Kristine Freude

Kristine Freude

Professor


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  1. Published

    The positional identity of iPSC-derived neural progenitor cells along the anterior-posterior axis is controlled in a dosage-dependent manner by bFGF and EGF

    Zhou, S., Ochalek, A., Szczesna, K., Avci, H. X., Kobolak, J., Varga, E., Rasmussen, M., Holst, B., Cirera, Susanna, Hyttel, P., Freude, Kristine & Dinnyes, A., Oct 2016, In: Differentiation. 92, 4, p. 183-194 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Neurosphere based differentiation of human iPSC improves astrocyte differentiation

    Zhou, S., Szczesna, K., Ochalek, A., Kobolák, J., Varga, E., Nemes, C., Chandrasekaran, A., Rasmussen, M., Cirera, Susanna, Hyttel, P., Dinnyés, A., Freude, Kristine & Avci, H. X., 2016, In: Stem Cells International. 2016, 15 p., 4937689.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific homozygous mutation in CHMP2B

    Zhang, Y., Schmid, B., Nielsen, T. T., Nielsen, Jørgen Erik, Clausen, C., Hyttel, P., Holst, B. & Freude, Kristine, 2016, In: Stem Cell Research. 17, 1, p. 151-153 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Patient iPSC-derived neurons for disease modeling of frontotemporal dementia with mutation in CHMP2B

    Zhang, Y., Schmid, B., Qas Younan, N. K., Rasmussen, M. A., Garcia, B. I. A., Agger, M., Callø, K., Stummann, T. C., Larsen, H. M., Nielsen, T. T., Huang, J., Xu, F., Liu, X., Bolund, L., Meyer, M., Bak, L. K., Waagepetersen, H. S., Luo, Y., Nielsen, J. E., Consortium, T. FRA. & 4 others, Holst, B., Clausen, C., Hyttel, P. & Freude, Kristine, 2017, In: Stem Cell Reports. 8, 3, p. 648-658

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Generation of a human induced pluripotent stem cell line via CRISPR-Cas9 mediated integration of a site-specific heterozygous mutation in CHMP2B

    Zhang, Y., Schmid, B., Nielsen, T. T., Nielsen, Jørgen Erik, Clausen, C., Hyttel, P., Holst, B. & Freude, Kristine, Jul 2016, In: Stem Cell Research. 17, 1, p. 148-150 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Mitochondrial Spare Respiratory Capacity Is Negatively Correlated with Nuclear Reprogramming Efficiency

    Yan, Z., Al-Saaidi, R. A., Fernandez Guerra, P., Freude, Kristine, Olsen, R. K. J., Jensen, U. B., Gregersen, N., Hyttel, P., Bolund, L., Aagaard, L., Bross, P. & Luo, Y., 2017, In: Stem Cells and Development. 26, 3, p. 166-176

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    RNA-Guided Activation of Pluripotency Genes in Human Fibroblasts

    Xiong, K., Zhou, Y., Blichfeld, K. A., Hyttel, P., Bolund, L., Freude, Kristine & Luo, Y., Jun 2017, In: Cellular Reprogramming. 19, 3, p. 189-198 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM)

    Xiong, K., Zhou, Y., Hyttel, P., Bolund, L., Freude, Kristine & Luo, Y., Nov 2016, In: Stem Cell Research. 17, 3, p. 665-669 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Swedish Alzheimer mutation induces mitochondrial dysfunction mediated by HSP60 mislocalization of amyloid precursor protein (APP) and beta-amyloid

    Walls, K. C., Coskun, P., Gallegos-Perez, J. L., Zadourian, N., Freude, Kristine, Rasool, S., Blurton-Jones, M., Green, K. N. & LaFerla, F. M., 2012, In: Journal of Biological Chemistry. 287, 36, p. 30317-30327 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Essential Roles of Lactate in Müller Cell Survival and Function

    Vohra, Rupali, Aldana, Blanca, Jensen, Dorte Skytt, Freude, Kristine, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, 1 Dec 2018, In: Molecular Neurobiology. 55, 12, p. 9108-9121 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Prevention of Cell Death by Activation of Hydroxycarboxylic Acid Receptor 1 (GPR81) in Retinal Explants

    Vohra, Rupali, Sanz-Morello, B., Tams, A. L. M., Mouhammad, Zaynab Ahmad, Freude, Kristine, Hannibal, Jens, Aldana, Blanca, Bergersen, L. H. & Kolko, Miriam, 2022, In: Cells. 11, 13, 2098.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Muller cell survival and function is maintained by the presence of lactate

    Vohra, Rupali, Skytt, D. M., Aldana, Blanca, Freude, Kristine, Waagepetersen, Helle S., Bergersen, L. H. & Kolko, Miriam, Jul 2018, p. 1480. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  13. Published

    Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

    Duque Villegas, Luisana Carolina, Nørremølle, Anne, Freude, Kristine & Vilhardt, Frederik, 2021, In: Frontiers in Aging Neuroscience. 13, 20 p., 736734.

