Kristine Freude
Professor
Pathobiological Sciences
Grønnegårdsvej 7, 1870 Frederiksberg C
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Implications of SNP-triggered miRNA dysregulation in Schizophrenia development
Mohamed, Fadumo Abdullahi & Freude, Kristine, 26 Jan 2024, In: Frontiers in Genetics.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic protection modifications: Moving beyond the binary distinction between therapy and enhancement for human genome editing
Mikkelsen, R. C. B., Frederiksen, Henriette Reventlow S, Gjerris, Mickey, Holst, B., Hyttel, P., Luo, Y., Freude, Kristine & Sandøe, Peter, 2019, In: CRISPR Journal. 2, 6, p. 362-369 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Co-expression network analysis to identify pluripotency biomarkers in bovine and porcine embryos
Mazzoni, G., Freude, Kristine, Hall, Vanessa Jane, Mashayekhi-Nezamabadi, K., Hyttel, P., Dinnyés, A. & Kadarmideen, H., 2015. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Identification of potential biomarkers in donor cows for in vitro embryo production by granulosa cell transcriptomics
Mazzoni, G., Salleh, S. M., Freude, Kristine, Pedersen, H. S., Stroebech, L., Callesen, H., Hyttel, P. & Kadarmideen, H. N., 2017, In: PLOS ONE. 12, 4, 27 p., e0175464.Research output: Contribution to journal › Journal article › Research › peer-review
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In vitro production of bovine embryos: Cumulus/granulosa cell gene expression patterns point to early atresia as beneficial for oocyte competence
Mazzoni, G., Razza, E., Pedersen, H. S., Secher, Jan Bojsen-Møller, Kadarmideen, H. N., Callesen, H., Stroebech, L., Freude, Kristine & Hyttel, P., 2017, In: Animal Reproduction. 14, 3, p. 482-489 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems Biology and Stem Cell Pluripotency: Revisiting the Discovery of Induced Pluripotent Stem Cell
Mashayekhi, K., Hall, Vanessa Jane, Freude, Kristine, Høffding, M. K., Labusca, L. & Hyttel, P., 29 Oct 2016, Systems Biology in Animal Production and Health. Kadarmideen, H. N. (ed.). 1 ed. Springer, Vol. 2. p. 127-154 28 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The Nav1.5 variant G213D found in patients with MEPPC is associated with increased window current and gating pore current
Magnusson, H. B. D., Geryk, M., Cordeiro, J. M., Lind, J. U., Jensen, H. K., Freude, Kristine & Callø, Kirstine, 16 Sep 2023.Research output: Contribution to conference › Poster › Communication
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Generation of neural progenitor cells (NPC) from porcine induced pluripotent stem cells (piPSC)
Machado, L. S., Pieri, N. C. G., Botigelli, R. C., de Castro, R. V. G., de Souza, A. F., Bridi, A., Lima, M. A., Fantinato Neto, P., de Figueiredo Pessôa, L. V., Martins, S. M. M. K., de Andrade, A. F. C., Freude, Kristine & Bressan, F. F., 2020, In: Journal of Tissue Engineering and Regenerative Medicine. 14, 12, p. 1880-1891Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a M146I mutation in PSEN1
Li, T., Pires, C., Nielsen, T. T., Waldemar, Gunhild, Hjermind, L. E., Nielsen, Jørgen Erik, Dinnyes, A., Holst, B., Hyttel, P. & Freude, Kristine, Mar 2016, In: Stem Cell Research. 16, 2, p. 334-337 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying an A79V mutation in PSEN1
Li, T., Pires, C., Nielsen, T. T., Waldemar, Gunhild, Hjermind, L. E., Nielsen, Jørgen Erik, Dinnyes, A., Hyttel, P. & Freude, Kristine, Mar 2016, In: Stem Cell Research. 16, 2, p. 229-332 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of SSEA-1 expressing enhanced reprogramming (SEER) cells in porcine embryonic fibroblasts
Li, D., Secher, Jan Bojsen-Møller, Juhl, M., Mashayekhi-Nezamabadi, K., Nielsen, T. T., Holst, B., Hyttel, P., Freude, Kristine & Hall, Vanessa Jane, 2017, In: Cell Cycle. 16, 11, p. 1070-1084Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of transgene-free porcine intermediate type induced pluripotent stem cells
Li, D., Secher, Jan Bojsen-Møller, Hyttel, P., Ivask, M., Kolko, Miriam, Hall, Vanessa Jane & Freude, Kristine, 2018, In: Cell Cycle. 17, 23, p. 2547-2563 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Modelling the neuropathology of lysosomal storage disorders through disease-specific human induced pluripotent stem cells
Kobolák, J., Molnár, K., Varga, E., Bock, I., Jezsó, B., Téglási, A., Zhou, S., Lo Giudice, M., Hoogeveen-Westerveld, M., Pijnappel, W. P., Phanthong, P., Varga, N., Kitiyanant, N., Freude, Kristine, Nakanishi, H., László, L., Hyttel, P. & Dinnyés, A., 2019, In: Experimental Cell Research. 380, 2, p. 216-233 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of two patient specific GABRD variants and their isogenic controls for modeling epilepsy
