Kristine Freude

Kristine Freude

Professor


  1. Published
  2. Published

    Genetic protection modifications: Moving beyond the binary distinction between therapy and enhancement for human genome editing

    Mikkelsen, R. C. B., Frederiksen, Henriette Reventlow S, Gjerris, Mickey, Holst, B., Hyttel, P., Luo, Y., Freude, Kristine & Sandøe, Peter, 2019, In: CRISPR Journal. 2, 6, p. 362-369 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets

    Garcia Bermudez, Mariana Yolotzin, Freude, Kristine, Mouhammad, Zaynab Ahmad, van Wijngaarden, P., Martin, K. K. & Kolko, Miriam, 2021, In: Frontiers in Neurology. 12, 17 p., 624983.

    Research output: Contribution to journalReviewResearchpeer-review

  4. Published

    Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia

    Aldana, Blanca, Zhang, Y., Jensen, P., Chandrasekaran, Abinaya, Christensen, S. K., Nielsen, T. T., Nielsen, Jørgen Erik, Hyttel, P., Larsen, M. R., Waagepetersen, Helle S. & Freude, Kristine, 2020, In: Molecular Brain. 13, 1, 7 p., 125.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Golgi fragmentation: One of the earliest organelle phenotypes in Alzheimer's disease neurons

    Haukedal, H., Corsi, G. I., Gadekar, V. P., Doncheva, N. T., Kedia, S., de Haan, N., Chandrasekaran, A., Jensen, P., Schiønning, P., Vallin, S., Marlet, F. R., Poon, A., Pires, C., Agha, F. K., Wandall, H. H., Cirera, S., Simonsen, A. H., Nielsen, T. T., Nielsen, J. E., Hyttel, P. & 7 others, Muddashetty, R., Aldana, Blanca, Gorodkin, Jan, Nair, D., Meyer, M., Larsen, M. R. & Freude, Kristine, 2023, In: Frontiers in Neuroscience. 17, 17 p., 1120086.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease

    Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Human Induced Pluripotent stem cells and their derivatives for disease modeling and therapeutic applications in Alzheimer's disease

    Pires, C., Hall, Vanessa Jane & Freude, Kristine, 20 May 2016, Alzheimer's disease. SMGroup, p. 1-25 25 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  8. Published

    Human induced pluripotent cells in personalized treatment of monogenic epilepsies

    Mohammad, N. A., Freude, Kristine, Haukedal, H., Tümer, Asuman Zeynep & Møller, R. S., 2020, In: Journal of Translational Genetics and Genomics. 2020, 4, p. 238-250

    Research output: Contribution to journalReviewResearchpeer-review

  9. Published

    Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts

    Li, D., Secher, Jan Bojsen-Møller, Juhl, M., Mashayekhi-Nezamabadi, K., Nielsen, T. T., Holst, B., Hyttel, P., Freude, Kristine & Hall, Vanessa Jane, 2017, In: Cell Cycle. 16, 11, p. 1070-1084

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Identification of potential biomarkers in donor cows for in vitro embryo production by granulosa cell transcriptomics

    Mazzoni, G., Salleh, S. M., Freude, Kristine, Pedersen, H. S., Stroebech, L., Callesen, H., Hyttel, P. & Kadarmideen, H. N., 2017, In: PLOS ONE. 12, 4, 27 p., e0175464.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Implications of Glycosylation in Alzheimer’s Disease

    Haukedal, H. & Freude, Kristine, 2021, In: Frontiers in Neuroscience. 14, 18 p., 625348.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    Haukedal, H. & Freude, Kristine, 2019, In: Journal of Molecular Biology. 431, 9, p. 1818-1829

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Implications of SNP-triggered miRNA dysregulation in Schizophrenia development

    Mohamed, Fadumo Abdullahi & Freude, Kristine, 26 Jan 2024, In: Frontiers in Genetics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    In vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence

