Kristine Freude
Professor
Pathobiological Sciences
Grønnegårdsvej 7, 1870 Frederiksberg C
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Characterization of energy and neurotransmitter metabolism in cortical glutamatergic neurons derived from human induced pluripotent stem cells: A novel approach to study metabolism in human neurons
Aldana, Blanca, Zhang, Y., Lihme, M. F., Bak, Lasse Kristoffer, Nielsen, Jørgen Erik, Holst, B., Hyttel, P., Freude, Kristine & Waagepetersen, Helle S., 2017, In: Neurochemistry International. 106, p. 48-61Research output: Contribution to journal › Journal article › Research › peer-review
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Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia
Aldana, Blanca, Zhang, Y., Jensen, P., Chandrasekaran, Abinaya, Christensen, S. K., Nielsen, T. T., Nielsen, Jørgen Erik, Hyttel, P., Larsen, M. R., Waagepetersen, Helle S. & Freude, Kristine, 2020, In: Molecular Brain. 13, 1, 7 p., 125.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellular bioenergetics in human iPSC-derived glutamatergic neurons in health and disease
Aldana, Blanca, Salcedo, C., Freude, Kristine & Waagepetersen, Helle S., 2021, Current Progress in iPSC-derived Cell Types. Birbrair, A. (ed.). Elsevier, p. 205-221 17 p. (Advances in Stem Cell Biology, Vol. 10).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer’s Disease
Ameen, Aisha, Freude, Kristine & Aldana, Blanca, 2022, In: Biomedicines. 10, 11, 2778.Research output: Contribution to journal › Journal article › Research › peer-review
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Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease
Andersen, Jens Velde, Skotte, Niels Henning, Christensen, S. K., Polli, F. S., Shabani, M., Markussen, K. H., Haukedal, H., Westi, Emil Winther, Diaz-delCastillo, M., Sun, R. C., Kohlmeier, Kristi Anne, Schousboe, Arne, Gentry, M. S., Tanila, H., Freude, Kristine, Aldana, Blanca, Mann, Matthias & Waagepetersen, Helle S., 2021, In: Cell Death & Disease. 12, 11, 13 p., 954 .Research output: Contribution to journal › Journal article › Research › peer-review
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Fordele og ulemper ved anvendelse af autologe versus allogene stamceller til behandling af artrose
Bagge, J., Freude, Kristine, Lindegaard, Casper, Holst, B. & Hölmich, Per, 2024, In: Ugeskrift for Laeger. 186, 7 p., V06230423.Research output: Contribution to journal › Journal article › Communication
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Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state
Bernardo, A. S., Jouneau, A., Marks, H., Kensche, P., Kobolak, J., Freude, K., Hall, V., Feher, A., Polgar, Z., Sartori, C., Bock, I., Louet, C., Faial, T., Kerstens, H. H. D., Bouissou, C., Parsonage, G., Mashayekhi, K., Smith, J. C., Lazzari, G., Hyttel, P. & 4 others, , 2018, In: Biology Open. 7, 8, 17 p., bio033282.Research output: Contribution to journal › Journal article › Research › peer-review
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Chromatin organization, spatial localization of heterochromatin sequences and nucleolar activity, change towards final maturation in porcine oocytes
Bonnet-Garnier, A., Benc, M., Bartkova, A., Pihl, M., Chebrout, M., Strejcek, F., Hyttel, P., Lucas-Hahn, A., Laurincik, J., Freude, Kristine & Fenner, Merle Friederike, 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Neuronal alpha-amylase is important for neuronal activity and glycogenolysis and reduces in presence of amyloid beta pathology
Byman, E., Martinsson, I., Haukedal, H., Gouras, G., Freude, Kristine, Wennstrom, M. & Netherlands Brain Ban, N. B. B., 2021, In: Aging Cell. 20, 8, 14 p., 13433.Research output: Contribution to journal › Journal article › Research › peer-review
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The G213D variant in Nav1.5 alters sodium current and causes an arrhythmogenic phenotype resulting in a multifocal ectopic Purkinje-related premature contraction phenotype in human-induced pluripotent stem cell-derived cardiomyocytes
Callø, Kirstine, Geryk, M., Freude, Kristine, Treat, J. A., Vold, V. A., Frederiksen, Henriette Reventlow S, Broendberg, A. K., Frederiksen, T. C., Jensen, H. K. & Cordeiro, J. M., 2022, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 24, 12, p. 2015–2027Research output: Contribution to journal › Journal article › Research › peer-review
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A protein-centric view of in vitro biological model systems for schizophrenia
Chandrasekaran, Abinaya, Jensen, P., Mohamed, Fadumo Abdullahi, Lancaster, M., Benros, Michael Eriksen, Larsen, M. R. & Freude, Kristine, 2021, In: Stem Cells. 39, 12, p. 1569-1578Research output: Contribution to journal › Review › Research › peer-review
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Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3
Chandrasekaran, A., Dittlau, K. S., Corsi, G. I., Haukedal, H., Doncheva, N. T., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Zhang, Y., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J. E., Kolko, M., Kobolák, J., Dinnyés, A., Hyttel, P., Palakodeti, D. & 5 others, , 2021, In: Stem Cell Reports. 16, 11, p. 2736-2751Research output: Contribution to journal › Journal article › Research › peer-review
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Mutations in FTD3 CHMP2B causes impaired autophagy and distorted energy metabolism cumulating in reactive astrocyte phenotypes