Kamand, M., Taleb, R., Wathikthinnakon, Methi, Mohamed, Fadumo Abdullahi, Ghanzanfari, S. P., Konstantinov, D., Hald, Jonas Laugård, Holst, B., Andersen, C. B., Møller, R. S., Lemke, J. R., Krey, I., Freude, Kristine & Chandrasekaran, Abinaya, 1 Apr 2024, In: Stem Cell Research. 76Research output: Contribution to journal › Journal article › Research › peer-review
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Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation
Kalscheuer, V. M., Freude, K., Musante, L., Jensen, L. R., Yntema, H. G., Gécz, J., Sefiani, A., Hoffmann, K., Moser, B., Haas, S., Gurok, U., Haesler, S., Aranda, B., Nshedjan, A., Tzschach, A., Hartmann, N., Roloff, T-C., Shoichet, S., Hagens, O., Tao, J. & 14 others, , Dec 2003, In: Nature Genetics. 35, 4, p. 313-5 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Complexity of Sex Differences and Their Impact on Alzheimer’s Disease
Kadlecová, Marion, Freude, Kristine & Haukedal, H., 24 Apr 2023, In: Biomedicines. 11, 5, 29 p., 1261.Research output: Contribution to journal › Review › Research › peer-review
X-linked mental retardation: a comprehensive molecular screen of 47 candidate genes from a 7.4 Mb interval in Xp11
Jensen, L. R., Lenzner, S., Moser, B., Freude, Kristine, Tzschach, A., Wei, C., Fryns, J., Chelly, J., Turner, G., Moraine, C., Hamel, B., Ropers, H. & Kuss, A. W., 2007, In: European Journal of Human Genetics. 15, 1, p. 68-75 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oocytes, embryos and pluripotent stem cells from a biomedical perspective
Hyttel, P., Pessôa, L. V. D. F., Secher, Jan Bojsen-Møller, Dittlau, Katarina Stoklund, Freude, Kristine, Hall, Vanessa Jane, Fair, T., Assey, R. J., Laurincik, J., Callesen, H., Greve, T. & Stroebech, L. B., 2019, In: Animal Reproduction. 16, 3, p. 508-523 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generic benzalkonium chloride‐preserved travoprost eye drops are not identical to the branded polyquarternium‐1‐preserved travoprost eye drop: Effect on cultured human conjunctival goblet cells and their physicochemical properties
Nagstrup, Anne Hedengran, Freiberg, Josefine, Hansen, Pernille May, Jacobsen, Jette, Larsen, Susan Weng, Rønholt, Stine, Freude, Kristine, Boix‐lemonche, G., Petrovski, G., Heegaard, Steffen & Kolko, Miriam, 2022, In: Acta Ophthalmologica. 100, 7, p. 819-827Research output: Contribution to journal › Journal article › Research › peer-review
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Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Haukedal, H. & Freude, Kristine, 2019, In: Journal of Molecular Biology. 431, 9, p. 1818-1829Research output: Contribution to journal › Review › Research › peer-review
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Golgi fragmentation: One of the earliest organelle phenotypes in Alzheimer's disease neurons
Haukedal, H., Corsi, G. I., Gadekar, V. P., Doncheva, N. T., Kedia, S., de Haan, N., Chandrasekaran, A., Jensen, P., Schiønning, P., Vallin, S., Marlet, F. R., Poon, A., Pires, C., Agha, F. K., Wandall, H. H., Cirera, S., Simonsen, A. H., Nielsen, T. T., Nielsen, J. E., Hyttel, P. & 7 others, , 2023, In: Frontiers in Neuroscience. 17, 17 p., 1120086.Research output: Contribution to journal › Journal article › Research › peer-review
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Patient iPSC-Derived Neorons for Disease Modeling of Familiar Alzheimer's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, Oct 2020.Research output: Contribution to conference › Conference abstract for conference › Research
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Inflammatory Responses and Sex Differences of Patient Derived Cell Models of Microglia in Alzheimer's Disease
Haukedal, H., Thomassen, F., Kadlecová, Marion & Freude, Kristine, 20 May 2024.Research output: Contribution to conference › Poster › Communication
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Patient iPSC-Derived Neurons for Disease Modeling of Familiar Alzheier's Disease with Mutations in Presenilin 1
Haukedal, H., Poon, A. F., Jensen, P., Aldana, Blanca, Pires, C., Chandrasekaran, Abinaya, Christensen, S. K., Schiønning, P., Vallin, S., Simonsen, A. H., Nielsen, J., Dinnyes, A., Gorodkin, Jan, Ramakrishna, S., Muddashetty, R., Palakodeti, D., Hyttel, P., Waagepetersen, Helle S., Larsen, M. R. & Freude, Kristine, 26 Mar 2019.Research output: Contribution to conference › Poster › Communication
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Implications of Glycosylation in Alzheimer’s Disease
Haukedal, H. & Freude, Kristine, 2021, In: Frontiers in Neuroscience. 14, 18 p., 625348.Research output: Contribution to journal › Journal article › Research › peer-review
