Dorte Frees

Dorte Frees

Associate Professor

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    1. Published

      Salmonella isolates with different behavior in adhesion to surfaces studied by DNA micro array assisted analysis

      Holmstrøm, K., Olsen, K. N., Meldgaard, H., Bagge-Ravn, D., Frees, Dorte, Lauritsen, D., Gram, L. & Olsen, John Elmerdahl, 2005. 1 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    2. Published

      Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision

      Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, Dorte, 2019, In: Scientific Reports. 9, 11 p., 16456.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes

      Mellergaard, M., Høgh, R. I., Feilberg, Astrid Lund, Aldana, Blanca, Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, Stine Dam, Hansen, Camilla Hartmann Friis, Andresen, Lars, Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, Helle S., Frees, Dorte & Skov, Søren, 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology

      Xu, Lijuan, Henriksen, C., Mebus, Viktor Hundtofte, Guérillot, R., Petersen, A., Jacques, N., Jiang, J. H., Derks, R. J. E., Sánchez-López, E., Giera, M., Leeten, K., Stinear, T. P., Oury, C., Howden, B. P., Peleg, A. Y. & Frees, Dorte, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6, 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec

      Schelin, J., Cohn, M. T., Frisk, B. & Frees, Dorte, 2020, In: Toxins. 12, 9, 553.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA

      Bæk, K. T., Jensen, C., Farha, M. A., Nielsen, T. K., Paknejadi, E., Mebus, Viktor Hundtofte, Vestergaard, M., Brown, E. D. & Frees, Dorte, 2021, In: Frontiers in Molecular Biosciences. 8, 691569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A hitherto not recognized phenotype of spvA in Salmonella

      Frees, Dorte, Gram, L., Holmstrøm, K. & Olsen, John Elmerdahl, 2010, Proceedings: 13S international symposium salmonella and salmonellosis. p. 33-34 2 p.

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

    8. Published

      A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study

      Jensen, Louise Kruse, Frees, Dorte, Aalbæk, Bent, Koch, J., Iburg, T. M., Nielsen, O. L., Leifsson, Páll S. & Jensen, Henrik Elvang, 2011, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. 119, 2, p. 111-118 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      A porcine model of heamatogenous osteomyelitis: pathogenesis and pathology

      Jensen, Louise Kruse, Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Buelund, Lene Elisabeth, Svalastoga, Eiliv Lars & Jensen, Henrik Elvang, 2012. 1 p.

      Research output: Contribution to conference › Poster › Research

    10. Published

      A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study

      Nielsen, O. L., Mellergaard, M., Frees, Dorte, Larsen, M. N., Skov, Søren, Olsen, Lisbeth Høier & Reimann, Maria Josefine, 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A porcine subcutaneous Staphylococcus aureus abscess model - a pilot study

      Nielsen, O. L., Larsen, M. N., Frees, Dorte, Pedersen, M. M., Skov, Søren & Olsen, Lisbeth Høier, 2017.

      Research output: Contribution to conference › Conference abstract for conference › Communication

    12. Published

      Alternative roles of CIpX and CIpP in Staphylococus aureus stress toelrance and virulence.

      Frees, Dorte, Saara, N. A. Q., Philip, J. H. & Ingmer, Hanne, 2003, In: Molecular Microbiology. (2003) 48 (6), p. 1565 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Antibiotic Resistance and the MRSA Problem

      Vestergaard, M., Frees, Dorte & Ingmer, Hanne, 2019, In: Microbiology Spectrum. 7, 2, 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus

      Paulander, W. E. A., Varming, A. N., Bæk, K. T., Haaber, J. K., Frees, Dorte & Ingmer, Hanne, 2012, In: mBio. 3, 6, p. e00459-12 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri

      Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte, Dalsgaard, I. & Jørgensen, Louise von Gersdorff, 12 Jul 2016, In: P L o S One. 11, 7, e0158968.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Antigen uptake in zebrafish

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research

    17. Published

      Antigen uptake in zebrafish (Danio rerio)

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Poster › Research

    18. Published

      Antigen uptake in zebrafish (Danio rerio)

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research

    19. Published

      Antigen uptake in zebrafish (Danio rerio) at different life stages

      Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Jørgensen, Louise von Gersdorff, 2016.

