Section for Pathobiological Sciences

The section for Pathobiological Sciences (PAS) is a part of the Department for Veterinary and Animal Sciences (IVH) at the University of Copenhagen.

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 PAS is dedicated to;

  • Research on a high, international level within neuroanatomy, neurodegenerative disorders, electrophysiology, the cardiovascular system, biomechanics, animal welfare, disease models, pathogenesis evaluation, veterinary pathologist diagnostics.

    We have established pluripotent (iPSC) stem cells from animals and humans and used CRISPR/Cas9 to develop in vitro models for neuronal and cardiac tissue. We have advanced electrophysiological technics including patch clamp from brain slices, multiple electrodes arrays and bio-impedance recorders. We have developed experimental for testing novel antibiotics ability to prevent biofilm formation on bone implants.

    For a more information, please follow the links below.

  • Veterinary Contingency, partly consulting cases for the Danish Veterinary and Food Administration, partly veterinary Contingency which receives all cadavers and organs for observation of notifiable animal diseases. Furthermore we are responsible for the surveillance of cattle abortion and the surveillance of TSE (BSE and scrapie) in Denmark.
    • Teaching. The teaching of the section is vital to the veterinary bachelor and master programme as well as to the Animal Science programme. We prepare the students for research, diagnostics and clinical work. We educate master students and PhD students on a high, international level within the research areas of the section.
       
      • Students are welcome to contact us for available projects.

      Research Groups

      The section consists of 6 research groups: Veterinary Pathology, Experimental Pathology, Pathology of small animals and wild life, Disease Stem Cell Models and Embryology, Brain Development and Disease and Physiology. 

       

       

       

       

       

      Drawing of the entrance to pathologyResearch areas: Animal welfare, lesions and inflammation, animal diseases, diagnostic pathology, comparative infection pathology, fungi, virus, parasite and bacteria infections, animal models, implants, biofilm and alternatives for antibiotics. 

      • Professor Henrik Elvang Jensen,
      • Associate professor Páll Leifsson,
      • Associate professor Mette Sif Hansen,
      • Assistant professor Kristiane Barington

      READ MORE


       

       

      The research group of Experimental Pathology studies artificially induced, or naturally occurring, pathological processes through macroscopic and microscopic examinations of organs, tissues and cells. The vision is to reveal and visualize disease mechanisms of both human and animal diseases and, thereby, contribute to development of new diagnostic, prognostic, prophylactic and therapeutic technologies. Our missions are:

      • To develop animal models of human diseases and characterize them comprehensively through macroscopic and microscopic investigations. 
      • To apply animal models of human diseases in diagnostic, prognostic, prophylactic and therapeutic studies.
      • To use molecular pathology to identify and investigate disease mechanisms in well characterized animal models, or in tissue samples from animals or humans with a specific natural occurring disease of interest.

      Read more about the group

       

       

      Research area: Contingency and notifiable animal diseases, diagnostics of and surveillance of fur animals, wild life pathology and surveillance, gut health and microbiota, wound infections and biofilm in wounds, alternatives to antibiotics (probiotica, wound treatment, selection and immunological toughness). 

      READ MORE (in Danish)


       

       

      Research area: Our group is focused on disease modelling using state of the art stem cell approaches for neurodegenerative diseases (Alzheimer’s disease, Frontotemporal dementia, Parkinson’s disease), Epilepsy and Glaucoma. These projects work with human induced pluripotent stem cells (iPSC), CRISPR/Cas9 gene editing neuronal and glial differentiation and downstream analyses in 2D and 3D organoids.

      Likewise, we are interested in iPSC models from animals and we are running projects making canine iPSC to understand and make in vitro models of canine cognitive dysfunction as well as making immune-evasive porcine iPSC to improve transplantation studies.

      Our research on cerebral vascular (dys-)function in hypertension, aging and obesity/diabetes is focused on their significance as risk factors for several types of dementia, including vascular dementia and Alzheimer’s Disease.

      Our focus in embryology is on early events in oocyte and sperm development, reproduction and manipulation of such events to increase life stock sustainability and animal welfare. 