    Mazzoni, G., Razza, E., Pedersen, H. S., Secher, Jan Bojsen-Møller, Kadarmideen, H. N., Callesen, H., Stroebech, L., Freude, Kristine & Hyttel, P., 2017, In: Animal Reproduction. 14, 3, p. 482-489 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. E-pub ahead of print

    Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease

    Salcedo, C., Pozo Garcia, V., Garcia-Adan, B., Ameen, Aisha, Gegelashvili, G., Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2024, (E-pub ahead of print) In: Journal of Neurochemistry.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Induced pluripotent stem cells derived from Alzheimer's disease patients: the promise, the hope and the path ahead

    Freude, Kristine, Pires, C., Hyttel, P. & Hall, Vanessa Jane, 2014, In: Journal of Clinical Medicine. 3, 4, p. 1402-1436 35 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

    Pessôa, L. V. D. F., Bressan, F. F. & Freude, Kristine, 2019, In: World Journal of Stem Cells. 11, 8, p. 491-505 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    Inflammatory Responses and Sex Differences of Patient Derived Cell Models of Microglia in Alzheimer's Disease

    Haukedal, H., Thomassen, F., Kadlecová, Marion & Freude, Kristine, 20 May 2024.

    Research output: Contribution to conferencePosterCommunication

  19. Published

    Initial embryology and pluripotent stem cells in the pig: the quest for establishing the pig as a model for cell therapy

    Secher, Jan Bojsen-Møller, Callesen, H., Freude, Kristine & Hyttel, P., 1 Jan 2016, In: Theriogenology. 85, 1, p. 162-171 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state

    Bernardo, A. S., Jouneau, A., Marks, H., Kensche, P., Kobolak, J., Freude, K., Hall, V., Feher, A., Polgar, Z., Sartori, C., Bock, I., Louet, C., Faial, T., Kerstens, H. H. D., Bouissou, C., Parsonage, G., Mashayekhi, K., Smith, J. C., Lazzari, G., Hyttel, P. & 4 others, Stunnenberg, H. G., Huynen, M., Pedersen, R. A. & Dinnyes, A., 2018, In: Biology Open. 7, 8, 17 p., bio033282.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Metabolic impairments in neurons and astrocytes derived from human induced pluripotent stem cells of Alzheimer's disease patients

    Garcia, B. A., Salcedo, C., Hyttel, P., Waagepetersen, Helle S. & Freude, Kristine, 2019, p. 111-111.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  22. Published

    Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells

    Schmidt, S. I., Bogetofte, H., Ritter, L., Agergaard, Jette Bach, Hammerich, D., Kabiljagic, A. A., Wlodarczyk, A., Lopez, S. G., Sørensen, M. D., Jørgensen, M. L., Okarmus, J., Serrano, A. M., Kristensen, Bjarne Winther, Freude, Kristine, Owens, T. & Meyer, M., 2021, In: Stem Cell Reports. 16, p. 1-14

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency

    Yan, Z., Al-Saaidi, R. A., Fernandez Guerra, P., Freude, Kristine, Olsen, R. K. J., Jensen, U. B., Gregersen, N., Hyttel, P., Bolund, L., Aagaard, L., Bross, P. & Luo, Y., 2017, In: Stem Cells and Development. 26, 3, p. 166-176

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges

    Poon, A., Zhang, Y., Chandrasekaran, Abinaya, Phanthong, P., Schmid, B., Nielsen, T. T. & Freude, Kristine, 2017, In: New Biotechnology. 39, Part B, p. 190-198

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells

    Kobolák, J., Molnár, K., Varga, E., Bock, I., Jezsó, B., Téglási, A., Zhou, S., Lo Giudice, M., Hoogeveen-Westerveld, M., Pijnappel, W. P., Phanthong, P., Varga, N., Kitiyanant, N., Freude, Kristine, Nakanishi, H., László, L., Hyttel, P. & Dinnyés, A., 2019, In: Experimental Cell Research. 380, 2, p. 216-233 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Muller cell survival and function is maintained by the presence of lactate