    Research output: Contribution to journal › Review › Research › peer-review

  14. Published

    Generation of induced pluripotent stem cells (iPSCs) from an Alzheimer's disease patient carrying a L150P mutation in PSEN-1

    Tubsuwan, A., Pires, C., Rasmussen, M. A., Schmid, B., Nielsen, Jørgen Erik, Hjermind, L. E., Hall, Vanessa Jane, Nielsen, T. T., Waldemar, Gunhild, Hyttel, P., Clausen, C., Kitiyanant, N., Freude, Kristine & Holst, B., Jan 2016, In: Stem Cell Research. 16, 1, p. 110-112 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer's Disease

    Tams, A. L. M., Sanz-Morello, B., Westi, Emil Winther, Mouhammad, Zaynab Ahmad, Andersen, Jens Velde, Freude, Kristine, Vohra, Rupali, Hannibal, Jens, Aldana, Blanca & Kolko, Miriam, 2022, In: Cellular and Molecular Neurobiology. 42, 1, p. 291–303

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    In vitro production of bovine embryos: revisiting oocyte development and application of systems biology

    Stroebech, L., Mazzoni, G., Pedersen, H. S., Freude, Kristine, Kadarmideen, H., Callesen, H. & Hyttel, P., 1 Aug 2015, In: Animal Reproduction. 12, 3, p. 465-472 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanisms

    Dittlau, Katarina Stoklund, Terrie, L., Baatsen, P., Kerstens, A., De Swert, L., Janky, R., Corthout, N., Masrori, P., Van Damme, P., Hyttel, P., Meyer, M., Thorrez, L., Freude, Kristine & Van Den Bosch, L., 2023, In: Molecular Neurodegeneration. 18, 1, 5.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Role of S1P-receptor and Rho-kinase in myogenic tone in mesenteric and cerebral arteries of young vs. middle-aged mice

    Skovsted, Gry Freja, Aupetit, A., Björling , K., Haanes, K. A., Syberg, S., Jørgensen, N. R., Freude, Kristine, Pearson, J. T. & Jensen, Lars Jørn, 2023, In: Acta Physiologica. 239, S728, e14042.

    Research output: Contribution to journal › Conference abstract in journal › Communication

  19. A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

    Seymour, Philip Allan, Shih, H. P., Patel, N. A., Freude, Kristine, Xie, R., Lim, C. J. & Sander, M., Sep 2012, In: Development. 139, 18, p. 3363-72 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. SOX9 is required for maintenance of the pancreatic progenitor cell pool

    Seymour, Philip Allan, Freude, Kristine, Tran, M. N., Mayes, E. E., Jensen, J., Kist, R., Scherer, G. & Sander, M., 6 Feb 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1865-70 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation

    Seymour, Philip Allan, Freude, Kristine, Dubois, C. L., Shih, H., Patel, N. A. & Sander, M., 1 Nov 2008, In: Advances in Developmental Biology. 323, 1, p. 19-30 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Initial embryology and pluripotent stem cells in the pig: the quest for establishing the pig as a model for cell therapy

    Secher, Jan Bojsen-Møller, Callesen, H., Freude, Kristine & Hyttel, P., 1 Jan 2016, In: Theriogenology. 85, 1, p. 162-171 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Assessment of porcine-induced pluripotent stem cells by in vivo assays

    Secher, Jan Bojsen-Møller, Freude, Kristine, Petkov, S. G., Ceylan, A., Schmidt, M. & Hyttel, P., 1 Dec 2014. 1 p.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  24. Published

    Optimization of three-dimensional imaging on in vitro produced porcine blastocysts and chimeras for stem cell testing: a technology report.