Chandrasekaran, A., Dittlau, K. S., Corsi, G., Doncheva, N. T., Haukedal, H., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J., Kolko, M., Kobolak, J., Dinnyes, A., Hyttel, P., Palakodeti, D., Gorodkin, J. & 4 others, , 2020.Research output: Contribution to conference › Poster › Research
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Mutation in FTD3 CHMP2B causes impaired autography and distorted energy metabolism cumulating in reactive astrocyte phenotypes
Chandrasekaran, A., Dittlau, K. S., Corsi, G., Haukedal, H., Doncheva, N. T., Ramakrishna, S., Ambardar, S., Salcedo, C., Schmidt, S. I., Cirera, S., Pihl, M., Schmid, B., Nielsen, T. T., Nielsen, J., Kolko, M., Kobolak, J., Dinnyes, A., Hyttel, P., Palakodeti, D., Gorodkin, J. & 4 others, , 2020.Research output: Contribution to conference › Conference abstract for conference › Research
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Neural Derivates of Canine Induced Pluripotent Stem Cells-Like Cells From a Mild Cognitive Impairment Dog
Chandrasekaran, Abinaya, Thomsen, B. B., Agerholm, Jørgen Steen, Pessôa, L. V. D. F., Godoy Pieri, N. C., Sabaghidarmiyan, V., Langley, K., Kolko, Miriam, De Andrade, A. F. C., Bressan, F. F., Hyttel, P., Berendt, Mette & Freude, Kristine, 2021, In: Frontiers in Veterinary Science. 8, 14 p., 725386.Research output: Contribution to journal › Journal article › Research › peer-review
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The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression
Corsi, G. I., Gadekar, V. P., Haukedal, H., Doncheva, Nadezhda Tsankova, Anthon, Christian, Ambardar, S., Palakodeti, D., Hyttel, P., Freude, Kristine, Seemann, Ernst Stefan & Gorodkin, Jan, 2023, In: Neurobiology of Disease. 178, 17 p., 105980.Research output: Contribution to journal › Journal article › Research › peer-review
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Canine induced pluripotent stem cells: An in vitro approach to validate the dog as a large animal model for Alzheimer’s disease
De Figueiredo Pessôa, L. V., Chandrasekaran, Abinaya, Thomsen, B. B., Berendt, Mette, Hyttel, P. & Freude, Kristine, 2020, iPSCs from Diverse Species. Academic Press, p. 77-91 15 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Astrocytes: The Stars in Neurodegeneration?
Dittlau, Katarina Stoklund & Freude, Kristine, 28 Feb 2024, In: Biomolecules.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies
Dittlau, Katarina Stoklund, Chandrasekaran, Abinaya, Freude, Kristine & Van Den Bosch, L., 2024, In: Bio-protocol. 14, 4, 16 p., e4936.Research output: Contribution to journal › Journal article › Research › peer-review
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Generation of three isogenic gene-edited Huntington’s disease human embryonic stem cell lines with DOX-inducible NGN2 expression cassette in the AAVS1 safe locus
Duque Villegas, Luisana Carolina, Chandrasekaran, Abinaya, Flintholm Andersen, S. A., Nørremølle, Anne, Schmid, B., Pouladi, M. A. & Freude, Kristine, 2024, In: Stem Cell Research. 77, 6 p., 103408.Research output: Contribution to journal › Journal article › Research › peer-review
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Challenges in Establishing Animal Induced Pluripotent Stem Cells
Enevoldsen, Sara, Magnusson, H. B. D., Lind, J. U., Freude, Kristine & Callø, Kirstine, 15 Sep 2023.Research output: Contribution to conference › Poster › Communication
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3D-organization and spatial localization of chromatin and epigenetic marks in relation to nucleolar activity in porcine oocytes
Fenner, Merle Friederike, Benc, M., Rosenbaum Bartkova , A., Pihl, M., Chebrout, M., Freude, Kristine, Strejeck, F., Hyttel, P., Lucas-Hahn, A., Laurincik, J. & Bonnet-Garnier, A., 2023. 1 p.Research output: Contribution to conference › Poster › Research › peer-review
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Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene
Frederiksen, Henriette Reventlow S, Holst, B., Ramakrishna, S., Muddashetty, R., Schmid, B. & Freude, Kristine, 1 Jan 2019, In: Stem Cell Research. 34, 5 p., 101368.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell type specific expression of toll-like receptors in human brains and implications in Alzheimer's disease
Frederiksen, Henriette Reventlow S, Haukedal, H. & Freude, Kristine, 2019, In: BioMed Research International. 2019, 18 p., 7420189.Research output: Contribution to journal › Review › Research › peer-review
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Non-immunogenic Induced Pluripotent Stem Cells, a Promising Way Forward for Allogenic Transplantations for Neurological Disorders
Frederiksen, Henriette Reventlow S, Doehn, U., Tveden-Nyborg, Pernille & Freude, Kristine, 2021, In: Frontiers in Genome Editing. 2, 623717.Research output: Contribution to journal › Review › Research › peer-review
ID: 38189431
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809
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Induced pluripotent stem cells derived from Alzheimer's disease patients: the promise, the hope and the path ahead
Research output: Contribution to journal › Review › Research › peer-review
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461
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Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
328
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Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM)
Research output: Contribution to journal › Journal article › Research › peer-review
Published