The Jensen Group
Arteriolar function in the brain
- We investigate fundamental mechanisms in regulation of arteriolar tone involved in the control of blood pressure and organ perfusion, mainly the brain.
- We specialize in myogenic tone, flow-mediated vasodilatation, and structural remodeling, which are key determinants of vascular function in vivo.
- We strive to describe new molecular mechanisms, and to apply this research using animal models of hypertension, aging and obesity/diabetes.
- In collaboration with Novo Nordisk and the LifePharm In Vivo Pharmacology Centre, we assist in development of porcine models of obesity and diabetes through our expertise in microvascular function.
- Currently we have projects with an emphasis on brain perfusion in relation to calcium channels and Rho-kinase in aging and neurodegenerative diseases.
- We are also actively investigating the role of arteriolar K+ channels and insulin signaling in diet-induced hypertension and obesity as a model of the human metabolic syndrome.
- Funding has mainly been obtained from DFF, Novo Nordisk Foundation, Hjerteforeningen, Lundbeck Foundation, and Fonden til Lægevidenskabens Fremme (AP Møller).
Fig. 1: The Myogenic Response (from Björling et al, 2018):
Fig. 2: Cerebral (pial) arteriole with myogenic tone (at 60 mm Hg) from the brain of a Göttingen minipig:
Fig. 3: Rho-kinase 2 inhibitor KD025 blocks myogenic tone in cerebral arteriole from Göttingen minipig (Björling et al, 2018):
Fig. 4: Flow-mediated vasodilatation in lean vs. hypertensive obese rats (Gradel et al, 2018):
Fig. 5: Isolated endothelial tube from mouse small mesenteric artery (for quantitative real-time PCR):