Kristine Freude

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My research interests are centered on neurodegenerative and neurodevelopmental diseases. In my group we are implementing induced pluripotent cells (iPSC) from humans and animals to understand disease mechanisms leading to neurodegenerative and neurodevelopmental diseases.

The research on human iPSC models for neurodegenerative diseases encompasses Alzheimer’s disease (AD), Frontotemporal dementia (FTD) and Glaucoma. Furthermore, we are working with canine iPSC to understand commonalities and divergences between human AD and canine cognitive dysfunction (CCD) also known as dog dementia.

Our research on neurodevelopmental disorders is focused on implementing human iPSC models for epilepsy and schizophrenia.

Additionally, besides the canine iPSC, we are working with porcine and monkey iPSC. The establishment of these in vitro iPSC models is aimed in combination with organoid models at replacing and refining the need for in vivo animal models.

Current funding sources:

Danish Research Council (FNU); Novo Nordisk Foundation; Lundbeck Foundation, Velux Foundation, Hørslev Foundation