Section for Pathobiological Sciences

The research group of Experimental Pathology studies artificially induced, or naturally occurring, pathological processes through macroscopic and microscopic examinations of organs, tissues and cells. The vision is to reveal and visualize disease mechanisms of both human and animal diseases and, thereby, contribute to development of new diagnostic, prognostic, prophylactic and therapeutic technologies. Our missions are:

• To develop animal models of human diseases and characterize them comprehensively through macroscopic and microscopic investigations. 
• To apply animal models of human diseases in diagnostic, prognostic, prophylactic and therapeutic studies.
• To use molecular pathology to identify and investigate disease mechanisms in well characterized animal models, or in tissue samples from animals or humans with a specific natural occurring disease of interest.

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Research area: Contingency and notifiable animal diseases, diagnostics of and surveillance of fur animals, wild life pathology and surveillance, gut health and microbiota, wound infections and biofilm in wounds, alternatives to antibiotics (probiotica, wound treatment, selection and immunological toughness). 

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Research area: Our group is focused on disease modelling using state of the art stem cell approaches for neurodegenerative diseases (Alzheimer’s disease, Frontotemporal dementia, Parkinson’s disease), Epilepsy and Glaucoma. These projects work with human induced pluripotent stem cells (iPSC), CRISPR/Cas9 gene editing neuronal and glial differentiation and downstream analyses in 2D and 3D organoids.

Likewise, we are interested in iPSC models from animals and we are running projects making canine iPSC to understand and make in vitro models of canine cognitive dysfunction as well as making immune-evasive porcine iPSC to improve transplantation studies.

Our research on cerebral vascular (dys-)function in hypertension, aging and obesity/diabetes is focused on their significance as risk factors for several types of dementia, including vascular dementia and Alzheimer’s Disease.

Our focus in embryology is on early events in oocyte and sperm development, reproduction and manipulation of such events to increase life stock sustainability and animal welfare. 

• Associate professor Kristine Freude - Stem Cells Models for Studies of Neurodegenerative Diseases
• Associate professor Lars Jørn Jensen - Cerebrovascular Physiology

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Research area: The group of Brain Development and Disease’s primary vision is to determine novel mechanisms involved in neurodevelopment and neurodegenerative diseases. Our primary research is currently focused on the cellular mapping of the developing entorhinal cortex (the brain’s spatial navigation and processing system). We also use pluripotent and neural stem cells, as well brains from the human and pig to model human brain development and to investigate diseases, such as Alzheimer’s disease. The group incorporates cutting edge technologies, including, single cell RNA sequencing and direct programming of stem cells to produce different brain cells in a dish from both healthy and diseased individuals.

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Research areas; We have a shared interest in excitable cells and contractile tissue. The research in this group falls into two main categories: Excitable Cells and Biomechanics.

Exitable Cells

The molecular basis for the transport of ions, water and nutrients, ion channels, electrophysiology, pharmacological treatment, action potentials, cardiac arrhythmias, epilepsy, migraine, evolution of the electrical signaling in the mammalian heart, stem cells derived organoids

Biomechanics

Fascia, locomotor system, biomechanics, lateral raphe, thoracolumbar fascia, acoustic myography, multi-frequency bioimpedance, isolated tissue bath studies, rheumatology, sports medicine, geriatrics, structural anatomy and pathology

• Associate professor Kirstine Callø,
• Professor Dan Klærke,
• Associate professor Vibeke Sødring Elbrønd,
• Associate professor Adrian Harrison
• Associate professor Jessica Pingel

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