    Secher, Jan Bojsen-Møller, Freude, Kristine, Li, R. & Callesen, H., 2015, In: Stem Cells and Development. 24, 9, p. 1141-1145 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells

    Secher, J. O. B., Ceylan, A., Mazzoni, G., Mashayekhi-Nezamabadi, K., Li, T., Muenthaisong, S., Nielsen, T., Li, D., Li, S., Petkov, S. G., Cirera Salicio, S., Luo, Y., Thombs, L., Kadarmideen, H., Dinnyés, A., Bolund, L., Roelen, B. A., Schmidt, M., Callesen, H., Hyttel, P. & 1 others, Freude, Kristine, 2017, In: Molecular Reproduction and Development. 84, 3, p. 229-245

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Evaluation of porcine stem cell competence for somatic cell nuclear transfer and production of cloned animals

    Secher, Jan Bojsen-Møller, Liu, Y., Petkov, S. G., Li, D., Hall, Vanessa Jane, Schmidt, M., Callesen, H., Freude, Kristine & Hyttel, P., 2017, In: Animal Reproduction Science. 178, p. 40-49

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    RhoA Signaling in Neurodegenerative Diseases

    Schmidt, S. I., Blaabjerg, M., Freude, Kristine & Meyer, M., 2022, In: Cells. 11, 9, 1520.

    Research output: Contribution to journal › Review › Research › peer-review

  28. Published

    Microglia-Secreted Factors Enhance Dopaminergic Differentiation of Tissue- and iPSC-Derived Human Neural Stem Cells

    Schmidt, S. I., Bogetofte, H., Ritter, L., Agergaard, Jette Bach, Hammerich, D., Kabiljagic, A. A., Wlodarczyk, A., Lopez, S. G., Sørensen, M. D., Jørgensen, M. L., Okarmus, J., Serrano, A. M., Kristensen, Bjarne Winther, Freude, Kristine, Owens, T. & Meyer, M., 2021, In: Stem Cell Reports. 16, p. 1-14

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors

    Schaffer, A. E., Freude, Kristine, Nelson, S. B. & Sander, M., 2010, In: Developmental Cell. 18, 6, p. 1022-1029 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Oxidative stress in optic neuropathies

    Sanz-Morello, B., Ahmadi, H., Vohra, Rupali, Saruhanian, S., Freude, Kristine, Hamann, Steffen & Kolko, Miriam, 2021, In: Antioxidants. 10, 10, 27 p., 1538.

    Research output: Contribution to journal › Review › Research › peer-review

  31. Published

    Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease

    Salcedo, C., Wagner, A., Andersen, Jens Velde, Vinten, K. T., Waagepetersen, Helle S., Schousboe, Arne, Freude, Kristine & Aldana, Blanca, 2021, In: Neurochemical Research. 46, p. 2676–2686

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

    Salcedo, C., Andersen, Jens Velde, Vinten, K. T., Pinborg, Lars Hageman, Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2021, In: Frontiers in Aging Neuroscience. 13, 736580.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. E-pub ahead of print

    Increased glucose metabolism and impaired glutamate transport in human astrocytes are potential early triggers of abnormal extracellular glutamate accumulation in hiPSC-derived models of Alzheimer's disease

    Salcedo, C., Pozo Garcia, V., Garcia-Adan, B., Ameen, Aisha, Gegelashvili, G., Waagepetersen, Helle S., Freude, Kristine & Aldana, Blanca, 2024, (E-pub ahead of print) In: Journal of Neurochemistry.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Generation of eight hiPSCs lines from two pathogenic variants in CACNA1A using the CRISPR-Cas9 gene editing technology

    Rivera-Sánchez, P., Søndergaard, L., Wathikthinnakon, Methi, B. D. Magnusson, H., Frederiksen, Henriette Reventlow S, Aabæk Hammer, F., Taleb, R., Christian Cassidy, C., Tranholm Bruun, M., Tümer, Asuman Zeynep, Holst, B., Brasch-Andersen, C., Møller, R., Freude, Kristine & Chandrasekaran, Abinaya, 2023, In: Stem Cell Research. 71, 103193.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    APOE4 affects basal and NMDAR mediated protein synthesis in neurons by perturbing calcium homeostasis

    Ramakrishna, S., Jhaveri, V., Konings, S. C., Nawalpuri, B., Chakraborty, S., Holst, B., Schmid, B., Gouras, G. K., Freude, Kristine & Muddashetty, R. S., 2021, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 41, 42, p. 8686-8709

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

    Prakash, N., Puelles, E., Freude, Kristine, Trümbach, D., Omodei, D., Di Salvio, M., Sussel, L., Ericson, J., Sander, M., Simeone, A. & Wurst, W., 2009, In: Development (Cambridge, England). 136, 15, p. 2545-2555 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1

    Poon, A. F., Li, T., Pires, C., Nielsen, T. T., Nielsen, Jørgen Erik, Holst, B., Dinnyes, A., Hyttel, P. & Freude, Kristine, Nov 2016, In: Stem Cell Research. 17, 3, p. 470-473 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Generation of a gene-corrected isogenic control hiPSC line derived from a familial Alzheimer's disease patient carrying a L150P mutation in presenilin 1

