Continuous-data diagnostic tests for paratuberculosis as a multistage disease
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Continuous-data diagnostic tests for paratuberculosis as a multistage disease. / Toft, Nils; Nielsen, Søren Saxmose; Jørgensen, Erik.
In: Journal of Dairy Science, Vol. 88, No. 11, 2005, p. 3923-3931.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Continuous-data diagnostic tests for paratuberculosis as a multistage disease
AU - Toft, Nils
AU - Nielsen, Søren Saxmose
AU - Jørgensen, Erik
PY - 2005
Y1 - 2005
N2 - We devised a general method for interpretation of multistage diseases using continuous-data diagnostic tests. As an example, we used paratuberculosis as a multistage infection with 2 stages of infection as well as a noninfected state. Using data from a Danish research project, a fecal culture testing scheme was linked to an indirect ELISA and adjusted for covariates (parity, age at first calving, and days in milk). We used the log-transformed optical densities in a Bayesian network to obtain the probabilities for each of the 3 infection stages for a given optical density (adjusted for covariates). The strength of this approach was that the uncertainty associated with a test was imposed directly on the individual test result rather than aggregated into the population-based measures of test properties (i.e., sensitivity and specificity)
AB - We devised a general method for interpretation of multistage diseases using continuous-data diagnostic tests. As an example, we used paratuberculosis as a multistage infection with 2 stages of infection as well as a noninfected state. Using data from a Danish research project, a fecal culture testing scheme was linked to an indirect ELISA and adjusted for covariates (parity, age at first calving, and days in milk). We used the log-transformed optical densities in a Bayesian network to obtain the probabilities for each of the 3 infection stages for a given optical density (adjusted for covariates). The strength of this approach was that the uncertainty associated with a test was imposed directly on the individual test result rather than aggregated into the population-based measures of test properties (i.e., sensitivity and specificity)
U2 - 10.3168/jds.S0022-0302(05)73078-2
DO - 10.3168/jds.S0022-0302(05)73078-2
M3 - Journal article
VL - 88
SP - 3923
EP - 3931
JO - Journal of Dairy Science
JF - Journal of Dairy Science
SN - 0022-0302
IS - 11
ER -
ID: 12211983