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      Research area: The group of Brain Development and Disease’s primary vision is to determine novel mechanisms involved in neurodevelopment and neurodegenerative diseases. Our primary research is currently focused on the cellular mapping of the developing entorhinal cortex (the brain’s spatial navigation and processing system). We also use pluripotent and neural stem cells, as well brains from the human and pig to model human brain development and to investigate diseases, such as Alzheimer’s disease. The group incorporates cutting edge technologies, including, single cell RNA sequencing and direct programming of stem cells to produce different brain cells in a dish from both healthy and diseased individuals.

      READ MORE

       

       

      Research areas; We have a shared interest in excitable cells and contractile tissue. The research in this group falls into two main categories: Excitable Cells and Biomechanics.

      Exitable Cells

      The molecular basis for the transport of ions, water and nutrients, ion channels, electrophysiology, pharmacological treatment, action potentials, cardiac arrhythmias, epilepsy, migraine, evolution of the electrical signaling in the mammalian heart, stem cells derived organoids

      Biomechanics

      Fascia, locomotor system, biomechanics, lateral raphe, thoracolumbar fascia, acoustic myography, multi-frequency bioimpedance, isolated tissue bath studies, rheumatology, sports medicine, geriatrics, structural anatomy and pathology

      • Associate professor Kirstine Callø,
      • Professor Dan Klærke,
      • Associate professor Vibeke Sødring Elbrønd,
      • Associate professor Adrian Harrison
      • Associate professor Jessica Pingel

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      We have highly specialised Core facilities which perform diagnostic pathology, stem cell technologies.

      Pathology CORE

      The Histo-Laboratory assists scientists in processing tissue samples for histochemical and molecular based procedures. In the Histo-Laboratory state-of the art histotechnology is offered by a team of specialized technicians.

      In research projects, optimal results are obtained when the laboratory is contacted as early as possible in the planning of the in vivo part of the project; allowing the technicians to help determine how histological approach can best support the research aim.

      Paraffin embedding, sectioning and staining of tissues. Embedding and sectioning services are based on standard protocols. Tissues are fixed and embedded in paraffin blocks, which are used for a variety of analyses, e.g., histochemical staining (HE, PAS, GMS etc.), immunohistochemistry (IHC), and in-situ hybridization (ISH), PCR, etc. Apart from stained sections, also paraffin blocks and the unstained sections can be provided. 

      Kontakt: Betina Andersen, bean@sund.ku.dk eller Elisabeth Petersen, ewp@sund.ku.dk. Tlf 35333106.


      Veterinary contingency

      Contact information:

      The veterinary contingency - phone number 9350 9280 - can be contacted 8:00-16:00 on working days. 

      Non urgent inquiries can be mailed to: kupat@sund.ku.dk  

      Contact person: Anne- Sofie Hammer, hammer@sund.ku.dk


      Stem cell and TEM core


      Anubis Core

       