    Vohra, Rupali, Skytt, D. M., Aldana, Blanca, Freude, Kristine, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, Jul 2018, p. 1480. 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  27. Published

    Mutation in FTD3 CHMP2B causes impaired autography and distorted energy metabolism cumulating in reactive astrocyte phenotypes

    Chandrasekaran, A., Dittlau, K. S., Corsi, G., Haukedal, H., Doncheva, N. T., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J., Kolko, M., Kobolak, J., Dinnyes, A., Hyttel, P., Palakodeti, D., Gorodkin, J. & 4 others, Muddashetty, R., Meyer, M., Aldana, Blanca & Freude, Kristine, 2020.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  28. Published

    Mutations in FTD3 CHMP2B causes impaired autophagy and distorted energy metabolism cumulating in reactive astrocyte phenotypes

    Chandrasekaran, A., Dittlau, K. S., Corsi, G., Doncheva, N. T., Haukedal, H., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J., Kolko, M., Kobolak, J., Dinnyes, A., Hyttel, P., Palakodeti, D., Gorodkin, J. & 4 others, Muddashetty, R., Meyer, M., Aldana, Blanca & Freude, Kristine, 2020.

    Research output: Contribution to conferencePosterResearch

  29. Published

    Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation

    Freude, K., Hoffmann, K., Jensen, L., Delatycki, M. B., des Portes, V., Moser, B., Hamel, B., van Bokhoven, H., Moraine, C., Fryns, J., Chelly, J., Gécz, J., Lenzner, S., Kalscheuer, V. M., Ropers, H. & Freude, Kristine, Aug 2004, In: American Journal of Human Genetics. 75, 2, p. 305-9 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation

    Kalscheuer, V. M., Freude, K., Musante, L., Jensen, L. R., Yntema, H. G., Gécz, J., Sefiani, A., Hoffmann, K., Moser, B., Haas, S., Gurok, U., Haesler, S., Aranda, B., Nshedjan, A., Tzschach, A., Hartmann, N., Roloff, T-C., Shoichet, S., Hagens, O., Tao, J. & 14 others, Van Bokhoven, H., Turner, G., Chelly, J., Moraine, C., Fryns, J., Nuber, U., Hoeltzenbein, M., Scharff, C., Scherthan, H., Lenzner, S., Hamel, B. C. J., Schweiger, S., Ropers, H. & Freude, Kristine, Dec 2003, In: Nature Genetics. 35, 4, p. 313-5 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog

    Chandrasekaran, Abinaya, Thomsen, B. B., Agerholm, Jørgen Steen, Pessôa, L. V. D. F., Godoy Pieri, N. C., Sabaghidarmiyan, V., Langley, K., Kolko, Miriam, De Andrade, A. F. C., Bressan, F. F., Hyttel, P., Berendt, Mette & Freude, Kristine, 2021, In: Frontiers in Veterinary Science. 8, 14 p., 725386.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Neuronal alpha-amylase is important for neuronal activity and glycogenolysis and reduces in presence of amyloid beta pathology

    Byman, E., Martinsson, I., Haukedal, H., Gouras, G., Freude, Kristine, Wennstrom, M. & Netherlands Brain Ban, N. B. B., 2021, In: Aging Cell. 20, 8, 14 p., 13433.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

    Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, Abinaya, Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., Nielsen, Jørgen Erik, Holst, B., Freude, Kristine, Hyttel, P., Kobolák, J. & Dinnyés, A., Dec 2017, In: Alzheimer's Research and Therapy. 9, 1, 19 p., 90.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Neurosphere based differentiation of human iPSC improves astrocyte differentiation

    Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera, Susanna, Hyttel, P., Dinnyés, A., Freude, Kristine & Avci, H. X., 2016, In: Stem Cells International. 2016, 15 p., 4937689.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