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Alteration of microglial metabolism and inflammatory profile contributes to neurotoxicity in a hiPSC-derived microglia model of frontotemporal dementia 3
Haukedal, H., Syshøj Lorenzen, S., Westi, Emil Winther, Corsi, G., Gadekar, V. P., McQuade, A., Davtyan, H., Doncheva, Nadezhda Tsankova, Schmid, B., Chandrasekaran, Abinaya, Seemann, Ernst Stefan, Cirera, Susanna, Blurton-Jones, M., Meyer, M., Gorodkin, Jan, Aldana, Blanca & Freude, Kristine, 2023, In: Brain, Behavior, and Immunity. 113, p. 353-373Research output: Contribution to journal › Journal article › Research › peer-review
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iPSC-derived Microglia for Disease Modeling of Frontotemporal Dementia 3
Haukedal, H., Freude, Kristine, Garcia, B. A., Corsi, G., Gadekar, V. & Gorodkin, Jan, 2021, In: Glia. 69, S1, p. E480-E481 T14-066D.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets
Garcia Bermudez, Mariana Yolotzin, Freude, Kristine, Mouhammad, Zaynab Ahmad, van Wijngaarden, P., Martin, K. K. & Kolko, Miriam, 2021, In: Frontiers in Neurology. 12, 17 p., 624983.Research output: Contribution to journal › Review › Research › peer-review
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Potential Retinal Biomarkers in Alzheimer's Disease
Garcia Bermudez, Mariana Yolotzin, Vohra, Rupali, Freude, Kristine, van Wijngaarden, P., Martin, K. K., Thomsen, M. S., Aldana, Blanca & Kolko, Miriam, 2023, In: International Journal of Molecular Sciences (Online). 24, 21, 26 p., 15834.Research output: Contribution to journal › Review › Research › peer-review
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Metabolic impairments in neurons and astrocytes derived from human induced pluripotent stem cells of Alzheimer's disease patients
Garcia, B. A., Salcedo, C., Hyttel, P., Waagepetersen, Helle S. & Freude, Kristine, 2019, p. 111-111.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
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Enrichment of retinal ganglion and Müller glia progenitors from retinal organoids derived from human induced pluripotent stem cells - possibilities and current limitations
Freude, Kristine, Saruhanian, S., Mccauley, A., Paterson, C., Odette, M., Oostenink, A., Hyttel, P., Gillies, M., Haukedal, H. & Kolko, Miriam, 2020, In: World Journal of Stem Cells. 12, 10, p. 1171-1183Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial: Metabolic Alterations in Neurodegenerative Disorders
Freude, Kristine, Moreno-gonzalez, I., Rodriguez-ortiz, C. J. & Baglietto-vargas, D., 2022, In: Frontiers in Aging Neuroscience. 14, 3 p., 833109.Research output: Contribution to journal › Editorial › Research › peer-review
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Dementia, Brain Disorders and Molecular Mechanisms
Freude, Kristine & Krauss, S., 2019, In: Journal of Molecular Biology. 431, 9, p. 1709-1710Research output: Contribution to journal › Editorial › Research
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APOE4 IS INSTRUMENTAL IN AUGMENTING RHOA KINASE PHOSPHORYLATION AND CONTRIBUTES THEREBY TO CLASSICAL ALZHEIMER’S DISEASE NEURON PHENOTYPES
Freude, Kristine, Dittlau, Katarina Stoklund & Tao, Ruixin, 5 Mar 2024.Research output: Contribution to conference › Conference abstract for conference › Communication
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Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation
Freude, K., Hoffmann, K., Jensen, L., Delatycki, M. B., des Portes, V., Moser, B., Hamel, B., van Bokhoven, H., Moraine, C., Fryns, J., Chelly, J., Gécz, J., Lenzner, S., Kalscheuer, V. M., Ropers, H. & Freude, Kristine, Aug 2004, In: American Journal of Human Genetics. 75, 2, p. 305-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Induced pluripotent stem cells derived from Alzheimer's disease patients: the promise, the hope and the path ahead
Freude, Kristine, Pires, C., Hyttel, P. & Hall, Vanessa Jane, 2014, In: Journal of Clinical Medicine. 3, 4, p. 1402-1436 35 p.Research output: Contribution to journal › Review › Research › peer-review
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Deciphering the naïve state of porcine iPSC
Freude, Kristine, Secher, Jan Bojsen-Møller, Mashayekhi-Nezamabadi, K., Petkov, S. G., Nielsen, T. T., Ceylan, A., Poligari, S., Dinnyes, A. & Hyttel, P., 18 Jun 2014. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells
Freude, Kristine, Penjwini, M., Davis, J. L., LaFerla, F. M. & Blurton-Jones, M., 2011, In: The Journal of Biological Chemistry. 286, 27, p. 24264-24274 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene.