    Poon, A. F., Schmid, B., Pires, C., Nielsen, T. T., Hjermind, L. E., Nielsen, Jørgen Erik, Holst, B., Hyttel, P. & Freude, Kristine, Nov 2016, In: Stem Cell Research. 17, 3, p. 466-469 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Modeling neurodegenerative diseases with patient-derived induced pluripotent cells: Possibilities and challenges

    Poon, A., Zhang, Y., Chandrasekaran, Abinaya, Phanthong, P., Schmid, B., Nielsen, T. T. & Freude, Kristine, 2017, In: New Biotechnology. 39, Part B, p. 190-198

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    Generation of a gene-corrected isogenic control cell line from an Alzheimer's disease patient iPSC line carrying a A79V mutation in PSEN1

    Pires, C., Schmid, B., Petræus, C., Poon, A. F., Nimsanor, N., Nielsen, T. T., Waldemar, Gunhild, Hjermind, L. E., Nielsen, Jørgen Erik, Hyttel, P. & Freude, Kristine, Sep 2016, In: Stem Cell Research. 17, 2, p. 285-288 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Human Induced Pluripotent stem cells and their derivatives for disease modeling and therapeutic applications in Alzheimer's disease

    Pires, C., Hall, Vanessa Jane & Freude, Kristine, 20 May 2016, Alzheimer's disease. SMGroup, p. 1-25 25 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  42. Published

    Toward Development of Pluripotent Porcine Stem Cells by Road Mapping Early Embryonic Development

    Petkov, S., Freude, Kristine, Mashayekhi-Nezamabadi, K., Hyttel, P. & Hall, Vanessa Jane, Mar 2017, Animal Models and Human Reproduction: Cell and Molecular Approaches with Reference to Human Reproduction. Schatten, H. & Constantinescu, G. M. (eds.). Wiley-Blackwell, p. 485-508 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  43. Published

    Induced pluripotent stem cells throughout the animal kingdom: Availability and applications

    Pessôa, L. V. D. F., Bressan, F. F. & Freude, Kristine, 2019, In: World Journal of Stem Cells. 11, 8, p. 491-505 15 p.

    Research output: Contribution to journal › Review › Research › peer-review

  44. Published

    Canine induced pluripotent stem cells: an in vitro approach to validate the dog as a large animal model for Alzheimer's disease

    Pessoa, L. V. D. F., Chandrasekaran, Abinaya, Thomsen, B. B., Berendt, Mette, Hyttel, P. & Freude, Kristine, Sep 2020, iPSCs from Diverse Species. 1 ed. Elsevier: Academic Press, Vol. 2.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  45. Published

    WebCircRNA: Classifying the Circular RNA Potential of Coding and Noncoding RNA.

    Pan, X., Xiong, K., Anthon, Christian, Hyttel, P., Freude, Kristine, Jensen, Lars Juhl & Gorodkin, Jan, 6 Nov 2018, In: Genes. 9, 11, 11 p., 536.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    USP30 inhibition induces mitophagy and reduces oxidative stress in parkin-deficient human neurons

    Okarmus, J., Agergaard, J. B., Stummann, T., Haukedal, H., Ambjørn, M., Freude, Kristine, Fog, K. & Meyer, M., 14 Jan 2024, In: Nature.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

    Ochalek, A., Mihalik, B., Avci, H. X., Chandrasekaran, Abinaya, Téglási, A., Bock, I., Giudice, M. L., Táncos, Z., Molnár, K., László, L., Nielsen, Jørgen Erik, Holst, B., Freude, Kristine, Hyttel, P., Kobolák, J. & Dinnyés, A., Dec 2017, In: Alzheimer's Research and Therapy. 9, 1, 19 p., 90.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Human induced pluripotent cells in personalized treatment of monogenic epilepsies

    Mohammad, N. A., Freude, Kristine, Haukedal, H., Tümer, Asuman Zeynep & Møller, R. S., 2020, In: Journal of Translational Genetics and Genomics. 2020, 4, p. 238-250

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Implications of SNP-triggered miRNA dysregulation in Schizophrenia development

    Mohamed, Fadumo Abdullahi & Freude, Kristine, 26 Jan 2024, In: Frontiers in Genetics.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Genetic protection modifications: Moving beyond the binary distinction between therapy and enhancement for human genome editing

    Mikkelsen, R. C. B., Frederiksen, Henriette Reventlow S, Gjerris, Mickey, Holst, B., Hyttel, P., Luo, Y., Freude, Kristine & Sandøe, Peter, 2019, In: CRISPR Journal. 2, 6, p. 362-369 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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