      Research output: Contribution to conference › Conference abstract for conference › Research

    20. Published

      Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

      Baldry, M., Nakamura, Y., Nakagawa, S., Frees, Dorte, Matsue, H., Nunez, G. & Ingmer, Hanne, 2018, In: Journal of Infectious Diseases. 218, 6, p. 1009-1013

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Bacterial proteases and virulence

      Frees, Dorte, Brøndsted, Lone & Ingmer, Hanne, 2013, Regulated proteolysis in microorganisms. Dougan, D. A. (ed.). Springer, p. 161-192 32 p. (Subcellular biochemistry, Vol. 66).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    22. Published

      Cefoxitin treatment of MRSA leads to a shift in the IL-12/IL-23 production pattern in dendritic cells by a mechanism involving changes in the MAPK signaling

      Eld, H. M. S., Nielsen, E. M., Johnsen, Peter Riber, Marengo, M., Kamper, I. W., Frederiksen, L., Bonomi, F., Frees, Dorte, Iametti, S. & Frøkiær, Hanne, 2021, In: Molecular Immunology. 134, p. 1-12 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor

      Mellergaard, M., Skovbakke, S. L., Jepsen, S. D., Panagiotopoulou, N., Hansen, A. B. R., Tian, W., Lund, A., Høgh, R. I., Møller, S. H., Guérillot, R., Hayes, A. S., Erikstrup, L. T., Andresen, L., Peleg, A. Y., Larsen, A. R., Stinear, T. P., Handberg, A., Erikstrup, C., Howden, B. P., Goletz, S. & 2 others, Frees, Dorte & Skov, Søren, 2023, In: mBio. 14, 5, 21 p., e01349-23.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria

      Frees, Dorte, Savijoki, K., Varmanen, P. & Ingmer, Hanne, 2007, In: Molecular Microbiology. 63, 5, p. 1285-1295 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus

      Frees, Dorte, Chastanet, A., Quzi, S., Sørensen, K., Hill, P., Msadek, T. & Ingmer, Hanne, 2004, In: Molecular Microbiology. 54, 5, p. 1445-1462 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

      Frees, Dorte, Gerth, U. & Ingmer, Hanne, 2014, In: International Journal of Medical Microbiology. 304, 2, p. 142-149 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Clp-dependent proteolysis of the LexA N-terminal domain in Staphylococcus aureus

      Cohn, M. T., Kjelgaard, P. M., Frees, Dorte, Penadés, J. R. & Ingmer, Hanne, 2011, In: Microbiology. 157, 3, p. 677-684 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      ClpP participaytes in the degradation of misfolded protein in Lactococcuss lactis

      Frees, Dorte & Ingmer, Hanne, 1999, In: Molecular Microbiology. 31, 1, p. 79 - 87 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

      Larsen, J., Clasen, J., Hansen, J. E., Paulander, W., Petersen, A., Larsen, A. R. & Frees, Dorte, Jul 2016, In: Antimicrobial Agents and Chemotherapy. 60, 7, p. 4401-4403

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Distribution, expression and secretion of the RTX-toxin GtxA among members of the genus Gallibacterium

      Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2010, Pathogenesis of bacterial diseases in animals. p. 22 1 p.

      Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research

    31. Published

      Expression and secretion of the RTX-toxin GtxA among members of the genus Gallibacterium

      Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2011, In: Veterinary Microbiology. 153, 1-2, p. 116-123 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Finding New Fundamental Pieces for the Bacterial Cell Division Puzzle

      Frees, Dorte & Ingmer, Hanne, 2022, In: mBio. 13, 4, e0073722.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Fødevaresikkerhed i udvikling

      Ingmer, Hanne, Larsen, M. H., Leisner, Jørgen, Frees, Dorte, Brøndsted, Lone & Dalsgaard, Anders, 2019, In: Dansk Veterinaertidsskrift. 2019, 7, p. 10-13

      Research output: Contribution to journal › Journal article › Communication

    34. Published

      Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing

      Bæk, K. T., Frees, Dorte, Renzoni, A., Barras, C., Rodriguez, N., Manzano, C. & Kelley, W. L., 2013, In: P L o S One. 8, 9, 16 p., e77122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network

      Frees, Dorte, Sørensen, K. & Ingmer, Hanne, 2005, In: Infection and Immunity. 73, 12, p. 8100-8108 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus

