Molecular epidemiology of Porcine Parvovirus Type 1 (PPV1) and the reactivity of vaccine-induced antisera against historical and current PPV1 strains
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Molecular epidemiology of Porcine Parvovirus Type 1 (PPV1) and the reactivity of vaccine-induced antisera against historical and current PPV1 strains. / Vereecke, Nick; Kvisgaard, Lise Kirstine; Baele, Guy; Boone, Carine; Kunze, Marius; Larsen, Lars Erik; Theuns, Sebastiaan; Nauwynck, Hans.
In: Virus Evolution, Vol. 8, No. 1, veac053, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Molecular epidemiology of Porcine Parvovirus Type 1 (PPV1) and the reactivity of vaccine-induced antisera against historical and current PPV1 strains
AU - Vereecke, Nick
AU - Kvisgaard, Lise Kirstine
AU - Baele, Guy
AU - Boone, Carine
AU - Kunze, Marius
AU - Larsen, Lars Erik
AU - Theuns, Sebastiaan
AU - Nauwynck, Hans
N1 - Publisher Copyright: © Parvo, Eryseng
PY - 2022
Y1 - 2022
N2 - Porcine Parvovirus Type 1 (PPV1) contributes to important losses in the swine industry worldwide. During a PPV1 infection, embryos and fetuses are targeted, resulting in stillbirth, mummification, embryonic death, and infertility (SMEDI syndrome). Even though vaccination is common in gilts and sows, strains mainly belonging to the 27a-like group have been spreading in Europe since early 2000s, resulting in SMEDI problems and requiring in-depth studies into the molecular epidemiology and vaccination efficacy of commercial vaccines. Here, we show that PPV1 has evolved since 1855 [1737, 1933] at a rate of 4.71 × 10-5 nucleotide substitutions per site per year. Extensive sequencing allowed evaluating and reassessing the current PPV1 VP1-based classifications, providing evidence for the existence of four relevant phylogenetic groups. While most European strains belong to the PPV1a (G1) or PPV1b (G2 or 27a-like) group, most Asian and American G2 strains and some European strains were divided into virulent PPV1c (e.g. NADL-8) and attenuated PPV1d (e.g. NADL-2) groups. The increase in the swine population, vaccination degree, and health management (vaccination and biosafety) influenced the spread of PPV1. The reactivity of anti-PPV1 antibodies from sows vaccinated with Porcilis
AB - Porcine Parvovirus Type 1 (PPV1) contributes to important losses in the swine industry worldwide. During a PPV1 infection, embryos and fetuses are targeted, resulting in stillbirth, mummification, embryonic death, and infertility (SMEDI syndrome). Even though vaccination is common in gilts and sows, strains mainly belonging to the 27a-like group have been spreading in Europe since early 2000s, resulting in SMEDI problems and requiring in-depth studies into the molecular epidemiology and vaccination efficacy of commercial vaccines. Here, we show that PPV1 has evolved since 1855 [1737, 1933] at a rate of 4.71 × 10-5 nucleotide substitutions per site per year. Extensive sequencing allowed evaluating and reassessing the current PPV1 VP1-based classifications, providing evidence for the existence of four relevant phylogenetic groups. While most European strains belong to the PPV1a (G1) or PPV1b (G2 or 27a-like) group, most Asian and American G2 strains and some European strains were divided into virulent PPV1c (e.g. NADL-8) and attenuated PPV1d (e.g. NADL-2) groups. The increase in the swine population, vaccination degree, and health management (vaccination and biosafety) influenced the spread of PPV1. The reactivity of anti-PPV1 antibodies from sows vaccinated with Porcilis
KW - BEAST
KW - evolution
KW - molecular phylodynamics
KW - vaccination
KW - viral classification
U2 - 10.1093/ve/veac053
DO - 10.1093/ve/veac053
M3 - Journal article
C2 - 35815310
AN - SCOPUS:85134368586
VL - 8
JO - Virus Evolution
JF - Virus Evolution
SN - 2057-1577
IS - 1
M1 - veac053
ER -
ID: 317100504