EXFIMO - Experimental Fish Models

Decoding innate immune signatures driving trained and adaptive immunity in fish using a high-resolution in vivo and in vitro zebrafish model
By utilizing an in vivo zebrafish model, we can decode the nature of the innate responses on a cellular level and predict the nature of trained and acquired protection.
SUMMARY AND AIM: Fish rely heavily on their innate immune system for protection against pathogens. Nevertheless, immunological protection can also be achieved through natural infections or vaccination. For a vaccine to induce durable adaptive protection, activation of innate immunity is required to initiate and shape immune memory.
Read more about this project here

How do migrating parasitic worms escape the perils of the host immune system? A 3D-omics resolution of host/parasite interactions
Parasitic worms penetrate host organisms and migrate through the body to their target destination without getting killed by the host immune system. This is an amazing task for a foreign organism big enough to be visible by the naked eye. Yet we have very limited knowledge about how the parasite manage the migration and the battle that goes on inside the host between parasite and immune system. We have a unique opportunity to optically 3D document host/parasite interactions real-time inside a living organism by studying worm infections in zebrafish. We will use transgenic lines of zebrafish which facilitate in vivo real-time imaging of host immunologically relevant defence mechanisms as well as worm penetration and immune evasive strategies. We will also elucidate immune evasive strategies of the parasite using proteomics and identify factors secreted to manipulate the host. This high-resolution 3D model will provide a platform to explain complicated host/parasite interactions.

STRØMPISTOLEN (GUDP): Udvikling af vandbehandlingsenhed til reduktion af patogen load i landbaseret akvakultur.

HURTIGFISK (GUDP)
Anvendelse af miljø-eNA-teknologi til ikke-invasiv og hurtig påvisning af fiskepatogener i dansk akvakultur on-site. Read the Press release 

RASOPTA (Horizon2020 ITN)
Safeguarding future production of fish in aquaculture systems with water recirculation.

ZEBRAFISH: The zebrafish as an experimental model

Aktivt slam og intelligent sygdomskontrol (Europæiske Hav- og Fiskeristyrelse (EHFF) 

Resistance genes (DFF)

Den Usynlige verden (KUs almene fond)

Co-projects 

• Ecoprawn (DANIDA)
• Profishience (GUDP)
• Epigenome Microbiome Interactions with GLOBE
• Linking host and parasite microbiomes to probe the nature of parasitism
• Zebrafish and CRISPR/CAS with GLOBE