      Jelsbak, L., Hemmingsen, L., Donat, S., Ohlsen, K., Boye, K., Westh, H., Ingmer, Hanne & Frees, Dorte, 2010, In: International Journal of Medical Microbiology. 300, 4, p. 229-236 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation

      Kristensen, B. M., Frees, Dorte & Bojesen, Anders Miki, 2010, In: Veterinary Research. 41, 25, 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP

      Savijoki, K., Ingmer, Hanne, Frees, Dorte, Vogensen, Finn Kvist, Palva, A. & Varmanen, P., 2003, In: Molecular Microbiology. 50, 2, p. s.609-621 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Identification of proteins induced at low pH in Lactococcus lactis

      Frees, Dorte, Vogensen, Finn Kvist & Ingmer, Hanne, 2003, In: International Journal of Food Microbiology. 87, 87, p. 293-300 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Identification of the ClpX Regulon in Staphylococcus aureus

      Jelsbak, L., Thomsen, Line Elnif, Ingmer, Hanne, Donat, S., Ohlsen, K. & Frees, Dorte, 2006. 1 p.

      Research output: Contribution to conference › Poster › Research

    41. Published

      Inactivation of a gene that is highly conserved in Gram-positive bacteria stimulates degradation of non-native proteins and concomitantly increases stress tolerance in Lactococcus lactis

      Frees, Dorte, Varmanen, P. & Ingmer, Hanne, 2001, In: Molecular Microbiology. 41, 1, p. 93-103 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Investigation of correlation between gene expressions of 162 selected genes and survival and colonization abilities of Salmonella strains in the food chain

      Olsen, John Elmerdahl, Gram, L., Frees, Dorte & Holmstrøm, K., 2008, The 21st International ICFMH Symposium "Evolving Microbial Food Quality and Safety": Programme and Abstract Book. p. 164 1 p.

      Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research

    43. Published

      Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool

      Olsen, John Elmerdahl, Frees, Dorte, Kyvsgaard, N. C. & Barco, L., 2024, In: Letters in Applied Microbiology. 77, 2, 9 p., ovae015.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis

      Jensen, Louise Kruse, Iburg, T. M., Nielsen, O. L., Leifsson, Páll S., Dahl-Pedersen, Kirstin, Koch, J., Frees, Dorte, Aalbæk, Bent, Heegaard, P. M. H. & Jensen, Henrik Elvang, 2012, In: Prostaglandins & Other Lipid Mediators. 97, 3-4, p. 103-108 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Method for screening compounds that influence virulence gene expression in Staphylococcus aureus

      Nielsen, A., Nielsen, K. F., Frees, Dorte, Larsen, T. O. & Ingmer, Hanne, 2010, In: Antimicrobial Agents and Chemotherapy. 54, 1, p. 509-512 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564

      Frees, Dorte, Andersen, J. H., Hemmingsen, L., Koskenniemi, K., Bæk, K. T., Muhammed, Musemma Kedir, Gudeta, D. D., Nyman, T. A., Sukura, A., Varmanen, P. & Savijoki, K., 2012, In: Journal of Proteome Research. 11, 1, p. 95-108 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus

      Jensen, C., Li, H., Vestergaard, M., Dalsgaard, Anders, Frees, Dorte & Leisner, Jørgen, 2020, In: Frontiers in Microbiology. 11, 8 p., 1007.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

      Baldry, M., Nielsen, A., Bojer, Martin Saxtorph, Zhao, Y., Friberg, C., Ifrah, D., Heede, N. G., Larsen, T. O., Frøkiær, Hanne, Frees, Dorte, Zhang, L., Dai, H. & Ingmer, Hanne, 22 Dec 2016, In: PLOS ONE. 11, 12, 16 p., e0168305.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Norlichexanthone modulate Staphylococcus aureus virulence gene expression possibly via agr and sae

      Nielsen, A., Ifrah, D., Friberg, C., Larsen, T. O., Novick, R. P., Frøkiær, Hanne, Frees, Dorte, Hede, N. G. & Ingmer, Hanne, 2012.

      Research output: Contribution to conference › Poster › Research

    50. Published

      Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis

      Johansen, L. K., Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Iburg, T. M., Svalastoga, Eiliv Lars, Buelund, Lene Elisabeth, Bjarnsholt, Thomas, Høiby, Niels & Jensen, Henrik Elvang, 2012, In: Journal of Comparative Pathology. 147, 2-3, p. 343-353 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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