    Duque Villegas, Luisana Carolina, Nørremølle, Anne, Freude, Kristine & Vilhardt, Frederik, 2021, In: Frontiers in Aging Neuroscience. 13, 20 p., 736734.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors

    Schaffer, A. E., Freude, Kristine, Nelson, S. B. & Sander, M., 2010, In: Developmental Cell. 18, 6, p. 1022-1029 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

    Prakash, N., Puelles, E., Freude, Kristine, Trümbach, D., Omodei, D., Di Salvio, M., Sussel, L., Ericson, J., Sander, M., Simeone, A. & Wurst, W., 2009, In: Development (Cambridge, England). 136, 15, p. 2545-2555 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders

    Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published
  40. Published

    Oocytes, embryos and pluripotent stem cells from a biomedical perspective

    Hyttel, P., Pessôa, L. V. D. F., Secher, Jan Bojsen-Møller, Dittlau, Katarina Stoklund, Freude, Kristine, Hall, Vanessa Jane, Fair, T., Assey, R. J., Laurincik, J., Callesen, H., Greve, T. & Stroebech, L. B., 2019, In: Animal Reproduction. 16, 3, p. 508-523 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Optimization of three-dimensional imaging on in vitro produced porcine blastocysts and chimeras for stem cell testing: a technology report.

    Secher, Jan Bojsen-Møller, Freude, Kristine, Li, R. & Callesen, H., 2015, In: Stem Cells and Development. 24, 9, p. 1141-1145 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Oxidative stress in optic neuropathies

    Sanz-Morello, B., Ahmadi, H., Vohra, Rupali, Saruhanian, S., Freude, Kristine, Hamann, Steffen & Kolko, Miriam, 2021, In: Antioxidants. 10, 10, 27 p., 1538.

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1

    Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, Oct 2020.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  44. Published

    Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1

    Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, 26 Mar 2019.

    Research output: Contribution to conferencePosterCommunication

  45. Published

    Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B

    Zhang, Y., Schmid, B., Qas Younan, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA. & 4 others, Holst, B., Clausen, C., Hyttel, P. & Freude, Kristine, 2017, In: Stem Cell Reports. 8, 3, p. 648-658

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Potential Retinal Biomarkers in Alzheimer's Disease

    Garcia Bermudez, Mariana Yolotzin, Vohra, Rupali, Freude, Kristine, van Wijngaarden, P., Martin, K. K., Thomsen, M. S., Aldana, Blanca & Kolko, Miriam, 2023, In: International Journal of Molecular Sciences (Online). 24, 21, 26 p., 15834.

    Research output: Contribution to journalReviewResearchpeer-review

  47. Published

    Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants

    Vohra, Rupali, Sanz-Morello, B., Tams, A. L. M., Mouhammad, Zaynab Ahmad, Freude, Kristine, Hannibal, Jens, Aldana, Blanca, Bergersen, L. H. & Kolko, Miriam, 2022, In: Cells. 11, 13, 2098.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts

    Xiong, K., Zhou, Y., Blichfeld, K. A., Hyttel, P., Bolund, L., Freude, Kristine & Luo, Y., Jun 2017, In: Cellular Reprogramming. 19, 3, p. 189-198 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    RhoA Signaling in Neurodegenerative Diseases

    Schmidt, S. I., Blaabjerg, M., Freude, Kristine & Meyer, M., 2022, In: Cells. 11, 9, 1520.

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Role of S1P and RhoA/Rho-kinase pathways in age-related myogenic tone deficiency in mouse small mesenteric and cerebral arteries

    Skovsted, G. F., Aupetit, A., Björling , K., Haanes, K. A., Syberg, S., Jørgensen, N. R., Aldana, Blanca, Freude, Kristine, Pearson, J. T. & Jensen, Lars Jørn, 2 Jul 2024.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

ID: 38189431