      Head of Section Kirstine Callø

      Head of Section

      Kirstine Callø
      Associate Professor

      Phone +45 61 66 64 02
      kirstinec@sund.ku.dk

      Employees at Section

      Internal researchers

      Name Title Phone E-mail
      Al-Jubury, Azmi External, Ph.d Student +4535334117 E-mail
      Andersen, Betina Gjedsted Biomedical Laboratory Scientist +4535336737 E-mail
      Andersen, Frederik Attendant FU +4535336735 E-mail
      Anex, Genevieve Aline Visiting Student   E-mail
      Barington, Kristiane Assistant Professor +4535333112 E-mail
      Becker, Cecilie Brandt Research Assistant +4535337580 E-mail
      Bendtsen, Katja Maria Sahlgren Research Assistant   E-mail
      Birch, Julie Knippel Melsted Postdoc +4535334728 E-mail
      Blirup-Plum, Sophie Amalie PhD Fellow +4535331513 E-mail
      Blok-Husum, Emma Teacher´s Assistant   E-mail
      Bostrom, Emily Rose Visiting Student   E-mail
      Bredum, Simon Krogh Veterinarian   E-mail
      Brok, Dennis Attendant FU +4535333101 E-mail
      Cakal, Selgin Deniz External, Ph.d Student +4581930536 E-mail
      Callø, Kirstine Associate Professor +4561666402 E-mail
      Chandrasekaran, Abinaya Assistant Professor +4535328080 E-mail
      Christensen, Jonathan Ingerslev Teacher´s Assistant   E-mail
      Christensen, Vibeke Grøsfjeld Laboratory Technician +4535332562 E-mail
      Christiansen, Ida Højager Attendant FU   E-mail
      Derian, Nicolas External   E-mail
      Eiersted, Anna Cecilie Boldt Laboratory Technician +4535337069 E-mail
      Elbrønd (Bibs), Vibeke Sødring Associate Professor +4535332548 E-mail
      Fenner, Merle Friederike Assistant Professor +4535333300 E-mail
      Freude, Kristine Associate Professor +4535330937 E-mail
      Gad, Mathilde Teacher´s Assistant   E-mail
      Gulmann, Adam Teacher´s Assistant   E-mail
      Hall, Vanessa Jane Associate Professor +4535332512 E-mail
      Hammer, Anne Sofie Vedsted Associate Professor +4535333129 E-mail
      Hansen, Line Sofia Nordahl Teacher´s Assistant   E-mail
      Hansen, Mette Sif Associate Professor +4535326468 E-mail
      Hansen, Vibeke Bøgelund Attendant +4523828066 E-mail
      Harrison, Adrian Paul Associate Professor +4561462732 E-mail
      Hartmann, Katrine Top PhD Fellow +4535331206 E-mail
      Haukedal, Henriette Postdoc +4535325288 E-mail
      Holm, Peter Associate Professor +4535332885 E-mail
      Hovmand-Hansen, Trine PhD Fellow +4535331443 E-mail
      Hvidtfeldt, Esther Johanne Teacher´s Assistant   E-mail
      Jensen, Betina Wingreen Special Consultant +4535334704 E-mail
      Jensen, Henrik Elvang Professor +4535333100 E-mail
      Jensen, Jan Lykke Attendant +4523828065 E-mail
      Jensen, Lars Jørn Associate Professor +4535332563 E-mail
      Jensen, Louise Kruse Associate Professor +4535336192 E-mail
      Jensen, Maibritt Træholt Veterinarian +4535330362 E-mail
      Jørgensen, Benjamin Meyer Research Assistant   E-mail
      Jørgensen, Mads Neergaard Teacher´s Assistant   E-mail
      Kadlecová, Marion PhD Fellow +4535332030 E-mail
      Klærke, Dan Arne Professor +4535332511 E-mail
      Kragh, Benedicte Section Secretary +4535333105 E-mail
      Kromann, Sofie Industrial PhD +4535326918 E-mail
      Larsen, Jakob Overgaard Teacher´s Assistant +4528727717 E-mail
      Leifsson, Páll Skúli Associate Professor +4535333114 E-mail
      Lindberg, Lucas Alexander Teacher´s Assistant   E-mail
      Magnusson, Helena Bøgeholm Dehn PhD Fellow +4535333338 E-mail
      Mohamed, Fadumo Abdullahi PhD Fellow +4535325198 E-mail
      Moss, Keith Henry Guest Researcher   E-mail
      Møller, Henrik D. External   E-mail
      Møller, Steffen Kjær Hemmingsen Teacher´s Assistant   E-mail
      Møller-Petersen, Mathilde Luth Teacher´s Assistant   E-mail
      Olesen, Sasja Teacher´s Assistant   E-mail
      Pankoke, Karen PhD Student   E-mail
      Petersen, Elisabeth Wairimu Laboratory Technician +4535336757 E-mail
      Petersen, Johanne Essy Teacher´s Assistant   E-mail
      Pihl, Maria Laboratory Technician +4522496408 E-mail
      Pingel, Jessica External +4535327338 E-mail
      Quaade, Michelle Lauge PhD Fellow +4535334685 E-mail
      Ralbovszki, Dorottya Maria PhD Fellow +4535325434 E-mail
      Randall, Andrew David Guest Researcher   E-mail
      Saruhanian, Sarkis PhD Fellow +4535327472 E-mail
      Synnestvedt, Josefine Natalie Teacher´s Assistant   E-mail
      Sønderby, Laura Teacher´s Assistant   E-mail
      Tao, Ruixin PhD Student   E-mail
      Thomsen, Preben Dybdahl Professor +4535332545 E-mail
      Van der Graaff, Elisabeth M Student   E-mail
      Wandall, Jakob Research Assistant +4535337633 E-mail
      Wolf-Jäckel, Godelind Alma Assistant Professor +4535320521 E-mail