The Jensen Group

Group focus

Arteriolar function in the brain

  • We investigate fundamental mechanisms in regulation of arteriolar tone involved in the control of blood pressure and organ perfusion, mainly the brain.
  • We specialize in myogenic tone, flow-mediated vasodilatation, and structural remodeling, which are key determinants of vascular function in vivo.
  • We strive to describe new molecular mechanisms, and to apply this research using animal models of hypertension, aging and obesity/diabetes.
  • In collaboration with Novo Nordisk and the LifePharm In Vivo Pharmacology Centre, we assist in development of porcine models of obesity and diabetes through our expertise in microvascular function.

Current projects

  • Currently we have projects with an emphasis on brain perfusion in relation to calcium channels and Rho-kinase in aging and neurodegenerative diseases.
  • We are also actively investigating the role of arteriolar K+ channels and insulin signaling in diet-induced hypertension and obesity as a model of the human metabolic syndrome.
  • Funding has mainly been obtained from DFF, Novo Nordisk Foundation, Hjerteforeningen, Lundbeck Foundation, and Fonden til Lægevidenskabens Fremme (AP Møller).

Selected publications

  1. Björling K, Joseph PD, Egebjerg K, Salomonsson M, Hansen JL, Ludvigsen TP, and Jensen LJ. Role of age, Rho-kinase 2 expression, and G protein-mediated signaling in the myogenic response in mouse small mesenteric arteries. Physiol. Rep. 6(17), e13863 (2018).
  2. Klein A, Joseph PD, Christensen VG, Jensen LJ, and Jacobsen JCB. Lack of Tone in Mouse Small Mesenteric Arteries Leads to Outward Remodeling, which can be Prevented by Prolonged Agonist-Induced Vasoconstriction. Am . J. Physiol. (Heart Circ. Physiol.): 315(3):H644-H657, 2018. (IF 3.569).
  3. Gradel AKJ, Salomonsson M, Sørensen CM, Holstein-Rathlou N-H, and Jensen LJ. Long-term diet-induced hypertension in rats is associated with reduced expression and function of small artery SKCa, IKCa, and Kir2.1 channels. Clinical Science 132, 461-474, 2018 (IF 4.936).
  4. Mikkelsen MF, Björling K and Jensen LJ. Age-dependent impact of CaV3.2 T-type calcium channel deletion on myogenic tone and flow-mediated vasodilatation in small arteries. J. Physiol. 594.20:5881–5898, 2016. (IF 4.731 – Level 2)
  5. Boonen HCM, Moesgaard SG, Birck MM, Christoffersen BØ, Cirera S, Heegaard PMH, Højbøge TR, Jensen LJ, Mortensen A, Olsen LH, Sheykhzade M, Tang J and Lykkesfeldt J. Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs. Pflugers Arch - Eur J Physiol. 466:2167–2176, 2014 (IF 3.654)
  6. Björling K, Morita H, Olsen MF, Prodan A, Hansen PB, Lory P, Holstein-Rathlou N-H and Jensen LJ. Myogenic tone is impaired at low arterial pressure in mice deficient in the low voltage-activated CaV3.1 T-type Ca2+ channel. Acta Physiol. (Oxford) 207, 709–720, 2013. (IF 4.066)
  7. Hald BO, Jacobsen JCB, Braunstein TH, Inoue R, Ito Y, Sørensen PG, Holstein-Rathlou N-H, & Jensen LJ. BKCa and KV channels limit conducted vasomotor responses in rat mesenteric terminal arterioles. Pflügers Arch – Eur J Physiol 463:279–295, 2012. (IF 3.654)
  8. Salomonsson M, Braunstein TH, Holstein-Rathlou N-H and Jensen LJ. Na+-independent, nifedipine-resistant rat afferent arteriolar Ca2+ responses to noradrenaline: possible role of TRPC channels. Acta Physiol (Oxford) 200(3):265-78, 2010 (IF 4.066)
  9. Ngo AT, Jensen LJ, Riemann M, Holstein-Rathlou N-H, Torp-Pedersen C. Oxygen sensing and conducted vasomotor responses in mouse cremaster arterioles in situ. Pflugers Arch 460(1):41-53, 2010 (IF 3.654)
  10. Inoue, R., *Jensen. LJ., Jian, Z., Shi, J., Hai, L., Lurie, AI., Henriksen, FH., Salomonsson, M., Morita, H., Kawarabayashi, Y., Mori, M., Mori, Y., Ito, Y. Synergistic activation of vascular TRPC6 channel by receptor and mechanical stimulation via PLC/diacylglycerol and PLA2/ω-hydroxylase/20-HETE pathways. Circulation Research 104:1399-1409, 2009. * Shared first-author (IF 11.551 – Level 2)