Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction? / Natterson-Horowitz, Barbara; Baccouche, Basil M; Mary, Jennifer; Shivkumar, Tejas; Bertelsen, Mads Frost; Aalkjær, Christian; Smerup, Morten H; Ajijola, Olujimi A; Hadaya, Joseph; Wang, Tobias.

In: Evolution, Medicine, and Public Health, Vol. 9, No. 1, 2021, p. 248-255.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Natterson-Horowitz, B, Baccouche, BM, Mary, J, Shivkumar, T, Bertelsen, MF, Aalkjær, C, Smerup, MH, Ajijola, OA, Hadaya, J & Wang, T 2021, 'Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction?', Evolution, Medicine, and Public Health, vol. 9, no. 1, pp. 248-255. https://doi.org/10.1093/emph/eoab016

APA

Natterson-Horowitz, B., Baccouche, B. M., Mary, J., Shivkumar, T., Bertelsen, M. F., Aalkjær, C., Smerup, M. H., Ajijola, O. A., Hadaya, J., & Wang, T. (2021). Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction? Evolution, Medicine, and Public Health, 9(1), 248-255. https://doi.org/10.1093/emph/eoab016

Vancouver

Natterson-Horowitz B, Baccouche BM, Mary J, Shivkumar T, Bertelsen MF, Aalkjær C et al. Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction? Evolution, Medicine, and Public Health. 2021;9(1):248-255. https://doi.org/10.1093/emph/eoab016

Author

Natterson-Horowitz, Barbara ; Baccouche, Basil M ; Mary, Jennifer ; Shivkumar, Tejas ; Bertelsen, Mads Frost ; Aalkjær, Christian ; Smerup, Morten H ; Ajijola, Olujimi A ; Hadaya, Joseph ; Wang, Tobias. / Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction?. In: Evolution, Medicine, and Public Health. 2021 ; Vol. 9, No. 1. pp. 248-255.

Bibtex

@article{40d38bc01dc84536924542d3677aa038,
title = "Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction?",
abstract = "The evolved adaptations of other species can be a source of insight for novel biomedical innovation. Limitations of traditional animal models for the study of some pathologies are fueling efforts to find new approaches to biomedical investigation. One emerging approach recognizes the evolved adaptations in other species as possible solutions to human pathology. The giraffe heart, for example, appears resistant to pathology related to heart failure with preserved ejection fraction (HFpEF)-a leading form of hypertension-associated cardiovascular disease in humans. Here, we postulate that the physiological pressure-induced left ventricular thickening in giraffes does not result in the pathological cardiovascular changes observed in humans with hypertension. The mechanisms underlying this cardiovascular adaptation to high blood pressure in the giraffe may be a bioinspired roadmap for preventive and therapeutic strategies for human HFpEF.",
author = "Barbara Natterson-Horowitz and Baccouche, {Basil M} and Jennifer Mary and Tejas Shivkumar and Bertelsen, {Mads Frost} and Christian Aalkj{\ae}r and Smerup, {Morten H} and Ajijola, {Olujimi A} and Joseph Hadaya and Tobias Wang",
note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.",
year = "2021",
doi = "10.1093/emph/eoab016",
language = "English",
volume = "9",
pages = "248--255",
journal = "Evolution, Medicine and Public Health",
issn = "2050-6201",
publisher = "Oxford University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Did giraffe cardiovascular evolution solve the problem of heart failure with preserved ejection fraction?

AU - Natterson-Horowitz, Barbara

AU - Baccouche, Basil M

AU - Mary, Jennifer

AU - Shivkumar, Tejas

AU - Bertelsen, Mads Frost

AU - Aalkjær, Christian

AU - Smerup, Morten H

AU - Ajijola, Olujimi A

AU - Hadaya, Joseph

AU - Wang, Tobias

N1 - © The Author(s) 2021. Published by Oxford University Press on behalf of the Foundation for Evolution, Medicine, and Public Health.

PY - 2021

Y1 - 2021

N2 - The evolved adaptations of other species can be a source of insight for novel biomedical innovation. Limitations of traditional animal models for the study of some pathologies are fueling efforts to find new approaches to biomedical investigation. One emerging approach recognizes the evolved adaptations in other species as possible solutions to human pathology. The giraffe heart, for example, appears resistant to pathology related to heart failure with preserved ejection fraction (HFpEF)-a leading form of hypertension-associated cardiovascular disease in humans. Here, we postulate that the physiological pressure-induced left ventricular thickening in giraffes does not result in the pathological cardiovascular changes observed in humans with hypertension. The mechanisms underlying this cardiovascular adaptation to high blood pressure in the giraffe may be a bioinspired roadmap for preventive and therapeutic strategies for human HFpEF.

AB - The evolved adaptations of other species can be a source of insight for novel biomedical innovation. Limitations of traditional animal models for the study of some pathologies are fueling efforts to find new approaches to biomedical investigation. One emerging approach recognizes the evolved adaptations in other species as possible solutions to human pathology. The giraffe heart, for example, appears resistant to pathology related to heart failure with preserved ejection fraction (HFpEF)-a leading form of hypertension-associated cardiovascular disease in humans. Here, we postulate that the physiological pressure-induced left ventricular thickening in giraffes does not result in the pathological cardiovascular changes observed in humans with hypertension. The mechanisms underlying this cardiovascular adaptation to high blood pressure in the giraffe may be a bioinspired roadmap for preventive and therapeutic strategies for human HFpEF.

U2 - 10.1093/emph/eoab016

DO - 10.1093/emph/eoab016

M3 - Journal article

C2 - 34447575

VL - 9

SP - 248

EP - 255

JO - Evolution, Medicine and Public Health

JF - Evolution, Medicine and Public Health

SN - 2050-6201

IS - 1

ER -

ID: 282946883