Frederiksen, Henriette Reventlow S, Holst, B., Mau-Holzmann, U. A., Freude, Kristine & Schmid, B., Mar 2019, In: Stem Cell Research. 35, 4 p., 101403.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel traceable CRISPR-Cas9 engineered human embryonic stem cell line (E1C3 + hSEAP + 2xKO + pCD47), has potential to evade immune detection in pigs
Frederiksen, Henriette Reventlow S, Skov, Søren, Tveden-Nyborg, Pernille, Freude, Kristine & Doehn, U., 7 May 2024, In: Stem Cell Research.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders
Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.Research output: Contribution to journal › Review › Research › peer-review
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Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene
Frederiksen, Henriette Reventlow S, Holst, B., Ramakrishna, S., Muddashetty, R., Schmid, B. & Freude, Kristine, 1 Jan 2019, In: Stem Cell Research. 34, 5 p., 101368.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell type specific expression of toll-like receptors in human brains and implications in Alzheimer's disease
Frederiksen, Henriette Reventlow S, Haukedal, H. & Freude, Kristine, 2019, In: BioMed Research International. 2019, 18 p., 7420189.Research output: Contribution to journal › Review › Research › peer-review
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3D-organization and spatial localization of chromatin and epigenetic marks in relation to nucleolar activity in porcine oocytes
Fenner, Merle Friederike, Benc, M., Rosenbaum Bartkova , A., Pihl, M., Chebrout, M., Freude, Kristine, Strejeck, F., Hyttel, P., Lucas-Hahn, A., Laurincik, J. & Bonnet-Garnier, A., 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Challenges in Establishing Animal Induced Pluripotent Stem Cells
Enevoldsen, Sara, Magnusson, H. B. D., Lind, J. U., Freude, Kristine & Callø, Kirstine, 15 Sep 2023.Research output: Contribution to conference › Poster › Communication
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Generation of three isogenic gene-edited Huntington’s disease human embryonic stem cell lines with DOX-inducible NGN2 expression cassette in the AAVS1 safe locus
Duque Villegas, Luisana Carolina, Chandrasekaran, Abinaya, Flintholm Andersen, S. A., Nørremølle, Anne, Schmid, B., Pouladi, M. A. & Freude, Kristine, 2024, In: Stem Cell Research. 77, 6 p., 103408.Research output: Contribution to journal › Journal article › Research › peer-review
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Astrocytes: The Stars in Neurodegeneration?
Dittlau, Katarina Stoklund & Freude, Kristine, 28 Feb 2024, In: Biomolecules.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies
Dittlau, Katarina Stoklund, Chandrasekaran, Abinaya, Freude, Kristine & Van Den Bosch, L., 2024, In: Bio-protocol. 14, 4, 16 p., e4936.Research output: Contribution to journal › Journal article › Research › peer-review
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Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
De Figueiredo Pessôa, L. V., Chandrasekaran, Abinaya, Thomsen, B. B., Berendt, Mette, Hyttel, P. & Freude, Kristine, 2020, iPSCs from Diverse Species. Academic Press, p. 77-91 15 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression
Corsi, G. I., Gadekar, V. P., Haukedal, H., Doncheva, Nadezhda Tsankova, Anthon, Christian, Ambardar, S., Palakodeti, D., Hyttel, P., Freude, Kristine, Seemann, Ernst Stefan & Gorodkin, Jan, 2023, In: Neurobiology of Disease. 178, 17 p., 105980.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 38189431
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Induced pluripotent stem cells derived from Alzheimer's disease patients: the promise, the hope and the path ahead
Research output: Contribution to journal › Review › Research › peer-review
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
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330
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Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM)
Research output: Contribution to journal › Journal article › Research › peer-review
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