Current Projects:

Mild-heat-treated bovine whey protein concentrate as a supplement for infant formula and donor human milk

The project is partly financed by The Danish Milk Levy Board/The Dairy Research Foundation (2015-16).Human milk is designed to provide optimal nutrition and protection from pathogens and food antigens for newborn infants by providing not only nutrients, but also growth factors and immunosuppressive factors that protect against inflammation and infection. These bioactive components are particularly important when the gut is immature or sensitive to infection, such as in preterm infants. Donor human milk (DM) and/or infant formula are the alternatives when mother’s own milk is not available. DM is the preferred alternative, but as infant formula, DM is pasteurized, leading to a decrease in the bioactivity of these important milk proteins. Furthermore, there is often a need to supplement mature DM, which contains lower amounts of protein than the early milk, with extra protein. A quality concentrate of bovine milk with conserved bioactivity would be of particular interest. In this project we investigate if a mild heat-treatment of bovine whey protein concentrate (WPC) and raw DM increase maturation and protection of the newborn intestine compared to normal pasteurization. Furthermore, the physiological effects of WPC compared to DM will be investigated. This will be investigated in a pig model of intestinal inflammation in preterm neonates with supplementing bioactivity studies in cell models. The results have implications for treatment of milk products for sensitive newborn infants as well as for more robust children. 

Academic profile, in brief:

Research focus is on nutrition in relation to gastrointestinal development and immune regulation, particularly in early life. Methods include in vivo animal models, human studies, and development of in vitro cell models and ex vivo tissue studies to clarify specific intestinal responses and cellular mechanisms. Nutrients of interest are bioactive compounds, pre- and probiotics and human milk oligosaccharides to regulate the immune system and intestinal functions.

Academic degrees:

2006: PhD in Human Nutrition, Dept. Human Nutrition, Faculty of Life Sciences, University of Copenhagen.

2001: MSc in Chemical Engineering, The Technical University of Denmark.

Academic employment:

2015 - present: Associate Professor, Dept. Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen.

2011 - 2015: Associate Professor, Dept. Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen.

2006 – 2011: Assistant Professor, Dept. Human Nutrition, Faculty of Life Sciences, University of Copenhagen.

2001-2006: PhD student, Dept. Human Nutrition, Faculty of Life Sciences, University of Copenhagen.

Selected publications

  1. Published

    The incidence of necrotizing enterocolitis is increased following probiotic administration to preterm pigs

    Cilieborg, M. S., Thymann, T., Siggers, R. H., Boye, M., Bering, S. B., Jensen, B. B. & Sangild, P. T., 2011, In : Journal of Nutrition. 141, 2, p. 223-230 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    IUGR does not predispose to necrotizing enterocolitis or compromise postnatal intestinal adaptation in preterm pigs

    Che, L., Thymann, T., Bering, S. B., Huërou-Luron, I. L., D'Inca, R., Zhang, K. & Sangild, P. T., 2010, In : Pediatric Research. 67, 1, p. 54-59 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Carbohydrate maldigestion induces necrotizing enterocolitis in preterm pigs

    Thymann, T., Møller, H. K., Stoll, B., Støy, A. C. F., Buddington, R. K., Bering, S. B., Jensen, B. B., Olutoye, O. O., Siggers, R. H., Mølbak, L., Sangild, P. T. & Burring, D. G., 2009, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 297, 6, p. G1115-G1125 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Aldohexose malabsorption in preterm pigs is directly related to the severity of necrotizing enterocolitis

    Buddington, R. K., Bering, S. B., Thymann, T. & Sangild, P. T., 2008, In : Pediatric Research. 63, 4, p. 382-387 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Viable, lyophilized lactobacilli do not increase iron absorption from a lactic acid-fermented meal in healthy young women, and no iron absorption occurs in the distal intestine

    Bering, S. B., Sjøltov, L. B., Wrisberg, S. S., Berggren, A., Alenfall, J., Jensen, M., Højgaard, L., Tetens, I. & Bukhave, K., 2007, In : British Journal of Nutrition. 98, 5, p. 991-997 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The effect of Lactobacillus Plantarum 299V and lactic acid on iron bioavailability: in vitro and human studies

    Bering, S. B., 2006, Frederiksberg: Center for Skov, Landskab og Planlægning/Københavns Universitet. 129 p.

    Research output: Book/ReportPh.D. thesisResearch

  7. Published

    A lactic acid-fermented oat gruel increases non-haem iron absorption from a phytate-rich meal in healthy women of childbearing age

    Bering, S. B., Suchdev, S., Sjøltov, L., Berggren, A., Tetens, I. & Bukhave, K., 2006, In : British Journal of Nutrition. 96, 1, p. 1-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Development of a three-tier in vitro system, using Caco-2 cells, to assess the effects of lactate on iron uptake and transport from rye bread following in vitro digestion

    Bering, S. B., Bukhave, K., Henriksen, M., Sandström, B., Pariagh, S., Fairweather-Tait, S. J. & Lund, E. K., 2006, In : Journal of the Science of Food and Agriculture. 86, 14, p. 2438-2444 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The usefulness of In vitro models to predict the bioavailability if iron and zinc: a consensus statement from the HarvestPlus expert consultation

    Fairweather-Tait, S., Lynch, S., Hotz, C., Hurrell, R., Abrahamse, L., Beebe, S., Bering, S. B., Bukhave, K., Glahn, R., Hambidge, M., Hunt, J., Lonnerdal, B., Miller, D., Mohktar, N., Nestel, P., Reddy, M., Sandberg, A-S., Sharp, P., Teucher, B. & Trinidad, T. P., 2005, In : International Journal of Vitamin and Nutrition Research. 75, 6, p. 371-374 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4954516