Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin
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Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin. / Gutman, N.; Hansen, Mie Johanne; Bertelsen, M. F.; Bojesen, A. M.
In: Letters in Applied Microbiology, Vol. 62, No. 3, 03.2016, p. 237-242.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Pasteurellaceae bacteria from the oral cavity of Tasmanian devils (Sarcophilus Harrisii) show high minimum inhibitory concentration values towards aminoglycosides and clindamycin
AU - Gutman, N.
AU - Hansen, Mie Johanne
AU - Bertelsen, M. F.
AU - Bojesen, A. M.
PY - 2016/3
Y1 - 2016/3
N2 - Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils’ biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.
AB - Threatened by Devil Facial Tumor Disease, the Tasmanian devil populations are vulnerable and decreasing. Additionally, the devils’ biting behaviour elevates their risk of acquiring bite wound infections caused by members of the bacterial Pasteurellaceae family that are natural inhabitants of the oral microbiota. In medical management of such bite wounds, antimicrobial susceptibility profiles are crucial. Prior to this investigation, no available data on minimal inhibitory concentration (MIC) values existed. A total of 26 isolates obtained from the oral cavity of 26 healthy Tasmanian devils were tested for their antimicrobial susceptibility by broth micro dilution. Most prominently, high MIC values for clindamycin (≥4 μg ml−1), gentamicin (≥8 μg ml−1) and amikacin (≥32 μg ml−1), were observed for 92, 77 and 73% of the strains tested respectively. This study may be used as a guideline for antimicrobial therapy against bite wound infections caused by Pasteurellaceae originating from the oral cavity of Tasmanian devils.
KW - antimicrobial susceptibility
KW - MIC
KW - minimum inhibitory concentration
KW - Pasteurellaceae
KW - Sarcophilus harrisii
KW - Tasmanian devil
U2 - 10.1111/lam.12545
DO - 10.1111/lam.12545
M3 - Journal article
C2 - 26744057
VL - 62
SP - 237
EP - 242
JO - Proceedings of the Society for Applied Bacteriology
JF - Proceedings of the Society for Applied Bacteriology
SN - 0266-8254
IS - 3
ER -
ID: 165577360